Oleuropein reduces free fatty acid-induced lipogenesis via lowered extracellular signal-regulated kinase activation in hepatocytes

Nutrition Research - Tập 32 Số 10 - Trang 778-786 - 2012
Wonhee Hur1, Sung Woo Kim1, Young Ki Lee1, Jung Eun Choi1, Sung Woo Hong1, Myeong Jun Song1, Si Hyun Bae1, Taesun Park2, Soo‐Jong Um3, Seung Kew Yoon1
1WHO Collaborating Center of Viral Hepatitis and Department of Internal Medicine College of Medicine, the Catholic University of Korea, Republic of Korea
2Department of Food and Nutrition, Yonsei University, Republic of Korea
3Department of Bioscience and Biotechnology/Institute of Bioscience, Sejong University, Republic of Korea

Tóm tắt

Từ khóa


Tài liệu tham khảo

Lazo, 2008, The epidemiology of nonalcoholic fatty liver disease: a global perspective, Semin Liver Dis, 28, 339, 10.1055/s-0028-1091978

Lewis, 2010, Nonalcoholic fatty liver disease: a review and update, Dig Dis Sci, 55, 560, 10.1007/s10620-009-1081-0

Day, 2002, NASH-related liver failure: one hit too many?, Am J Gastroenterol, 97, 1872, 10.1111/j.1572-0241.2002.05952.x

Day, 1998, Steatohepatitis: a tale of two “hits”?, Gastroenterology, 114, 842, 10.1016/S0016-5085(98)70599-2

Waterman, 2007, Active components and clinical applications of olive oil, Altern Med Rev, 12, 331

Owen, 2000, The antioxidant/anticancer potential of phenolic compounds isolated from olive oil, Eur J Cancer, 36, 1235, 10.1016/S0959-8049(00)00103-9

Owen, 2000, Olive-oil consumption and health: the possible role of antioxidants, Lancet Oncol, 1, 107, 10.1016/S1470-2045(00)00015-2

Corona, 2006, The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation, Free Radic Res, 40, 647, 10.1080/10715760500373000

Poudyal, 2010, Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats, J Nutr, 140, 946, 10.3945/jn.109.117812

Park, 2011, Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice, J Hepatol, 54, 984, 10.1016/j.jhep.2010.08.019

Yamashita, 2005, Effects of dehydroepiandrosterone on gluconeogenic enzymes and glucose uptake in human hepatoma cell line, HepG2, Endocr J, 52, 727, 10.1507/endocrj.52.727

Gomez-Lechon, 2007, A human hepatocellular in vitro model to investigate steatosis, Chem Biol Interact, 165, 106, 10.1016/j.cbi.2006.11.004

Vermes, 2000, Flow cytometry of apoptotic cell death, J Immunol Methods, 243, 167, 10.1016/S0022-1759(00)00233-7

McMillian, 2001, Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis, In Vitr Mol Toxicol, 14, 177, 10.1089/109793301753407948

Greenspan, 1985, Spectrofluorometric studies of the lipid probe, nile red, J Lipid Res, 26, 781, 10.1016/S0022-2275(20)34307-8

Greenspan, 1985, Nile red: a selective fluorescent stain for intracellular lipid droplets, J Cell Biol, 100, 965, 10.1083/jcb.100.3.965

Wang, 2003, Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity, Cell, 113, 159, 10.1016/S0092-8674(03)00269-1

Sanyal, 2001, Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities, Gastroenterology, 120, 1183, 10.1053/gast.2001.23256

Ruddock, 2008, Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling, J Biochem, 144, 599, 10.1093/jb/mvn105

Ryan, 2000, Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity, QJM, 93, 85, 10.1093/qjmed/93.2.85

Eitel, 2002, Different role of saturated and unsaturated fatty acids in beta-cell apoptosis, Biochem Biophys Res Commun, 299, 853, 10.1016/S0006-291X(02)02752-3

Hernandez, 2005, Molecular cloning and characterization of genes encoding two microsomal oleatedesaturases (FAD2) from olive, Phytochemistry, 66, 1417, 10.1016/j.phytochem.2005.04.004

Malhi, 2006, Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis, J Biol Chem, 281, 12093, 10.1074/jbc.M510660200

Listenberger, 2003, Triglyceride accumulation protects against fatty acid-induced lipotoxicity, Proc Natl Acad Sci USA, 100, 3077, 10.1073/pnas.0630588100

Vissers, 2004, Bioavailability and antioxidant effects of olive oil phenols in humans: a review, Eur J Clin Nutr, 58, 955, 10.1038/sj.ejcn.1601917

Santiago-Mora, 2011, Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow, Osteoporos Int, 22, 675, 10.1007/s00198-010-1270-x

Park, 2010, Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice, J Hepatol, 2, 55

Ducharme, 2008, Lipid droplets in lipogenesis and lipolysis, Endocrinology, 149, 942, 10.1210/en.2007-1713

Ip, 1998, Signal transduction by the c-Jun N-terminal kinase (JNK)—from inflammation to development, Curr Opin Cell Biol, 10, 205, 10.1016/S0955-0674(98)80143-9

Robinson, 1997, Mitogen-activated protein kinase pathways, Curr Opin Cell Biol, 9, 180, 10.1016/S0955-0674(97)80061-0

Widmann, 1999, Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human, Physiol Rev, 79, 143, 10.1152/physrev.1999.79.1.143

Weston, 2007, The JNK signal transduction pathway, Curr Opin Cell Biol, 19, 142, 10.1016/j.ceb.2007.02.001

Solinas, 2006, Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates, Proc Natl Acad Sci USA, 103, 16454, 10.1073/pnas.0607626103

Leonardini, 2009, Cross-talk between PPARgamma and insulin signaling and modulation of insulin sensitivity, PPAR Res, 2009, 818945, 10.1155/2009/818945