Successful treatment of severe myasthenia gravis developed after allogeneic hematopoietic stem cell transplantation with plasma exchange and rituximab

Pediatric Blood and Cancer - Tập 61 Số 5 - Trang 928-930 - 2014
Şule Ünal1, Erdal Sağ2, Barış Kuşkonmaz1, Selman Kesici3, Benan Bayrakçı3, Deniz Çağdaş4, İlhan Tezcan4, Dilek Yalnızoğlu5, Duygu Uçkan1
1Division of Pediatric Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
2Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
3Division of Pediatric Intensive Care; Faculty of Medicine; Hacettepe University; Ankara Turkey
4Division of Pediatric Immunology; Faculty of Medicine; Hacettepe University; Ankara Turkey
5Division of Pediatric Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Tóm tắt

AbstractMyasthenia gravis is among the rare complications after allogeneic hematopoietic stem cell transplantation and is usually associated with chronic GVHD. Herein, we report a 2‐year and 10 months of age female with Griscelli syndrome, who developed severe myasthenia gravis at post‐transplant +22nd month and required respiratory support with mechanical ventilation. She was unresponsive to cyclosporine A, methylprednisolone, intravenous immunoglobulin, and mycophenolate mofetil and the symptoms could only be controlled after plasma exchange and subsequent use of rituximab, in addition to cyclosporine A and mycophenolate mofetil maintenance. She is currently asymptomatic on the 6th month of follow‐up. Pediatr Blood Cancer 2014;61:928–930. © 2013 Wiley Periodicals, Inc.

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Tài liệu tham khảo

10.1093/brain/awq245

10.1038/sj.bmt.1701575

Shimoda K, 1994, Myasthenia gravis after allogeneic bone marrow transplantation, Bone Marrow Transplant, 14, 155

Zaja F, 1995, Myasthenia gravis after allogeneic bone marrow transplantation: A case report, Bone Marrow Transplant, 15, 649

10.1038/sj.bmt.1701297

10.1002/pbc.21039

10.1016/j.bbmt.2006.10.020

10.2302/kjm.57.177

10.1182/blood-2008-10-161638

10.3109/10428190903586318

10.1056/NEJM198707163170314

10.1159/000116395

10.1038/sj.bmt.1700679

10.1038/sj.bmt.1701575

10.1212/WNL.36.8.1087

10.1016/0887-8994(94)00097-L

Gajdos P, 2002, Plasma exchange for myasthenia gravis, Cochrane Database Syst Rev, 4, CD002275

10.1111/j.1468-1331.2008.02399.x

10.1038/sj.bmt.1705725

10.1002/mus.23944

Thông tin
Thông tin xuất bản

Pediatric Blood and Cancer

Tập 61 Số 5

928-930

Thông tin tác giả