The Global Alzheimer's Association Interactive Network

Alzheimer's & Dementia - Tập 12 - Trang 49-54 - 2016
Arthur W. Toga1, Scott C. Neu1, Priya Bhatt1, Karen L. Crawford1, Naveen Ashish1
1Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Tóm tắt

AbstractIntroduction

The Global Alzheimer's Association Interactive Network (GAAIN) is consolidating the efforts of independent Alzheimer's disease data repositories around the world with the goals of revealing more insights into the causes of Alzheimer's disease, improving treatments, and designing preventative measures that delay the onset of physical symptoms.

Methods

We developed a system for federating these repositories that is reliant on the tenets that (1) its participants require incentives to join, (2) joining the network is not disruptive to existing repository systems, and (3) the data ownership rights of its members are protected.

Results

We are currently in various phases of recruitment with over 55 data repositories in North America, Europe, Asia, and Australia and can presently query >250,000 subjects using GAAIN's search interfaces.

Discussion

GAAIN's data sharing philosophy, which guided our architectural choices, is conducive to motivating membership in a voluntary data sharing network.


Tài liệu tham khảo

Husain M, 2014, Big data: Could it ever cure Alzheimer's disease?, Brain, 137, 2623, 10.1093/brain/awu245 KolataG.New research looks for cures in mutations.The New York Times2014;A1 10.1016/j.jalz.2010.03.001 10.1016/j.nic.2011.11.008 10.1016/j.jalz.2010.03.007 10.1016/j.pneurobio.2011.09.005 Burton A, 2011, Big science for a big problem: ADNI enters its second phase, Lancet Neurol, 10, 206, 10.1016/S1474-4422(11)70031-X 10.1016/j.jalz.2013.05.1769 10.1038/78728 Marshall E, 2000, A ruckus over releasing images of the human brain, Science, 289, 1458, 10.1126/science.289.5484.1458 10.1038/nrn787 Ventura B, 2005, Mandatory submission of microarray data to public repositories: How is it working?, Physiol Genomics, 20, 153, 10.1152/physiolgenomics.00264.2004 10.1371/journal.pone.0018657 10.1100/tsw.2009.57 10.1016/j.ecoinf.2012.03.004 10.1007/s12021-012-9151-4 10.1016/j.neuroimage.2015.05.082 10.1080/00223980.1945.9917223 Spinnler H, 1987, Taratura e standardizzazione italiana di test neuropsicologici, Italian Journal of Neurological Sciences, 8, 8 Novelli G, 1986, Tre test clinici di memoria verbale a lungo termine. Tarattura su soggetti normali [Normative values of three tests of verbal long‐term memory], Arch Psicol Neurol Psichiatria, 47, 278 10.1002/ana.21610 10.1007/s00401-012-0983-7 10.1093/brain/awp007 10.1212/WNL.48.5.1297 Kuchinke W, 2009, CDISC standard‐based electronic archiving of clinical trials, Methods Inf Med, 48, 408, 10.3414/ME9236 10.1136/jamia.2009.002063 10.1007/978-3-642-31164-2