Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

International Journal of Cancer - Tập 53 Số 5 - Trang 781-784 - 1993
Hong‐Ji Xu1, Paul Cairns2, Shi‐Xue Hu1, Margaret A. Knowles2, William F. Benedict3
1Baylor college of Medicine;
2Marie Curie Research Institute
3Genitourinary Medical Oncology

Tóm tắt

AbstractRB‐protein status as determined by immunohistochemical analysis was compared with loss of heterozygosity (LOH) at the RB locus in 68 primary transitional‐cell carcinomas of the bladder. Absence of RB‐protein expression was found in 15 of 17 tumors in which LOH at the RB locus was identified, whereas 31 of 36 tumors from informative patients which showed no LOH had a normal RB‐protein pattern ( p < 0.001). Altered RB‐protein expression was also more frequently seen in muscle‐invasive and high‐grade tumors ( p < 0.003 and <0.005, respectively). Our results indicate that LOH at the RB locus is highly correlated with loss of RB‐protein expression in primary bladder carcinomas and further strengthens the notion that loss of RB function may be associated with more aggressive bladder tumors.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

International Journal of Cancer

Tập 53 Số 5

781-784

Thông tin tác giả