Yu Xin1, Zheng Li2, Heyi Zheng1, Jeffery Ho3, Matthew T.V. Chan3, William K.K. Wu3,4
1Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100042 China
2Department of Orthopedics Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100042 China
3Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong
4State Key Laboratory of Digestive Disease and LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong
Tóm tắt
AbstractNeuro‐oncological ventral antigen 1 (NOVA1) is a RNA‐binding protein that interacts with RNA containing repeats of the YCAY sequence. This protein is a brain‐specific splicing factor regulating neuronal alternative splicing. It has been increasingly recognized as an important contributor to neurological disorders and carcinogenesis. In this review, we summarize the biological functions and pathological roles of NOVA1. The clinical implications of NOVA1 will also be discussed.
