Chengquan Zhao1, Lide Liu1, Robert I. Lehrer1
1Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA 90024, USA
Tóm tắt
The porcine leukocyte protegrins are a family of cysteine‐rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG‐4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5′ and (in some instances) 3′ sequences present in structurally dissimilar antimicrobial and LPS‐binding peptides of animal leukocytes.
