Age‐related EBV‐associated B‐cell lymphoproliferative disorders: Diagnostic approach to a newly recognized clinicopathological entity

Pathology International - Tập 59 Số 12 - Trang 835-843 - 2009
Yoshie Shimoyama1, Naoko Asano2, Masaru Kojima3, Satoko Morishima4, Kazuhito Yamamoto5, Takashi Oyama6, Tomohiro Kinoshita7, Shigeo Nakamura8
1Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan
2Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto and
3Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University, Mibu, Japan
4Division of Immunology, Aichi Cancer Center Research Institute,
5Department of Hematology and Chemotherapy, Aichi Cancer Center,
6Department of Hematology, Nagoya Daini Red Cross Hospital,
7Department of Hematology, Nagoya University School of Medicine, Nagoya,
8Department of Pathology and Laboratory Medicine, Nagoya University Hospital.

Tóm tắt

EBV is prevalent among healthy individuals, and is implicated in numerous reactive and neoplastic processes in the immune system. The authors originally identified a series of senile or age‐related EBV‐associated B‐cell lymphoproliferative disorders (LPD) bearing a resemblance to immunodeficiency‐associated ones, which may be associated with immune senescence in the elderly and which are now incorporated into the 2008 World Health Organization lymphoma classification as EBV‐positive diffuse large B‐cell lymphoma (DLBCL) of the elderly. This newly described disease is pathologically characterized by a proliferation of atypical large B cells including Reed–Sternberg‐like cells with reactive components, which pose a diagnostic problem for pathologists. Clinically, this disease may present with lymphadenopathy, and is often extranodal, frequently involving the skin, gastrointestinal tract, or lung. Onset is usually after the age of 50; the median patient age is 70–79 years, and incidence continues to increase with age, providing additional support to the nosological term of EBV+ DLBCL of the elderly. These patients have a worse prognosis than those with EBV‐negative DLBCL or EBV+ classical Hodgkin lymphoma (CHL). The aim of the present review was to summarize the clinicopathological profile of age‐related EBV+ LPD and EBV+ Hodgkin lymphoma to facilitate diagnostic approach.

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Pathology International

Tập 59 Số 12

835-843

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