Reconstituting the Mammalian Apoptotic Switch in Yeast

Adams, 2007, The Bcl-2 apoptotic switch in cancer development and therapy, Oncogene, 26, 1324, 10.1038/sj.onc.1210220

Green, 2016, Just So Stories about the Evolution of Apoptosis, Curr. Biol., 26, R620, 10.1016/j.cub.2016.05.023

Gupta, 2009, The mitochondrial death pathway: A promising therapeutic target in diseases, J. Cell Mol. Med., 13, 1004, 10.1111/j.1582-4934.2009.00697.x

Bratton, 2010, Regulation of the Apaf-1-caspase-9 apoptosome, J. Cell Sci., 123, 3209, 10.1242/jcs.073643

Hawkins, 2001, Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism, Apoptosis, 6, 331, 10.1023/A:1011329917895

Kvansakul, 2014, The Structural Biology of BH3-Only Proteins, Regul. Cell Death Pt A: Apoptotic Mech., 544, 49

Bakhshi, 1985, Cloning the Chromosomal Breakpoint of T(14-18) Human Lymphomas—Clustering around Jh on Chromosome-14 and near a Transcriptional Unit on 18, Cell, 41, 899, 10.1016/S0092-8674(85)80070-2

Cleary, 1985, Nucleotide-Sequence of a T(14,18) Chromosomal Breakpoint in Follicular Lymphoma and Demonstration of a Breakpoint-Cluster Region near a Transcriptionally Active Locus on Chromosome-18, Proc. Natl. Acad. Sci. USA, 82, 7439, 10.1073/pnas.82.21.7439

Tsujimoto, 1985, Involvement of the Bcl-2 Gene in Human Follicular Lymphoma, Science, 228, 1440, 10.1126/science.3874430

Youle, 2008, The BCL-2 protein family: Opposing activities that mediate cell death, Nat. Rev. Mol. Cell Biol., 9, 47, 10.1038/nrm2308

Aouacheria, 2012, Evolution of Bcl-2 homology motifs: Homology versus homoplasy, Trends Cell. Biol., 23, 103, 10.1016/j.tcb.2012.10.010

Oltvai, 1993, Bcl-2 Heterodimerizes in-Vivo with a Conserved Homolog, Bax, That Accelerates Programmed Cell-Death, Cell, 74, 609, 10.1016/0092-8674(93)90509-O

Chittenden, 1995, Induction of Apoptosis by the Bcl-2 Homolog Bak, Nature, 374, 733, 10.1038/374733a0

Hsu, 1997, Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members, Proc. Natl. Acad. Sci. USA, 94, 12401, 10.1073/pnas.94.23.12401

Hsu, 1997, Cytosol-to-membrane redistribution of Bax and Bcl-X-L during apoptosis, Proc. Natl. Acad. Sci. USA, 94, 3668, 10.1073/pnas.94.8.3668

Wolter, 1997, Movement of Bax from the cytosol to mitochondria during apoptosis, J. Cell Biol., 139, 1281, 10.1083/jcb.139.5.1281

Llambi, 2016, BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation, Cell, 165, 421, 10.1016/j.cell.2016.02.026

Kaufmann, 2003, Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane, J. Cell Biol., 160, 53, 10.1083/jcb.200210084

Shibue, 2006, BH3-only proteins: Integrated control point of apoptosis, Int. J. Cancer, 119, 2036, 10.1002/ijc.21751

Happo, 2012, BH3-only proteins in apoptosis at a glance, J. Cell Sci., 125, 1081, 10.1242/jcs.090514

Suzuki, 2000, Structure of Bax: coregulation of dimer formation and intracellular localization, Cell, 103, 645, 10.1016/S0092-8674(00)00167-7

Muchmore, 1996, X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death, Nature, 381, 335, 10.1038/381335a0

Petros, 2004, Structural biology of the Bcl-2 family of proteins, Biochim. Biophys. Acta, 1644, 83, 10.1016/j.bbamcr.2003.08.012

Rautureau, 2010, Intrinsically disordered proteins in bcl-2 regulated apoptosis, Int. J. Mol. Sci., 11, 1808, 10.3390/ijms11041808

Eisenberg, 2010, Apoptosis in yeast: Triggers, pathways, subroutines, Cell Death Differ., 17, 763, 10.1038/cdd.2009.219

Bauer, 2018, Guidelines and recommendations on yeast cell death nomenclature, Microb. Cell, 5, 4, 10.15698/mic2018.01.607

Sato, 1994, Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system, Proc. Natl. Acad. Sci. USA, 91, 9238, 10.1073/pnas.91.20.9238

Zha, 1996, Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells, Mol. Cell Biol., 16, 6494, 10.1128/MCB.16.11.6494

Manon, 1997, Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL, FEBS Lett., 415, 29, 10.1016/S0014-5793(97)01087-9

Pavlov, 2001, A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast, J. Cell Biol., 155, 725, 10.1083/jcb.200107057

Danial, 2004, Cell death: Critical control points, Cell, 116, 205, 10.1016/S0092-8674(04)00046-7

Priault, 1999, Comparison of the effects of bax-expression in yeast under fermentative and respiratory conditions: Investigation of the role of adenine nucleotides carrier and cytochrome c, FEBS Lett., 456, 232, 10.1016/S0014-5793(99)00957-6

Gross, 2000, Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L), Mol. Cell Biol., 20, 3125, 10.1128/MCB.20.9.3125-3136.2000

Zeman, 2000, The cytotoxic action of Bax on yeast cells does not require mitochondrial ADP/ATP carrier but may be related to its import to the mitochondria, FEBS Lett., 471, 113, 10.1016/S0014-5793(00)01379-X

Pfanner, 1998, Mitochondrial import: Crossing the aqueous intermembrane space, Curr. Biol., 8, R262, 10.1016/S0960-9822(98)70168-X

Vogtle, 2007, Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins, J. Mol. Biol., 368, 44, 10.1016/j.jmb.2007.01.016

Ligr, 1998, Mammalian Bax triggers apoptotic changes in yeast, FEBS Lett., 438, 61, 10.1016/S0014-5793(98)01227-7

Mentel, 2015, Yeast as a tool for studying proteins of the Bcl-2 family, Microb. Cell, 2, 74, 10.15698/mic2015.03.193

Legiot, 2019, Mitochondria-Associated Membranes (MAMs) are involved in Bax mitochondria! localization and cytochrome c release, Microb. Cell, 6, 257, 10.15698/mic2019.05.678

Simmen, 2017, Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs), Organelle Contact Sites: From Molecular Mechanism to Disease, Volume 997, 13, 10.1007/978-981-10-4567-7_2

Willis, 2005, Life in the balance: How BH3-only proteins induce apoptosis, Curr. Opin. Cell Biol., 17, 617, 10.1016/j.ceb.2005.10.001

Renault, 2011, Bax: Addressed to kill, Biochimie, 93, 1379, 10.1016/j.biochi.2011.05.013

Greenhalf, 1996, Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae, FEBS Lett., 380, 169, 10.1016/0014-5793(96)00044-0

Tao, 1997, Modulation of cell death in yeast by the Bcl-2 family of proteins, J. Biol. Chem., 272, 15547, 10.1074/jbc.272.24.15547

Matsuyama, 1998, The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells, Mol. Cell, 1, 327, 10.1016/S1097-2765(00)80033-7

Xu, 1998, Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast, Mol. Cell, 1, 337, 10.1016/S1097-2765(00)80034-9

Marzo, 1998, Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis, Science, 281, 2027, 10.1126/science.281.5385.2027

Huang, 2016, Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane, Genes Dev., 30, 973, 10.1101/gad.276725.115

Huang, 2019, BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis, Cell Res., 29, 942, 10.1038/s41422-019-0231-y

Priault, 2003, Investigation of the role of the C-terminus of Bax and of tc-Bid on Bax interaction with yeast mitochondria, Cell Death Differ., 10, 1068, 10.1038/sj.cdd.4401270

Cartron, 2003, The N-terminal end of Bax contains a mitochondrial-targeting signal, J. Biol. Chem., 278, 11633, 10.1074/jbc.M208955200

Arokium, 2004, Studies of the interaction of substituted mutants of BAX with yeast mitochondria reveal that the C-terminal hydrophobic alpha-helix is a second ART sequence and plays a role in the interaction with anti-apoptotic BCL-xL, J. Biol. Chem., 279, 52566, 10.1074/jbc.M408373200

Simonyan, 2017, The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria, Biochim. Biophys. Acta, 1859, 1144, 10.1016/j.bbamem.2017.03.010

Alves, 2018, N-terminal acetylation modulates Bax targeting to mitochondria, Int. J. Biochem. Cell Biol., 95, 35, 10.1016/j.biocel.2017.12.004

Banadyga, 2011, Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax, J. Virol., 85, 1922, 10.1128/JVI.01959-10

Mentel, 2011, Reconstitution of interactions of Murine gammaherpesvirus 68 M11 with Bcl-2 family proteins in yeast, Bioch. Biophys. Res. Commun., 407, 783, 10.1016/j.bbrc.2011.03.100

Bloomer, 2016, Modeling Metazoan Apoptotic Pathways in Yeast, Methods Mol. Biol., 1419, 161, 10.1007/978-1-4939-3581-9_13

Forte, 2003, Response of yeast to the regulated expression of proteins in the Bcl-2 family, Biochem. J., 374, 393, 10.1042/bj20030690

Yin, 1994, BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax, Nature, 369, 321, 10.1038/369321a0

Sedlak, 1995, Multiple Bcl-2 family members demonstrate selective dimerizations with Bax, Proc. Natl. Acad. Sci. USA, 92, 7834, 10.1073/pnas.92.17.7834

Minn, 1999, Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms, EMBO J., 18, 632, 10.1093/emboj/18.3.632

Edlich, 2011, Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol, Cell, 145, 104, 10.1016/j.cell.2011.02.034

Renault, 2015, Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737, Int. J. Biochem. Cell Biol., 64, 136, 10.1016/j.biocel.2015.03.020

Renault, 2017, A brewing understanding of the regulation of Bax function by Bcl-xL and Bcl-2, Mech. Ageing Dev., 161, 201, 10.1016/j.mad.2016.04.007

Forte, 2013, BH3-only proteins Noxa, Bik, Bmf, and Bid activate Bax and Bak indirectly when studied in yeast model, FEMS Yeast Res., 13, 747, 10.1111/1567-1364.12074

Mentel, 2011, BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast, FEBS Lett., 585, 2709, 10.1016/j.febslet.2011.07.027

Wang, 1996, BID: A novel BH3 domain-only death agonist, Genes Dev., 10, 2859, 10.1101/gad.10.22.2859

Luo, 1998, Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors, Cell, 94, 481, 10.1016/S0092-8674(00)81589-5

Gross, 1999, Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-X-L prevents this release but not tumor necrosis factor-R1/Fas death, J. Biol. Chem., 274, 1156, 10.1074/jbc.274.2.1156

Guscetti, 2005, Functional characterization of human proapoptotic molecules in yeast S. cerevisiae, FASEB J., 19, 464, 10.1096/fj.04-2316fje

Weber, 2007, BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins, J. Cell Biol., 177, 625, 10.1083/jcb.200610148

Wilfling, 2012, BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax, Cell Death Differ., 19, 1328, 10.1038/cdd.2012.9

Gallenne, 2009, Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members, J. Cell Biol., 185, 279, 10.1083/jcb.200809153

Gavathiotis, 2008, BAX activation is initiated at a novel interaction site, Nature, 455, 1076, 10.1038/nature07396

Walensky, 2006, A stapled BID BH3 helix directly binds and activates BAX, Mol. Cell, 24, 199, 10.1016/j.molcel.2006.08.020

Buttner, 2011, A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis, EMBO J., 30, 2779, 10.1038/emboj.2011.197

Cebulski, J., Malouin, J., Pinches, N., Cascio, V., and Austriaco, N. (2011). Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae. PLoS ONE, 6.

Kelly, 2011, The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy, Cell Death Differ., 18, 1414, 10.1038/cdd.2011.17

Merino, 2018, BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines, Cancer Cell, 34, 879, 10.1016/j.ccell.2018.11.004

Green, 2016, A BH3 Mimetic for Killing Cancer Cells, Cell, 165, 1560, 10.1016/j.cell.2016.05.080

Beaumont, 2013, Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members, Cell Death Dis., 4, e619, 10.1038/cddis.2013.143

Zhai, 2006, Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins, Cell Death Differ., 13, 1419, 10.1038/sj.cdd.4401937

Doshi, 2007, Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis, Mol. Pharm., 4, 919, 10.1021/mp7000846