Conservation and diversification of MHC class I and its related molecules in vertebrates

Immunological Reviews - Tập 167 Số 1 - Trang 81-100 - 1999
Keiichiro Hashimoto1, Kazuhiko Okamura2, Hisateru Yamaguchi3, Mitsuru Ototake4, Teruyuki Nakanishi4, Yoshikazu Kurosaiva2
1Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan. [email protected]
2Fujita Health University
3医高分子学
4Fisheries Research Agency

Tóm tắt

Summary: The elucidation of the complete peptide‐binding domains of the highly polymorphic shark MHC class I genes offered us an opportunity to examine the characteristics of their predicted protein products in the light of the latest advance m the structural studies of the MHC class I molecules. The results suggest that the fundamental characteristics in the T‐cell recognition of the MHC class I molecule/peptide complex are expected to have been established at the early stage of the vertebrate evolution. The elucidation of the typical classical class I molecules from fishes and also of some MHC class I‐related molecules may help us Co explore the common denominator of the ancient class I molecules.

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