Perspective on the safety and effectiveness of conjugated linoleic acid

The American Journal of Clinical Nutrition - Tập 79 - Trang 1132S-1136S - 2004
Michael W Pariza

Tài liệu tham khảo

Pariza, 1979, Effects of temperature and time on mutagen formation in pan-fried hamburger, Cancer Lett, 7, 63, 10.1016/S0304-3835(79)80097-X Pariza, 1985, A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene, Carcinogenesis, 6, 591, 10.1093/carcin/6.4.591 Ha, 1987, Anticarcinogens from fried ground beef: heat altered derivatives of linoleic acid, Carcinogenesis, 8, 1881, 10.1093/carcin/8.12.1881 Pariza, 2001, The biologically-active isomers of conjugated linoleic acid, Prog Lipid Res, 40, 283, 10.1016/S0163-7827(01)00008-X Henriksen, 2003, Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat, Am J Physiol, 285, E98 Belury, 2003, Conjugated linoleic acids in type 2 diabetes mellitus: implications and potential mechanisms, 2, 302 Noone, 2002, The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects, Br J Nutr, 88, 243, 10.1079/BJN2002615 Nagao, 2003, The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats, Biochem Biophys Res Comm, 306, 134, 10.1016/S0006-291X(03)00929-X Kritchevsky, 2003, Conjugated linoleic acid in experimental atherosclerosis, 2, 293 Atkinson RL, Whigham LD. Effects of CLA on body composition and metabolic variables in humans. Internet: http://www.aocs.org/archives/am2003/session.asp?strsession=ana1(accessed 1 August 2003). Albers, 2003, Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men, Eur J Clin Nutr, 57, 595, 10.1038/sj.ejcn.1601585 Bassaganya-Riera, 2003, Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression, J Nutr, 133, 3204, 10.1093/jn/133.10.3204 Whigham, 2002, Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs, Am J Physiol, 282, R1104 Miller, 1994, Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection, Biochem Biophys Res Comm, 198, 1107, 10.1006/bbrc.1994.1157 Whigham, 2001, CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae, Am J Physiol, 280, R908 Cook, 1993, Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression, Poultry Sci, 72, 1301, 10.3382/ps.0721301 Bassaganya-Riera, 2002, Colonic anti-inflammatory mechanisms of conjugated linoleic acid, Clin Nutr, 21, 451, 10.1054/clnu.2002.0594 Park, 1999, Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice, Lipids, 34, 235, 10.1007/s11745-999-0358-8 Ip, 2002, Conjugated linoleic acid isomers and mammary cancer prevention, Nutr Cancer, 43, 52, 10.1207/S15327914NC431_6 Masso-Welch, 2002, Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid, Cancer Res, 62, 4383 Kemp, 2003, Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells, J Nutr, 133, 3670, 10.1093/jn/133.11.3670 Pariza, 2003, Speculation on the mechanisms of action of conjugated linoleic acid, 2, 251 Roche, 2002, Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXR, Diabetes, 51, 2037, 10.2337/diabetes.51.7.2037 Park, 1997, Effect of conjugated linoleic acid on body composition in mice, Lipids, 32, 853, 10.1007/s11745-997-0109-x Kang, 2003, trans-10,cis-12 CLA inhibits differentiation of 3T3–L1 adipocytes and decreases PPAR gamma expression, Biochem Biophys Res Comm, 303, 795, 10.1016/S0006-291X(03)00413-3 Xu, 2003, Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue, J Nutr, 133, 663, 10.1093/jn/133.3.663 Nagao, 2003, The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats, Nutrition, 19, 652, 10.1016/S0899-9007(03)00060-1 Brown, 2003, Isomer-specific regulation of metabolism and PPAR signaling by CLA in human preadipocytes, J Lipid Res, 44, 1287, 10.1194/jlr.M300001-JLR200 Brown, 2003, Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity, J Nutr, 133, 3041, 10.1093/jn/133.10.3041 Kim, 2002, Differential responses of hamsters and rats fed high-fat or low-fat diets supplemented with conjugated linoleic acid, Nutr Res, 22, 715, 10.1016/S0271-5317(02)00372-X Ostrowska, 2003, Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy X-ray absorptiometry, J Nutr, 89, 219, 10.1079/BJN2002765 Gaullier, 2002, Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies, Lipids, 37, 1019, 10.1007/s11745-002-0995-y Kamphuis, 2003, The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects, Int J Obesity, 27, 840, 10.1038/sj.ijo.0802304 Kamphuis, 2003, Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects, Eur J Clin Nutr, 57, 1268, 10.1038/sj.ejcn.1601684 Scimeca, 1998, Toxicological evaluation of dietary conjugated linoleic acid in male Fischer 344 rats, Food Chem Toxicol, 36, 391, 10.1016/S0278-6915(97)00169-5 O'Hagan, 2003, A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product, Food Chem Toxicol, 41, 1749, 10.1016/S0278-6915(03)00203-5 Schulte S, Hasselwander O, RensmannF-W, Kaesler B, Pfeiffer AM. Safety assessment of conjugated linoleic acid (CLA) esters in the future application field as a feed additive in growing pigs. Internet: http://www.aocs.org/archives/am2003/session.asp?strsession=ana2(accessed 1 August 2003). Pfeiffer AM, Kaufmann W, Braun J, Kaesler B. Target animal safety of conjugated linoleic acid (CLA) on young growing pigs. Internet: http://www.aocs.org/archives/am2003/session.asp?strsession=ana2(accessed 1 August 2003). Kelley, 2003, Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks, Lipids, 38, 377, 10.1007/s11745-003-1072-2 Larsen, 2003, Efficacy and safety of dietary supplements containing conjugated linoleic acid (CLA) for the treatment of obesity: evidence from animal and human studies, J Lipid Res, 44, 2234, 10.1194/jlr.R300011-JLR200 Riserus, 2002, Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance, Circulation, 106, 1925, 10.1161/01.CIR.0000033589.15413.48 Plaa, 1986, Toxic responses of the liver, 286 DeLany, 1999, Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake, Am J Physiol, 276, R1172 Hamura, 2001, Long-term administration of glycerides rich in conjugated linoleic acid (CLA) to diabetic C57BLKS-Leprdb/leprdb(db/db) mice, J Oleo Sci, 50, 883, 10.5650/jos.50.883 Hamura, 2001, Glycerides rich in conjugated linoleic acid (CLA) improve blood glucose control in diabetic C57BLKS-Leprdb/leprdb(db/db) mice, J Oleo Sci, 50, 889, 10.5650/jos.50.889 Tsuboyama-Kasaoka, 2003, Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice, J Nutr, 133, 1793, 10.1093/jn/133.6.1793 Yang, 2000, Dietary conjugated linoleic acid protects against end stage disease of systematic lupus erythematosus in the NZB/W F1 mouse, Immunopharm Immunotox, 22, 433, 10.3109/08923970009026004 Yang, 2003, Dietary CLA decreased weight loss and extended survival following outset of kidney failure in NZB/WF1 mice, Lipids, 38, 21, 10.1007/s11745-003-1026-8 Lee, 1994, Conjugated linoleic acid and atherosclerosis in rabbits, Atherosclerosis, 108, 19, 10.1016/0021-9150(94)90034-5 Toomey, 2003, Regression of pre-established atherosclerosis in the apoE(−/−) mouse by conjugated linoleic acid, Biochem Soc Trans, 31, 1075, 10.1042/bst0311075 Riserus, 2001, Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial, Int J Obes Relat Metab Disord, 25, 1129, 10.1038/sj.ijo.0801659 Peterson, 2003, Diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 CLA in milk fat and coordinate suppression of mRNA abundance for mammary enzymes involved in milk fat synthesis, J Nutr, 133, 3098, 10.1093/jn/133.10.3098 Masters, 2002, Maternal supplementation with CLA decreases milk fat in humans, Lipids, 37, 133, 10.1007/s11745-002-0872-8 Chin, 1994, Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency, J Nutr, 124, 2344, 10.1093/jn/124.12.2344 Bee, 2000, Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs, J Nutr, 130, 2981, 10.1093/jn/130.12.2981