Identification of a new member of the protegrin family by cDNA cloning

FEBS Letters - Tập 346 - Trang 285-288 - 1994
Chengquan Zhao1, Lide Liu1, Robert I. Lehrer1
1Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA 90024, USA

Tóm tắt

The porcine leukocyte protegrins are a family of cysteine‐rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG‐4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5′ and (in some instances) 3′ sequences present in structurally dissimilar antimicrobial and LPS‐binding peptides of animal leukocytes.

Tài liệu tham khảo

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Thông tin xuất bản

FEBS Letters

Tập 346

285-288

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