Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

FEBS Letters - Tập 231 - Trang 440-444 - 1988
Yasuaki Itoh1, Masashi Yanagisawa2, Shoichi Ohkubo1, Chiharu Kimura1, Takuo Kosaka1, Akihiro Inoue2, Norio Ishida3, Youji Mitsui3, Haruo Onda1, Masahiko Fujino1, Tomoh Masaki2
1Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan
2Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan
3Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan

Tóm tắt

A cDNA encoding a human endothelium‐derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

Tài liệu tham khảo

Yanagisawa M., 1988, Nature 10.1126/science.322279 10.1016/B978-0-444-01082-7.50026-6 10.1073/pnas.74.12.5463 10.1016/0014-4827(87)90096-6 10.1093/nar/12.2.857 1978 National Biomedical Research Foundation Silver Spring MD M.O. Dayhoff R.M. Schwartz B.C. Orcutt M.O. Dayhoff Atlas of Protein Sequence and Structure 345 352 10.1093/nar/14.11.4683 10.1073/pnas.78.6.3824
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FEBS Letters

Tập 231

440-444

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