Fatal Cryptococcus gattii genotype AFLP6/VGII infection in a HIV‐negative patient: case report and a literature review

Mycoses - Tập 57 Số 10 - Trang 639-643 - 2014
Olívia Cometti Favalessa1, Márcia dos Santos Lazéra2, Bodo Wanke2, Luciana Trilles2, Doracilde Terumi Takahara1, Tomoko Tadano3, Luciana Basili Dias1, Ananda Castro Vieira3, Glaúcia Vanessa Novack3, Rosane Christine Hahn3,1
1Laboratório de Micologia Faculdade de Medicina Universidade Federal de Mato Grosso Cuiabá MT Brazil
2IPEC – Laboratório de Micologia FIOCRUZ Rio de Janeiro RJ Brazil
3Hospital Universitário Júlio Müller Universidade Federal de Mato Grosso Cuiabá MT Brazil

Tóm tắt

SummaryCryptococcus gattii, a species belonging to the Cryptococcus complex which occurs endemically in tropical and subtropical regions, has been reported as a causative agent of cryptococcosis in healthy individuals. We report a case of meningitis in HIV‐negative patient from Cuiaba, MT, in the Midwestern region of Brazil. Cryptococcus gattii AFLP6/VGII was isolated from cerebrospinal fluid and molecular typing was performed by URA5‐RFLP. The in vitro susceptibility profile was determined using the standard method according to the document M27A3, CLSI 2008. C. gattii AFLP6/VGII was shown to be susceptible to the antifungals tested. Treatment with 0.8 mg/kg of amphotericin B was initiated; however, the patient died 2 days after the onset of therapy.

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Mycoses

Tập 57 Số 10

639-643

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