Human papillomavirus infection and anal dysplasia in renal transplant recipients

British Journal of Surgery - Tập 97 Số 11 - Trang 1716-1721 - 2010
Heena Patel1, Andrew Silver1, Tanya Levine2, Greg Williams2, John Northover3
1Colorectal Cancer Genetics Group, Institute for Cell and Molecular Sciences, Barts and the London School of Medicine and Dentistry, London, UK
2Department of Pathology, North West London Hospitals NHS Trust, Harrow, UK
3St Mark's Hospital for Intestinal and Colorectal Disorders, North West London Hospitals NHS Trust, Harrow, UK

Tóm tắt

Abstract Background Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma. Additional risk factors for HPV-related disease have not been studied in the renal transplant population. The demographics of anal HPV and associated risk factors were investigated in this population. Methods Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital. Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease. Results Anal dysplasia was associated with anal oncogenic HPV infection (P < 0·001), duration of immunosuppression (P = 0·050), previous genital warts (P = 0·018) and receptive anal intercourse (P = 0·013). Conclusion Anal dysplasia was related to immunosuppression and patient factors in this cohort.

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Thông tin xuất bản

British Journal of Surgery

Tập 97 Số 11

1716-1721

Thông tin tác giả