Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin

Springer Science and Business Media LLC - Tập 53 - Trang 1428-1432 - 2010
ShaoHui Chen1, Jing Zhao1, YuGuang Huang1, AiLun Luo1, PingPing Zuo2, Nan Yang2, WenYu Hao2
1Department of Anesthesia, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
2Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Tóm tắt

The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.

Tài liệu tham khảo

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