Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu

Nature Medicine - Tập 14 Số 6 - Trang 641-647 - 2008
Vasundhara Varthakavi1, Ellen Heimann-Nichols1, Rita M. Smith1, Yuehui Sun1, Richard J. Bram2, Showkat Ali3, Jeremy J. Rose3, Lingmei Ding3, Paul Spearman4
1Department of Pediatrics, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, USA
2Department of Pediatric and Adolescent Medicine, Division of Pediatric Research Laboratories, Mayo Clinic, Mayo Medical School, 200 First Street Southwest, Rochester, 55905, Minnesota, USA
3Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, USA
4Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, 2015 Upper Gate Drive, Atlanta, 30322, Georgia, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Strebel, K., Klimkait, T. & Martin, M.A. A novel gene of HIV-1, vpu, and its 16-kilodalton product. Science 241, 1221–1223 (1988).

Maldarelli, F., Chen, M.Y., Willey, R.L. & Strebel, K. Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein. J. Virol. 67, 5056–5061 (1993).

Willey, R.L., Maldarelli, F., Martin, M.A. & Strebel, K. Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4. J. Virol. 66, 7193–7200 (1992).

Terwilliger, E.F., Cohen, E.A., Lu, Y.C., Sodroski, J.G. & Haseltine, W.A. Functional role of human immunodeficiency virus type 1 vpu. Proc. Natl. Acad. Sci. USA 86, 5163–5167 (1989).

Margottin, F. et al. A novel human WD protein, h-β TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol. Cell 1, 565–574 (1998).

Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263–274 (1996).

Schubert, U., Clouse, K.A. & Strebel, K. Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes. J. Virol. 69, 7699–7711 (1995).

Klimkait, T., Strebel, K., Hoggan, M.D., Martin, M.A. & Orenstein, J.M. The human immunodeficiency virus type 1–specific protein vpu is required for efficient virus maturation and release. J. Virol. 64, 621–629 (1990).

Schwartz, M.D., Geraghty, R.J. & Panganiban, A.T. HIV-1 particle release mediated by Vpu is distinct from that mediated by p6. Virology 224, 302–309 (1996).

Varthakavi, V., Smith, R.M., Bour, S.P., Strebel, K. & Spearman, P. Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production. Proc. Natl. Acad. Sci. USA 100, 15154–15159 (2003).

Abada, P., Noble, B. & Cannon, P.M. Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production. J. Virol. 79, 3627–3638 (2005).

Gottlinger, H.G., Dorfman, T., Cohen, E.A. & Haseltine, W.A. Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses. Proc. Natl. Acad. Sci. USA 90, 7381–7385 (1993).

Bour, S. & Strebel, K. The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses. J. Virol. 70, 8285–8300 (1996).

Varthakavi, V. et al. The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release. Traffic 7, 298–307 (2006).

Bram, R.J. & Crabtree, G.R. Calcium signalling in T cells stimulated by a cyclophilin B–binding protein. Nature 371, 355–358 (1994).

Tran, D.D. et al. CAML is a p56Lck-interacting protein that is required for thymocyte development. Immunity 23, 139–152 (2005).

Tran, D.D., Russell, H.R., Sutor, S.L., van Deursen, J. & Bram, R.J. CAML is required for efficient EGF receptor recycling. Dev. Cell 5, 245–256 (2003).

Neil, S.J., Eastman, S.W., Jouvenet, N. & Bieniasz, P.D. HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane. PLoS Pathog. 2, e39 (2006).

Callahan, M.A. et al. Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family. J. Virol. 72, 5189–5197 (1998).

Yao, X.J., Gottlinger, H., Haseltine, W.A. & Cohen, E.A. Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export. J. Virol. 66, 5119–5126 (1992).

Cervantes-Acosta, G., Cohen, E.A. & Lemay, G. Human Jurkat lymphocytes clones differ in their capacity to support productive human immunodeficiency virus type 1 multiplication. J. Virol. Methods 92, 207–213 (2001).

Garrus, J.E. et al. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107, 55–65 (2001).

Martin-Serrano, J., Zang, T. & Bieniasz, P.D. Role of ESCRT-I in retroviral budding. J. Virol. 77, 4794–4804 (2003).

Tanzi, G.O., Piefer, A.J. & Bates, P. Equine infectious anemia virus utilizes host vesicular protein sorting machinery during particle release. J. Virol. 77, 8440–8447 (2003).

Strack, B., Calistri, A., Craig, S., Popova, E. & Gottlinger, H.G. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 114, 689–699 (2003).

Neil, S.J., Zang, T. & Bieniasz, P.D. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451, 425–430 (2008).

Bartee, E., McCormack, A. & Fruh, K. Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog. 2, e107 (2006).

Feng, P. et al. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J. Virol. 76, 11491–11504 (2002).

Tovey, S.C., Bootman, M.D., Lipp, P., Berridge, M.J. & Bram, R.J. Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. Biochem. Biophys. Res. Commun. 276, 97–100 (2000).

Gomez, T.S. et al. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity 24, 741–752 (2006).

Smith, A.J., Cho, M.I., Hammarskjold, M.L. & Rekosh, D. Human immunodeficiency virus type 1 Pr55gag and Pr160gag-pol expressed from a simian virus 40 late replacement vector are efficiently processed and assembled into viruslike particles. J. Virol. 64, 2743–2750 (1990).

Wehrly, K. & Chesebro, B. p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagents. Methods 12, 288–293 (1997).