Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy

Blood - Tập 128 Số 8 - Trang 1112-1120 - 2016
Vindi Jurinović1,2, Robert Kridel3, Annette M. Staiger4,5, Monika Szczepanowski6, Heike Horn4,5, Martin Dreyling2, Andreas Rosenwald7, German Ott4, Wolfram Klapper6, Andrew D. Zelenetz8, Paul M. Barr9, Jonathan W. Friedberg9, Stephen M. Ansell10, Laurie H. Sehn3, Joseph M. Connors3, Randy D. Gascoyne3, Wolfgang Hiddemann11,2, Michael Unterhalt2, David M. Weinstock12, Oliver Weigert11,2
1Institute for Medical Informatics, Biometry, and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany
2Medical Department III, University Hospital of the Ludwig Maximilians University Munich, Munich, Germany;
3Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
4Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany
5Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany;
6Hematopathology Section, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;
7Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany;
8Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Medical College of Cornell University, New York, NY;
9Wilmot Cancer Institute, University of Rochester, Rochester, NY
10Division of Hematology, Mayo Clinic, Rochester, MN
11German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany; and
12Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Tóm tắt

Key Points The posttreatment end point progression of FL within 24 months (POD24) is strongly associated with OS. A pretreatment clinicogenetic risk model (m7-FLIPI) predicts POD24 and OS and identifies the smallest subgroup with highest unmet need.

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Tài liệu tham khảo

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