Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport

Molecular Microbiology - Tập 11 Số 5 - Trang 841-847 - 1994
Milton H. Saier1, Roland Tam1, Aiala Reizer1, Jonathan Reizer1
1Department of Biology, University of California at San Diego, La Jolla, California 92093-0116, USA

Tóm tắt

Summary

Homology has been established for members of two families of functionally related bacterial membrane proteins. The first family (the resistance/nodulation/cell division (RND) family) Includes (i) two metal‐resistance efflux pumps in Alcaligenes eutrophus (CzcA and CnrA), (ii) three proteins which function together in nodulation of alfalfa roots by Rhizobium meliloti (NoIGHI), and (iii) a cell division protein in Escherichia coli (EnvD). The second family (the putative membrane fusion protein (MFP) family) includes a nodulation protein (NoIF), a cell division protein (EnvC), and a multidrug resistance transport protein (EmrA). We propose that an MFP functions co‐operatively with an RND protein to transport large or hydrophobic molecules across the two membranes of the Gram‐negative bacterial cell envelope.

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Thông tin xuất bản

Molecular Microbiology

Tập 11 Số 5

841-847

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