Obstacles and opportunities for understanding macrophage polarization

Martinez, 2008, Macrophage activation and polarization, Front. Biosci., 13, 453, 10.2741/2692

Gordon, 2003, Alternative activation of macrophages, Nat. Rev. Immunol., 3, 23, 10.1038/nri978

Gordon, 2010, Alternative activation of macrophages: mechanism and functions, Immunity, 32, 593, 10.1016/j.immuni.2010.05.007

Hume, 2008, Macrophages as APC and the dendritic cell myth, J. Immunol., 181, 5829, 10.4049/jimmunol.181.9.5829

Mantovani, 2008, Cancer-related inflammation, Nature, 454, 436, 10.1038/nature07205

Mantovani, 2010, Macrophages, innate immunity and cancer: balance, tolerance, and diversity, Curr. Opin. Immunol., 22, 231, 10.1016/j.coi.2010.01.009

Martinez, 2009, Alternative activation of macrophages: an immunologic functional perspective, Annu. Rev. Immunol., 27, 451, 10.1146/annurev.immunol.021908.132532

Mosser, 2008, Exploring the full spectrum of macrophage activation, Nat. Rev. Immunol., 8, 958, 10.1038/nri2448

Balkwill, 2004, Cancer: an inflammatory link, Nature, 431, 405, 10.1038/431405a

Condeelis, 2006, Macrophages: obligate partners for tumor cell migration, invasion, and metastasis, Cell, 124, 263, 10.1016/j.cell.2006.01.007

Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322

Qian, 2010, Macrophage diversity enhances tumor progression and metastasis, Cell, 141, 39, 10.1016/j.cell.2010.03.014

Joyce, 2009, Microenvironmental regulation of metastasis, Nat. Rev. Cancer, 9, 239, 10.1038/nrc2618

Biswas, 2010, Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm, Nat. Immunol., 11, 889, 10.1038/ni.1937

Biswas, 2008, Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms, J. Immunol., 180, 2011, 10.4049/jimmunol.180.4.2011

Goerdt, 1999, Other functions, other genes: alternative activation of antigen-presenting cells, Immunity, 10, 137, 10.1016/S1074-7613(00)80014-X

Gratchev, 2006, Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals, Immunobiology, 211, 473, 10.1016/j.imbio.2006.05.017

Stout, 2005, Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences, J. Immunol., 175, 342, 10.4049/jimmunol.175.1.342

Stout, 2004, Functional plasticity of macrophages: reversible adaptation to changing microenvironments, J. Lukoc. Biol., 76, 509, 10.1189/jlb.0504272

Stout, 2009, Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages, J. Leukoc. Biol., 86, 1105, 10.1189/jlb.0209073

Modolell, 1995, Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines, Eur. J. Immunol., 25, 1101, 10.1002/eji.1830250436

Mylonas, 2009, Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing, J. Immunol., 182, 3084, 10.4049/jimmunol.0803463

Rutschman, 2001, Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production, J. Immunol., 166, 2173, 10.4049/jimmunol.166.4.2173

Wells, 2003, Genetic control of the innate immune response, BMC Immunol., 4, 5, 10.1186/1471-2172-4-5

Mills, 2000, M-1/M-2 macrophages and the Th1/Th2 paradigm, J. Immunol., 164, 6166, 10.4049/jimmunol.164.12.6166

Way, 2009, The generation and properties of human macrophage populations from hemopoietic stem cells, J. Leukoc. Biol., 85, 766, 10.1189/jlb.1108689

El Kasmi, 2006, General nature of the STAT3-activated anti-inflammatory response, J. Immunol., 177, 7880, 10.4049/jimmunol.177.11.7880

Lang, 2002, Shaping gene expression in activated and resting primary macrophages by IL-10, J. Immunol., 169, 2253, 10.4049/jimmunol.169.5.2253

Lang, 2003, SOCS3 regulates the plasticity of gp130 signaling, Nat. Immunol., 4, 546, 10.1038/ni932

Ovchinnikov, 2010, A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice, J. Leukoc. Biol., 87, 815, 10.1189/jlb.0809557

Schneemann, 2007, Macrophage biology and immunology: man is not a mouse, J. Leukoc. Biol., 81, 579, 10.1189/jlb.1106702

Schneemann, 2002, Species differences in macrophage NO production are important, Nat. Immunol., 3, 102, 10.1038/ni0202-102a

Bogdan, 2001, Nitric oxide and the immune response, Nat. Immunol., 2, 907, 10.1038/ni1001-907

Fang, 2007, Man is not a mouse: reply, J. Leukoc. Biol., 81, 580, 10.1189/jlb.1206715

Nathan, 2006, Role of iNOS in human host defense, Science, 312, 1874, 10.1126/science.312.5782.1874b

Choi, 2002, Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis, Am. J. Respir. Crit. Care Med., 166, 178, 10.1164/rccm.2201023

Munder, 2009, Arginase: an emerging key player in the mammalian immune system, Br. J. Pharmacol., 158, 638, 10.1111/j.1476-5381.2009.00291.x

Munder, 2005, Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity, Blood, 105, 2549, 10.1182/blood-2004-07-2521

Munder, 2006, Suppression of T-cell functions by human granulocyte arginase, Blood, 108, 1627, 10.1182/blood-2006-11-010389

Raes, 2005, Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells, J. Immunol., 174, 6561, 10.4049/jimmunol.174.11.6561

Coers, 2009, Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNγ responses, PLoS Pathog., 5, e1000333, 10.1371/journal.ppat.1000333

Hargreaves, 2009, Control of inducible gene expression by signal-dependent transcriptional elongation, Cell, 138, 129, 10.1016/j.cell.2009.05.047

Medzhitov, 2009, Transcriptional control of the inflammatory response, Nat. Rev. Immunol., 9, 692, 10.1038/nri2634

Ramirez-Carrozzi, 2009, A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling, Cell, 138, 114, 10.1016/j.cell.2009.04.020

Saraiva, 2010, The regulation of IL-10 production by immune cells, Nat. Rev. Immunol., 10, 170, 10.1038/nri2711

Loke, 2002, IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype, BMC Immunol., 3, 7, 10.1186/1471-2172-3-7

Nair, 2003, Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro, Immunol. Lett., 85, 173, 10.1016/S0165-2478(02)00225-0

Zimmermann, 2003, Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis, J. Clin. Invest., 111, 1863, 10.1172/JCI17912

Siracusa, 2008, Dynamics of lung macrophage activation in response to helminth infection, J. Leukoc. Biol., 84, 1422, 10.1189/jlb.0308199

Zhang, 2010, Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines, PLoS Negl. Trop. Dis., 4, e648, 10.1371/journal.pntd.0000648

Sandler, 2003, Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair, J. Immunol., 171, 3655, 10.4049/jimmunol.171.7.3655

Stütz, 2003, The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule α gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism, J. Immunol., 170, 1789, 10.4049/jimmunol.170.4.1789

Herbert, 2004, Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology, Immunity, 20, 623, 10.1016/S1074-7613(04)00107-4

Albina, 2005, Macrophage arginase regulation by CCAAT/enhancer-binding protein β, Shock, 23, 168, 10.1097/01.shk.0000148054.74268.e2

El Kasmi, 2008, Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens, Nat. Immunol., 9, 1399, 10.1038/ni.1671

Gray, 2005, Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ, Gene, 353, 98, 10.1016/j.gene.2005.04.004

Munder, 1999, Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells, J. Immunol., 163, 3771, 10.4049/jimmunol.163.7.3771

Pauleau, 2004, Enhancer-mediated control of macrophage-specific arginase I expression, J. Immunol., 172, 7565, 10.4049/jimmunol.172.12.7565

Herbert, 2010, Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis, J. Immunol., 184, 6438, 10.4049/jimmunol.0902009

Corraliza, 1995, Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages, Biochem. Biophys. Res. Commun., 206, 667, 10.1006/bbrc.1995.1094

Mori, 1998, Regulation of the urea cycle enzyme genes in nitric oxide synthesis, J. Inherit. Metab. Dis., 21, 59, 10.1023/A:1005357608129

Qualls, 2010, Sci. Signal.

Saeij, 2007, Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue, Nature, 445, 324, 10.1038/nature05395

Pesce, 2009, Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis, PLoS Pathog., 5, e1000371, 10.1371/journal.ppat.1000371

Liu, 2004, FIZZ1 stimulation of myofibroblast differentiation, Am. J. Pathol., 164, 1315, 10.1016/S0002-9440(10)63218-X

Li, 2005, Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy, Am. J. Respir. Cell Mol. Biol., 32, 185, 10.1165/rcmb.2004-0325OC

Pesce, 2009, Retnla (relmα/fizz1) suppresses helminth-induced Th2-type immunity, PLoS Pathog., 5, e1000393, 10.1371/journal.ppat.1000393

Nair, 2009, Alternatively activated macrophage-derived RELM-{α} is a negative regulator of type 2 inflammation in the lung, J. Exp. Med., 206, 937, 10.1084/jem.20082048

Burnett, 2006, Development of peritoneal adhesions in macrophage depleted mice, J. Surg. Res., 131, 296, 10.1016/j.jss.2005.08.026

Saxena, 2007, The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse, J. Immunol., 179, 5041, 10.4049/jimmunol.179.8.5041

Dai, 2002, Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects, Blood, 99, 111, 10.1182/blood.V99.1.111

MacDonald, 2010, An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation, Blood, 116, 3955, 10.1182/blood-2010-02-266296

Clausen, 1999, Conditional gene targeting in macrophages and granulocytes using LysMcre mice, Transgenic Res., 8, 265, 10.1023/A:1008942828960

Takeda, 1999, Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils, Immunity, 10, 39, 10.1016/S1074-7613(00)80005-9

Bell, 2008, The earliest thymic progenitors for T cells possess myeloid lineage potential, Nature, 452, 764, 10.1038/nature06840

Faust, 2000, Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages, Blood, 96, 719, 10.1182/blood.V96.2.719.014k29_719_726

Ye, 2003, Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential, Immunity, 19, 689, 10.1016/S1074-7613(03)00299-1

Kisanuki, 2001, Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo, Dev. Biol., 230, 230, 10.1006/dbio.2000.0106