Hepatocellular carcinoma metastasis in the pituitary gland: case report and review of the literature

Journal of Neuro-Oncology - Tập 63 Số 2 - Trang 173-177 - 2003
Karamouzis, M.V.1, Melachrinou, M.2, Fratzoglou, M.3, Labropoulou-Karatza, Ch.4, Kalofonos, H.P.1
1Division of Oncology, Department of Medicine, University Hospital of Patras, Rion, Greece
2Department of Pathology, University Hospital of Patras, Rion, Greece
3Department of Neurosurgery, University Hospital of Patras, Rion, Greece
4Department of Internal Medicine, University Hospital of Patras, Rion, Greece

Tóm tắt

Symptomatic pituitary metastases are uncommon and have been reported mainly in autopsy series. Although all types of malignancies can metastasize to the pituitary gland, a review of the literature has indicated that lung and breast carcinomas are the most frequent primary tumors while hepatocellular carcinoma metastasis has only recently been described. A 59-year-old man with abdominal pain and fever was admitted to our hospital. Hepatosplenomegaly was present without signs of ascites. Laboratory tests showed only abnormal hepatic biochemistry while the radiological studies revealed a solid mass occupying the left hepatic lobe. The patient underwent excision of the left hepatic lobe and was closely followed-up. Six months later he readmitted with headache and visual disturbances. MRI revealed a solid mass in the sella region pressing the optic chiasma. Transsphenoidal excision of the pituitary mass was followed and the histological examination of the tumor was compatible with hepatocellular carcinoma. Symptomatic pituitary metastases are uncommon and may be difficult to differentiate from pituitary adenomas. The present case emphasizes on the capricious nature of hepatocellular carcinoma and on the importance of the individualized therapeutic approach.

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citation_journal_title=Ann Surg Oncol; citation_title=Pituitary gland metastases; citation_author=P Sioutos, V Yen, E Arbit; citation_volume=3; citation_publication_date=1996; citation_pages=94-99; citation_id=CR1

citation_journal_title=Oncology; citation_title=Metastatic cancer of the pituitary gland; citation_author=K Kovacs; citation_volume=27; citation_publication_date=1972; citation_pages=533-542; citation_id=CR2

citation_journal_title=Cancer; citation_title=Metastatic lesions in the sella turcica and pituitary gland; citation_author=U Roessman, B Kaufman, RL Friede; citation_volume=25; citation_publication_date=1970; citation_pages=478-480; citation_id=CR3

citation_journal_title=Cancer; citation_title=Clinicopathologic review of 88 cases of carcinoma metastatic to the pituitary gland; citation_author=R Teears, EM Silverman; citation_volume=36; citation_publication_date=1975; citation_pages=216-220; citation_id=CR4

citation_journal_title=Neurology; citation_title=Pituitary metastasis: incidence in cancer patients and clinical differentiation from pituitary adenoma; citation_author=MB Max, DF Deck, DA Rottenberg; citation_volume=31; citation_publication_date=1981; citation_pages=998-1002; citation_id=CR5

citation_journal_title=Br J Neurosurg; citation_title=Metastatic carcinoma to the pituitary gland; citation_author=PC McCormick, KD Post, AD Kandji, AP Hays; citation_volume=3; citation_publication_date=1989; citation_pages=71-80; citation_id=CR6

citation_journal_title=J Neurosurg; citation_title=Symptomatic pituitary metastases; citation_author=A Morita, FB Meyer, ER Laws; citation_volume=89; citation_publication_date=1998; citation_pages=69-73; citation_id=CR7

citation_journal_title=Surg Neurol; citation_title=Chiasmal compression from metastatic cancer to the pituitary gland; citation_author=EV Cox; citation_volume=11; citation_publication_date=1979; citation_pages=49-50; citation_id=CR8

citation_journal_title=Surg Neurol; citation_title=Intrasellar metastasis mimicking a pituitary adenoma; citation_author=R Buonaguidi, M Ferdeghini, F Faggionato, G Tusini; citation_volume=20; citation_publication_date=1983; citation_pages=373-378; citation_id=CR9

citation_journal_title=Neurosurgery; citation_title=Metastatic tumor of the pituitary gland; citation_author=PB Nelson, AG Robinson, AJ Martinez; citation_volume=21; citation_publication_date=1987; citation_pages=941-944; citation_id=CR10

citation_journal_title=J Clin Pathol; citation_title=Bronchioloalveolar carcinoma with metastasis to the pituitary gland: a case report; citation_author=G Lan, SY Tan, G Chiang, WT Poh; citation_volume=51; citation_publication_date=1998; citation_pages=931-934; citation_id=CR11

citation_journal_title=Cancer; citation_title=Clinical features of tumor metastasis to the pituitary; citation_author=WA Houck, KB Olson, J Horton; citation_volume=26; citation_publication_date=1970; citation_pages=656-659; citation_id=CR12

citation_journal_title=J Clin Endocrinol Metab; citation_title=Metastatic tumors of the sella turcica masqueding as primary pituitary tumors; citation_author=CL Branch, ER Laws; citation_volume=65; citation_publication_date=1987; citation_pages=469-474; citation_id=CR13

citation_journal_title=Cancer; citation_title=Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma; citation_author=XD Zhou, ZY Tang, BH Yang, ZY Lin, ZC Ma, SL Ye, ZQ Wu, J Fan, LX Qin, BH Zheng; citation_volume=91; citation_publication_date=2001; citation_pages=1479-1486; citation_id=CR14

citation_journal_title=Br J Cancer; citation_title=Hepatocellular carcinoma; citation_author=M Giovannini, D Elias, G Monges, JL Raoul, P Rougier; citation_volume=84; citation_publication_date=2001; citation_pages=74-77; citation_id=CR15

citation_journal_title=Eur J Gastroenterol Hepatol; citation_title=Does the choice of treatment influence survival of patients with small hepatocellular carcinoma in compensated cirrhosis?; citation_author=F Farinati, S Gianni, G Marin, S Fagiuoli, M Rinaldi, R Naccarato; citation_volume=13; citation_publication_date=2001; citation_pages=1217-1224; citation_id=CR16

citation_journal_title=Eur J Gastroenterol Hepatol; citation_title=The clinical features and prognostic factors of hepatocellular carcinoma patients with spinal metastasis; citation_author=SS Chang, JC Luo, Y Chao, JY Chao, KH Chi, SS Wang, FY Chang, SD Lee, SH Yen; citation_volume=13; citation_publication_date=2001; citation_pages=1341-1345; citation_id=CR17

citation_journal_title=Surg Neurol; citation_title=Hepatocellular carcinoma presenting as intracranial metastasis; citation_author=JP Lee, ST Lee; citation_volume=4; citation_publication_date=1988; citation_pages=316-320; citation_id=CR18

citation_journal_title=Ann Oncol; citation_title=Hepatocellular carcinoma; citation_author=SA Hussain, DR Ferry, G El-Gazzaz, DF Mirza, ND James, P McMaster, DJ Kerr; citation_volume=12; citation_publication_date=2001; citation_pages=161-172; citation_id=CR19

citation_journal_title=J Gastroenterol Hepatol; citation_title=Clinical and radiological pictures of hepatocellular carcinoma with intracranial metastasis; citation_author=FS Yen, JC Wu, CR Lai, WY Sheng, BI Kuo, TZ Chen; citation_volume=10; citation_publication_date=1995; citation_pages=413-418; citation_id=CR20

citation_journal_title=Radiology; citation_title=Extrahepatic metastases of hepatocellular carcinoma; citation_author=S Katyal, JH Oliver, MS Peterson, JV Ferris, BS Carr, RL Baron; citation_volume=216; citation_publication_date=2000; citation_pages=698-703; citation_id=CR21

citation_journal_title=Hong Kong Med J; citation_title=Hepatocellular carcinoma with metastasis to the skull base, pituitary gland, sphenoid sinus, and cavernous sinus; citation_author=TH Aung, YC Po, WK Wong; citation_volume=8; citation_publication_date=2002; citation_pages=48-51; citation_id=CR22

citation_journal_title=Neurochirurgia; citation_title=Pituitary metastases; citation_author=MF Chiang, M Broch, S Patt; citation_volume=33; citation_publication_date=1990; citation_pages=127-131; citation_id=CR23

citation_journal_title=Neuroradiology; citation_title=Metastasis to the pituitary- hypothalamic axis; citation_author=O Schubiger, D Haller; citation_volume=34; citation_publication_date=1992; citation_pages=131-134; citation_id=CR24

citation_journal_title=Cancer; citation_title=Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies; citation_author=HA Edmonson, PE Steiner; citation_volume=7; citation_publication_date=1954; citation_pages=462-503; citation_id=CR25

citation_journal_title=Cancer; citation_title=Pathology of hepatocellular carcinoma in Japan: 232 consecutive cases of autopsies in ten years; citation_author=T Nakashima, K Okuda, M Kojiro, A Jimi, R Yamaguchi, K Sakamoto, T Ikari; citation_volume=51; citation_publication_date=1983; citation_pages=863-877; citation_id=CR26

citation_journal_title=Mayo Clin Proc; citation_title=The pituitary gland in patients with breast carcinoma: a histologic and immunocytochemical study of 125 cases; citation_author=F Martin, KT Kovacs, BW Scheithauer, WF Young; citation_volume=67; citation_publication_date=1992; citation_pages=949-956; citation_id=CR27

citation_journal_title=Ann Oncol; citation_title=Hepatocellular carcinoma after long-term tamoxifen therapy; citation_author=DF Moffat, KA Oien, J Dickson, T Habeshaw, DR McLellan; citation_volume=11; citation_publication_date=2000; citation_pages=1195-1196; citation_id=CR28

citation_journal_title=J Clin Oncol; citation_title=Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: a study of a prospective cohort; citation_author=RT Poon, IO Ng, ST Fan, EC Lai, CM Lo, CL Liu, J Wong; citation_volume=19; citation_publication_date=2001; citation_pages=3037-3044; citation_id=CR29

citation_journal_title=Cancer; citation_title=Is the pathologic TNM staging system for patients with hepatoma predictive of outcome?; citation_author=JW Marsh, I Dvorchik, CA Bonham, S Iwatsuki; citation_volume=88; citation_publication_date=2000; citation_pages=538-543; citation_id=CR30

citation_journal_title=Eur J Gastroenterol Hepatol; citation_title=Increased incidence of bone metastasis in hepatocellular carcinoma; citation_author=M Fukutomi, M Yokota, H Chuman, H Harada, Y Zaitsu, A Funakoshi, H Wakasugi, H Iguchi; citation_volume=13; citation_publication_date=2001; citation_pages=1083-1088; citation_id=CR31

citation_journal_title=Cancer; citation_title=Is preoperative portal vein thromboembolization effective in improving prognosis after major hepatic resection in patients with advanced-stage hepatocellular carcinoma?; citation_author=H Wakabayashi, K Ishimura, K Okano, K Izuishi, Y Karasawa, F Goda, T Maeba, H Maeta; citation_volume=92; citation_publication_date=2001; citation_pages=2384-2390; citation_id=CR32

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Journal of Neuro-Oncology

Tập 63 Số 2

173-177

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