H 2 S Induces a Suspended Animation-Like State in Mice

American Association for the Advancement of Science (AAAS) - Tập 308 Số 5721 - Trang 518-518 - 2005
Eric Blackstone1,2, Mike Morrison1,2, Mark B. Roth1,2
1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98105, USA.
2Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 USA

Tóm tắt

Mammals normally maintain their core body temperature (CBT) despite changes in environmental temperature. Exceptions to this norm include suspended animation–like states such as hibernation, torpor, and estivation. These states are all characterized by marked decreases in metabolic rate, followed by a loss of homeothermic control in which the animal's CBT approaches that of the environment. We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse ( Mus musculus ). This state is readily reversible and does not appear to harm the animal. This suggests the possibility of inducing suspended animation-like states for medical applications.

Từ khóa


Tài liệu tham khảo

10.1152/physrev.00008.2003

10.1016/S0891-5849(01)00628-1

10.1073/pnas.131213198

10.1073/pnas.0403312101

10.1086/416717

10.3109/10408448409029321

Materials and methods are available as supporting online material on Science Online.

E. Blackstone M. Morrison M. B. Roth unpublished data.

10.1007/s003359900551

We thank J. Goldmark D. Miller K. Chan and A. J. Katzaroff for helpful discussion and commentary J. Blackwood for instruction on the installation of telemetry devices and Byrne Specialty Gases for gas science consultations. Supported by NIH grant no. GM48435 (M.R.) by donations to the Fred Hutchinson Cancer Research Center and by National Institute of Aging award no. T32 AG00057 (E.B.).

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 308 Số 5721

518-518

Thông tin tác giả