Self-antigen recognition by follicular lymphoma B-cell receptors

Summers, 2001, Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma., J Clin Oncol, 19, 420, 10.1200/JCO.2001.19.2.420 Schmitt, 2006, The bcl-2/IgH rearrangement in a population of 204 healthy individuals: occurrence, age and gender distribution, breakpoints, and detection method validity., Leuk Res, 30, 745, 10.1016/j.leukres.2005.10.001 Schüler, 2009, Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals., Int J Cancer, 124, 958, 10.1002/ijc.23958 de Jong, 2005, Molecular pathogenesis of follicular lymphoma: a cross talk of genetic and immunologic factors., J Clin Oncol, 23, 6358, 10.1200/JCO.2005.26.856 Bognár, 2005, Clonal selection in the bone marrow involvement of follicular lymphoma., Leukemia, 19, 1656, 10.1038/sj.leu.2403844 Cleary, 1986, Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B-cell lymphoma., Cell, 44, 97, 10.1016/0092-8674(86)90488-5 Gururajan, 2006, Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma., J Immunol, 176, 5715, 10.4049/jimmunol.176.10.5715 Monroe, 2006, ITAM-mediated tonic signalling through pre-BCR and BCR complexes., Nat Rev Immunol, 6, 283, 10.1038/nri1808 Jacobs, 2001, Towards an understanding of somatic hypermutation., Curr Opin Immunol, 13, 208, 10.1016/S0952-7915(00)00206-5 Bahler, 1992, Clonal evolution of a follicular lymphoma: evidence for antigen selection., Proc Natl Acad Sci U S A, 89, 6770, 10.1073/pnas.89.15.6770 Bahler, 1992, Antigen selection in human lymphomagenesis., Cancer Res, 52, 5547S Hershberg, 2008, Improved methods for detecting selection by mutation analysis of Ig V region sequences., Int Immunol, 20, 683, 10.1093/intimm/dxn026 Zuckerman, 2010, Ig gene diversification and selection in follicular lymphoma, diffuse large B-cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses., Int Immunol, 22, 875, 10.1093/intimm/dxq441 Quinn, 2001, The B-cell receptor of a hepatitis C virus (HCV)–associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis., Blood, 98, 3745, 10.1182/blood.V98.13.3745 Hermine, 2002, Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection., N Engl J Med, 347, 89, 10.1056/NEJMoa013376 Bende, 2005, Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity., J Exp Med, 201, 1229, 10.1084/jem.20050068 Craig, 2010, Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins., Blood, 115, 581, 10.1182/blood-2009-06-228015 Warsame, 2011, Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity., Blood, 118, 3331, 10.1182/blood-2011-03-341651 Darzentas, 2010, A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence., Leukemia, 24, 125, 10.1038/leu.2009.186 Hervé, 2005, Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity., J Clin Invest, 115, 1636, 10.1172/JCI24387 Chu, 2008, Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA., Blood, 112, 5122, 10.1182/blood-2008-06-162024 Noppe, 1999, The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism., Br J Haematol, 107, 625, 10.1046/j.1365-2141.1999.01732.x Dighiero, 1991, Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas., Blood, 78, 581, 10.1182/blood.V78.3.581.581 Timmerman, 2009, Tumor-specific recombinant idiotype immunisation after chemotherapy as initial treatment for follicular non-Hodgkin lymphoma., Leuk Lymphoma, 50, 37, 10.1080/10428190802563355 Levy, 2008, Results of a phase 3 trial evaluating safety and efficacy of specific immunotherapy, recombinant idiotype (Id) conjugated to KLH (Id-KLH) with GM-CSF, compared to non-specific immunotherapy, KLH with GM-CSF, in patients with follicular non-Hodgkin's lymphoma (fNHL) [abstract]., AACR Meeting Abstracts, LB-204 Campbell, 1992, Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire., Mol Immunol, 29, 193, 10.1016/0161-5890(92)90100-C Uduman, 2011, Detecting selection in immunoglobulin sequences., Nucleic Acids Res, 39, W499, 10.1093/nar/gkr413 Bernatchez, 2007, Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function., J Biol Chem, 282, 30745, 10.1074/jbc.M704798200 Lopez-Avila, 2006, Determination of ceruloplasmin in human serum by SEC-ICPMS., Anal Bioanal Chem, 386, 180, 10.1007/s00216-006-0528-9 Abdiche, 2008, Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet., Anal Biochem, 377, 209, 10.1016/j.ab.2008.03.035 Kotecha, 2010, Web-based analysis and publication of flow cytometry experiments., Curr Protoc Cytom, 10.1002/0471142956.cy1017s53 Egner, 2000, The use of laboratory tests in the diagnosis of SLE., J Clin Pathol, 53, 424, 10.1136/jcp.53.6.424 Tiller, 2007, Autoreactivity in human IgG+ memory B cells., Immunity, 26, 205, 10.1016/j.immuni.2007.01.009 Tsuiji, 2006, A checkpoint for autoreactivity in human IgM+ memory B cell development., J Exp Med, 203, 393, 10.1084/jem.20052033 Zhu, 2002, Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma., Blood, 99, 2562, 10.1182/blood.V99.7.2562 Radcliffe, 2007, Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor., J Biol Chem, 282, 7405, 10.1074/jbc.M602690200 Martin, 2002, Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas., Nature, 415, 802, 10.1038/nature714 Irish, 2006, Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells., Blood, 108, 3135, 10.1182/blood-2006-02-003921 Dameshek, 1959, Leukemia and auto-immunization: some possible relationships., Blood, 14, 1151, 10.1182/blood.V14.10.1151.1151 Zuckerman, 2010, Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases., J Autoimmun, 35, 325, 10.1016/j.jaut.2010.07.004 Zuckerman, 2010, Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC., Eur J Immunol, 40, 1150, 10.1002/eji.200939914 Willenbrock, 2006, Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin's lymphoma., Haematologica, 91, 596 Yurasov, 2005, Defective B cell tolerance checkpoints in systemic lupus erythematosus., J Exp Med, 201, 703, 10.1084/jem.20042251 Meffre, 1998, Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells., J Exp Med, 188, 765, 10.1084/jem.188.4.765 Raffeld, 1987, Clonal evolution of t(14;18) follicular lymphomas demonstrated by immunoglobulin genes and the 18q21 major breakpoint region., Cancer Res, 47, 2537 Stiernholm, 1994, Immunoglobulin somatic variation: studies of receptor editing in a human B-cell lymphoma., Leuk Lymphoma, 12, 333, 10.3109/10428199409073774 Roux, 2007, RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation., J Biol Chem, 282, 14056, 10.1074/jbc.M700906200 Coelho, 2010, Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins., Proc Natl Acad Sci U S A, 107, 18587, 10.1073/pnas.1009388107 Cheson, 2011, New agents in follicular lymphoma., Best Pract Res Clin Haematol, 24, 305, 10.1016/j.beha.2011.03.006 Sawas, 2011, New therapeutic targets and drugs in non-Hodgkin's lymphoma., Curr Opin Hematol, 18, 280