Microglia activation in retinal degeneration

Schuetz, 2004, Microglia-targeted pharmacotherapy in retinal neurodegenerative diseases., Curr. Drug Targets, 5, 619, 10.2174/1389450043345164

Kreutzberg, 1996, Microglia: a sensor for pathological events in the CNS., Trends Neurosci., 19, 312, 10.1016/0166-2236(96)10049-7

Streit, 2002, Microglia as neuroprotective, immunocompetent cells of the CNS., Glia, 40, 133, 10.1002/glia.10154

van Rossum, 2004, Microglia., Metab. Brain Dis., 19, 393, 10.1023/B:MEBR.0000043984.73063.d8

Kim, 2006, Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson’s disease., Exp. Mol. Med., 38, 333, 10.1038/emm.2006.40

Oehmichen, 1982, Are resting and/or reactive microglia macrophages?, Immunobiology, 161, 246, 10.1016/S0171-2985(82)80080-6

Barron, 1995, The microglial cell. A historical review., J. Neurol. Sci., 134, 57, 10.1016/0022-510X(95)00209-K

Rezaie, 1999, Colonization of the developing human brain and spinal cord by microglia: a review., Microsc. Res. Tech., 45, 359, 10.1002/(SICI)1097-0029(19990615)45:6<359::AID-JEMT4>3.0.CO;2-D

Hume, 1983, Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers., J. Cell Biol., 97, 253, 10.1083/jcb.97.1.253

Frade, 1998, Microglia-derived nerve growth factor causes cell death in the developing retina., Neuron, 20, 35, 10.1016/S0896-6273(00)80432-8

Lobov, 2005, WNT7b mediates macrophageinduced programmed cell death in patterning of the vasculature., Nature, 437, 417, 10.1038/nature03928

Bessis, 2007, Microglial control of neuronal death and synaptic properties., Glia, 55, 233, 10.1002/glia.20459

Roumier, 2004, Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse., J. Neurosci., 24, 11421, 10.1523/JNEUROSCI.2251-04.2004

Takahashi, 2005, Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2., J. Exp. Med., 201, 647, 10.1084/jem.20041611

Klesney-Tait, 2006, The TREM receptor family and signal integration., Nat. Immunol., 7, 1266, 10.1038/ni1411

Husemann, 2002, Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system., Glia, 40, 195, 10.1002/glia.10148

Perry, 1988, Macrophages and microglia in the nervous system., Trends Neurosci., 11, 273, 10.1016/0166-2236(88)90110-5

Schmidtmayer, 1994, Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: membrane currents., Glia, 12, 259, 10.1002/glia.440120403

Bodeutsch, 2000, Migration of phagocytotic cells and development of the murine intraretinal microglial network: an in vivo study using fluorescent dyes., Glia, 32, 91, 10.1002/1098-1136(200010)32:1<91::AID-GLIA90>3.0.CO;2-X

Thanos, 1991, The relationship of microglial cells to dying neurons during natural neuronal cell death and axotomy-induced degeneration of the rat retina., Eur. J. Neurosci., 3, 1189, 10.1111/j.1460-9568.1991.tb00054.x

Thanos, 1994, Old dyes for new scopes: the phagocytosis-dependent long-term fluorescence labeling of microglial cells in vivo., Trends Neurosci., 17, 177, 10.1016/0166-2236(94)90098-1

Albini, 2005, Microglial stability and repopulation in the retina., Br. J. Ophthalmol., 89, 901, 10.1136/bjo.2004.060293

Kennedy, 1997, Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model., Blood, 90, 986, 10.1182/blood.V90.3.986

Kennedy, 1998, Mature monocytic cells enter tissues and engraft., Proc. Natl. Acad. Sci. USA, 95, 14944, 10.1073/pnas.95.25.14944

Dick, 2003, Control of myeloid activity during retinal inflammation., J. Leukoc. Biol., 74, 161, 10.1189/jlb.1102535

D’Orazio, 1998, A novel role for TGF-β and IL-10 in the induction of immune privilege., J. Immunol., 160, 2089, 10.4049/jimmunol.160.5.2089

Paglinawan, 2003, TGFβ directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes., Glia, 44, 219, 10.1002/glia.10286

Nathan, 2001, Putting the brakes on innate immunity: a regulatory role for CD200?, Nat. Immunol., 2, 17, 10.1038/83124

Clark, 1985, MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain., EMBO J., 4, 113, 10.1002/j.1460-2075.1985.tb02324.x

McCaughan, 1987, Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein., Immunogenetics, 25, 329, 10.1007/BF00404426

Hoek, 2000, Down-regulation of the macrophage lineage through interaction with OX2 (CD200)., Science, 290, 1768, 10.1126/science.290.5497.1768

Wright, 2000, Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function., Immunity, 13, 233, 10.1016/S1074-7613(00)00023-6

Dick, 2001, Distribution of OX2 antigen and OX2 receptor within retina., Invest. Ophthalmol. Vis. Sci., 42, 170

Carter, 2004, CD200 maintains microglial potential to migrate in adult human retinal explant model., Curr. Eye Res., 28, 427, 10.1080/02713680490503778

Carwile, 1998, Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF., Exp. Eye Res., 66, 791, 10.1006/exer.1998.0488

Harada, 2003, Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration., Neuroscience, 122, 229, 10.1016/S0306-4522(03)00599-2

Yin, 2003, Macrophage-derived factors stimulate optic nerve regeneration., J. Neurosci., 23, 2284, 10.1523/JNEUROSCI.23-06-02284.2003

Yin, 2006, Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells., Nat. Neurosci., 9, 843, 10.1038/nn1701

Nimmerjahn, 2005, Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo., Science, 308, 1314, 10.1126/science.1110647

Cardona, 2006, Control of microglial neurotoxicity by the fractalkine receptor., Nat. Neurosci., 9, 917, 10.1038/nn1715

Lehrmann, 1998, Microglia and macrophages are major sources of locally produced transforming growth factor-β1 after transient middle cerebral artery occlusion in rats., Glia, 24, 437, 10.1002/(SICI)1098-1136(199812)24:4<437::AID-GLIA9>3.0.CO;2-X

Bazan, 1997, A new class of membranebound chemokine with a CX3C motif., Nature, 385, 640, 10.1038/385640a0

Haynes, 2006, The P2Y12 receptor regulates microglial activation by extracellular nucleotides., Nat. Neurosci., 9, 1512, 10.1038/nn1805

Fries, 2004, Expression of P2Y1, P2Y2, P2Y4, and P2Y6 receptor subtypes in the rat retina., Invest. Ophthalmol. Vis. Sci., 45, 3410, 10.1167/iovs.04-0141

Hanisch, 2002, Microglia as a source and target of cytokines., Glia, 40, 140, 10.1002/glia.10161

Streit, 1999, Reactive microgliosis., Prog. Neurobiol., 57, 563, 10.1016/S0301-0082(98)00069-0

Zeiss, 2004, Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse., Invest. Ophthalmol. Vis. Sci., 45, 971, 10.1167/iovs.03-0301

Zeng, 2005, Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice., Invest. Ophthalmol. Vis. Sci., 46, 2992, 10.1167/iovs.05-0118

Gehrig, 2007, Genome-wide expression profiling of the retinoschisin-deficient retina in early postnatal mouse development., Invest. Ophthalmol. Vis. Sci., 48, 891, 10.1167/iovs.06-0641

Weber, 2002, Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure., Proc. Natl. Acad. Sci. USA, 99, 6222, 10.1073/pnas.092528599

Gehrig, 2006, The role of caspases in photoreceptor cell death of the retinoschisin-deficient mouse., Cytogenet. Genome Res., 115, 35, 10.1159/000094799

Lee, 2001, Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11., J. Biol. Chem., 276, 32956, 10.1074/jbc.M104700200

Nakamura, 2002, Regulating factors for microglial activation., Biol. Pharm. Bull., 25, 945, 10.1248/bpb.25.945

Chen, 2004, Light damage induced changes in mouse retinal gene expression., Exp. Eye Res., 79, 239, 10.1016/j.exer.2004.05.002

Ahmed, 2004, Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure., Invest. Ophthalmol. Vis. Sci., 45, 1247, 10.1167/iovs.03-1123

Steele, 2006, Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma., Invest. Ophthalmol. Vis. Sci., 47, 977, 10.1167/iovs.05-0865

Vazquez-Chona, 2004, Temporal changes in gene expression after injury in the rat retina., Invest. Ophthalmol. Vis. Sci., 45, 2737, 10.1167/iovs.03-1047

Wada, 2000, Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation., Proc. Natl. Acad. Sci. USA, 97, 10954, 10.1073/pnas.97.20.10954

Ohmi, 2003, Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB., Proc. Natl. Acad. Sci. USA, 100, 1902, 10.1073/pnas.252784899

Roque, 1993, Isolation and culture of retinal microglia., Curr. Eye Res., 12, 285, 10.3109/02713689308999475

Mitrasinovic, 2001, Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response., J. Biol. Chem., 276, 30142, 10.1074/jbc.M104265200

Imai, 2002, Intracellular signaling in M-CSF-induced microglia activation: role of Iba1., Glia, 40, 164, 10.1002/glia.10149

Roque, 1999, Retina-derived microglial cells induce photoreceptor cell death in vitro., Brain Res., 836, 110, 10.1016/S0006-8993(99)01625-X

Srinivasan, 2004, Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor., J. Biol. Chem., 279, 41839, 10.1074/jbc.M402872200

Tan, 2004, Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice., Invest. Ophthalmol. Vis. Sci., 45, 764, 10.1167/iovs.03-1114

Nagai, 2005, Immortalized human microglial cell line: phenotypic expression., J. Neurosci. Res., 81, 342, 10.1002/jnr.20478

Block, 2007, Microglia-mediated neurotoxicity: uncovering the molecular mechanisms., Nat. Rev. Neurosci., 8, 57, 10.1038/nrn2038

Mollen, 2006, Emerging paradigm: Toll-like receptor 4-sentinel for the detection of tissue damage., Shock, 26, 430, 10.1097/01.shk.0000228797.41044.08

Tanga, 2005, The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy., Proc. Natl. Acad. Sci. USA, 102, 5856, 10.1073/pnas.0501634102

Lehnardt, 2003, Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway., Proc. Natl. Acad. Sci. USA, 100, 8514, 10.1073/pnas.1432609100

Jung, 2005, TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-β as a decision maker., J. Immunol., 174, 6467, 10.4049/jimmunol.174.10.6467

Hu, 2006, Egr1 gene knockdown affects embryonic ocular development in zebrafish., Mol. Vis., 12, 1250

Schippert, 2007, Relative axial myopia in Egr-1 (ZENK) knockout mice., Invest. Ophthalmol. Vis. Sci., 48, 11, 10.1167/iovs.06-0851

Laslo, 2006, Multilineage transcriptional priming and determination of alternate hematopoietic cell fates., Cell, 126, 755, 10.1016/j.cell.2006.06.052