Sage Tea Drinking Improves Lipid Profile and Antioxidant Defences in Humans

International Journal of Molecular Sciences - Tập 10 Số 9 - Trang 3937-3950
Carla M. Sá1, Alice A. Ramos1, Marisa Frasson de Azevedo1, Cristóvão F. Lima2, Manuel Fernandes‐Ferreira2, Cristina Pereira‐Wilson1
1CBMA–Centre of Molecular and Environmental Biology/Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
2CITAB–Centre for the Research and Technology of Agro-Environment and Biological Sciences/Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal

Tóm tắt

Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes’ SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma glucose. An improvement in lipid profile was observed with lower plasma LDL cholesterol and total cholesterol levels as well as higher plasma HDL cholesterol levels during and two weeks after treatment. Sage tea also increased lymphocyte Hsp70 expression and erythrocyte SOD and CAT activities. No hepatotoxic effects or other adverse effects were observed.

Từ khóa


Tài liệu tham khảo

Williams, G, and Pickup, JC (2004). Handbook of Diabetes, Blackwell Publishing Ltd. [3rd ed].

Moller, 2001, New drug targets for type 2 diabetes and the metabolic syndrome, Nature, 414, 821, 10.1038/414821a

Saxena, 2005, Postprandial hypertriglyceridemia and oxidative stress in patients of type 2 diabetes mellitus with macrovascular complications, Clin. Chim. Acta, 359, 101, 10.1016/j.cccn.2005.03.036

Toth, 2005, High-density lipoprotein as a therapeutic target: Clinical evidence and treatment strategies, Am. J. Cardiol, 96, 50K, 10.1016/j.amjcard.2005.08.008

Veiraiah, 2005, Hyperglycemia, lipoprotein glycation, and vascular disease, Angiology, 56, 431, 10.1177/000331970505600411

Celik, 2008, Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats, Nat. Prod. Res, 22, 66, 10.1080/14786410701590426

Castro, 1999, Antioxidant enzymes and human diseases, Clin. Biochem, 32, 595, 10.1016/S0009-9120(99)00075-2

Feder, 1999, Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology, Annu. Rev. Physiol, 61, 243, 10.1146/annurev.physiol.61.1.243

Bonassi, 2002, Biomarkers in molecular epidemiology studies for health risk prediction, Mutat. Res., 511, 73, 10.1016/S1383-5742(02)00003-0

Jin, 2004, Serum and lymphocyte levels of heat shock protein 70 in aging: A study in the normal Chinese population, Cell Stress Chaperon, 9, 69, 10.1379/1466-1268(2004)009<0069:SALLOH>2.0.CO;2

Costacou, 2003, Nutrition and prevention of type 2 diabetes, Annu. Rev. Nutr., 23, 147, 10.1146/annurev.nutr.23.011702.073027

Gruber, 2006, Diabetes prevention: Is there more to it than lifestyle changes?, Int. J. Clin. Pract, 60, 590, 10.1111/j.1368-5031.2006.00929.x

Jermendy, 2005, Can type 2 diabetes mellitus be considered preventable?, Diabetes Res. Clin. Pract, 68, S73, 10.1016/j.diabres.2005.03.010

Fernandes, 2007, An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract, BMC Complement Altern. Med., 24, 7

Kumar, 1993, Hypoglycaemic effect of Coccinia indica: Mechanism of action, Planta Med, 59, 330, 10.1055/s-2006-959693

Venkateswaran, 2003, Effect of Coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats, J. Ethnopharmacol, 84, 163, 10.1016/S0378-8741(02)00294-5

Coimbra, 2006, Green tea consumption improves plasma lipid profile in adults, Nutr. Res, 26, 604, 10.1016/j.nutres.2006.09.014

Coimbra, 2006, The effect of green tea in oxidative stress, Clin. Nutr, 25, 790, 10.1016/j.clnu.2006.01.022

Polychronopoulos, 2008, Effects of black and green tea consumption on blood glucose levels in non-obese elderly men and women from Mediterranean Islands (MEDIS epidemiological study), Eur. J. Nutr, 47, 10, 10.1007/s00394-007-0690-7

2002, Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice, Phytother. Res, 16, 383, 10.1002/ptr.914

Eidi, 2005, Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats, J. Ethnopharmacol, 100, 310, 10.1016/j.jep.2005.03.008

Lima, 2006, Metformin-like effects of Salvia officinalis (common sage): Is it useful in diabetes prevention?, Br. J. Nutr., 96, 326, 10.1079/BJN20061832

Jamal, 1999, Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United States, Hepatology, 30, 1307, 10.1002/hep.510300526

Kim, 2004, Normal serum aminotransferase concentration and risk of mortality from liver diseases: Prospective cohort study, BMJ, 328, 983, 10.1136/bmj.38050.593634.63

Ravel, R (1989). Clinical Laboratory Medicine: Clinical Application of Laboratory Data, Mosby-Year Book Inc. [5th ed].

Sullivan, 2002, Screening for cardiovascular disease with cholesterol, Clin. Chim. Acta, 315, 49, 10.1016/S0009-8981(01)00720-3

Nesto, 2005, Beyond low-density lipoprotein: Addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndrome, Am. J. Cardiovasc. Drugs, 5, 379, 10.2165/00129784-200505060-00005

Plana, 2008, Plant sterol-enriched fermented milk enhances the attainment of LDL-cholesterol goal in hypercholesterolemic subjects, Eur. J. Nutr, 47, 32, 10.1007/s00394-007-0693-4

Raederstorff, 2003, Effect of EGCG on lipid absorption and plasma lipid levels in rats, J. Nutr. Biochem, 14, 326, 10.1016/S0955-2863(03)00054-8

Chen, 2001, Salvia miltiorrhiza inhibits intimal hyperplasia and monocyte chemotactic protein-1 expression after balloon injury in cholesterol-fed rabbits, J. Cell Biochem, 83, 484, 10.1002/jcb.1233

Scalbert, 2005, Dietary polyphenols and the prevention of diseases, Crit. Rev. Food Sci. Nutr, 45, 287, 10.1080/1040869059096

Lima, 2005, The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats, J. Ethnopharmacol, 97, 383, 10.1016/j.jep.2004.11.029

Lima, 2006, Phenolic compounds protect HepG2 cells from oxidative damage: Relevance of glutathione levels, Life Sci, 79, 2056, 10.1016/j.lfs.2006.06.042

Lima, 2007, Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage, Chem. Biol. Interact, 167, 107, 10.1016/j.cbi.2007.01.020

Lima, 2007, Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice, Food Chem. Toxicol, 45, 456, 10.1016/j.fct.2006.09.009

Gabai, 1997, Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance, J. Biol. Chem, 272, 18033, 10.1074/jbc.272.29.18033

McCarty, 2006, Induction of heat shock proteins may combat insulin resistance, Med. Hypotheses, 66, 527, 10.1016/j.mehy.2004.08.033

Meldrum, 2003, Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis, Circ. Res., 92, 293, 10.1161/01.RES.0000057754.35180.99

Park, 2001, Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase, EMBO J, 20, 446, 10.1093/emboj/20.3.446

Bruce, 2003, Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism, Diabetes, 52, 2338, 10.2337/diabetes.52.9.2338

Kurucz, 2002, Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance, Diabetes, 51, 1102, 10.2337/diabetes.51.4.1102

Chung, 2008, HSP72 protects against obesity-induced insulin resistance, Proc. Natl. Acad. Sci. USA, 105, 1739, 10.1073/pnas.0705799105

Gupte, 2009, Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats, J. Appl. Physiol, 106, 1425, 10.1152/japplphysiol.91210.2008

Putics, 2008, Resveratrol induces the heat-shock response and protects human cells from severe heat stress, Antioxid. Redox. Signal, 10, 65, 10.1089/ars.2007.1866

Yan, 2004, Paeoniflorin, a novel heat shock protein-inducing compound, Cell Stress Chaperones, 9, 378, 10.1379/CSC-51R.1

Aebi, 1984, Catalase in vitro, Methods Enzymol, 105, 121, 10.1016/S0076-6879(84)05016-3