The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

American Association for the Advancement of Science (AAAS) - Tập 11 Số 499 - 2019
Katrin Mestermann1, Theodoros Giavridis2, Justus Weber1, Julian Rydzek1, Silke Frenz1, Thomas Nerreter1, Andreas Mades1, Michel Sadelain2, Hermann Einsele1, Michael Hudecek1
1Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany
2Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Tóm tắt

Dasatinib is a pharmacologic switch for CARs that enables physicians to control CAR T cell function in real time.

Từ khóa


Tài liệu tham khảo

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American Association for the Advancement of Science (AAAS)

Tập 11 Số 499

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