Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro

Blood - Tập 123 - Trang 687-696 - 2014
Ali Danesh1,2, Heather C. Inglis1, Rachael P. Jackman1, Shiquan Wu1, Xutao Deng1, Marcus O. Muench1,2, John W. Heitman1, Philip J. Norris1,2,3
1Blood Systems Research Institute, San Francisco, CA
2Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA
3Department of Medicine, University of California San Francisco, San Francisco, CA

Tóm tắt

Key PointsExosomes in blood are proinflammatory and may contribute to transfusion-related immune modulation. Exosomes act via antigen-presenting cells to potentiate T-cell survival and mitogen-induced proliferation.

Tài liệu tham khảo

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