Involvement of the bcl -2 Gene in Human Follicular Lymphoma

American Association for the Advancement of Science (AAAS) - Tập 228 Số 4706 - Trang 1440-1443 - 1985
Yoshihide Tsujimoto1, Jeffrey Cossman2, Elaine S. Jaffe2, Carlo M. Croce3,1
1Wistar Institute, Philadelphia, Pennsylvania 19104
2Hematology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20205
3Department of Human Genetics, University of Pennsylvania School of Medicine. Philadelphia, Pennsylvania 19104

Tóm tắt

Recombinant DNA probes were cloned for the areas flanking the breakpoint on chromosome 18 in cells from a patient with acute lymphocytic leukemia of the B-cell type; cells of this line carry the t(14;18) chromosomal translocation. Two of the probes detected DNA rearrangements in approximately 60 percent of the cases of follicular lymphoma screened. In follicular lymphoma, most of the breakpoints in band q21 of chromosome 18 were clustered within a short stretch of DNA, approximately 2.1 kilobases in length. Chromosome 18-specific DNA probes for the areas flanking the breakpoints also detected RNA transcripts 6 kilobases in length in various cell types. The gene coding for these transcripts (the bcl -2 gene) seems to be interrupted in most cases of follicular lymphomas carrying the t(14;18) chromosomal translocation.

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American Association for the Advancement of Science (AAAS)

Tập 228 Số 4706

1440-1443

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