CMV and Immunosenescence: from basics to clinics

Immunity & Ageing - Tập 9 - Trang 1-9 - 2012
Rafael Solana1, Raquel Tarazona2, Allison E Aiello3, Arne N Akbar4, Victor Appay5, Mark Beswick6, Jos A Bosch7,8, Carmen Campos1, Sara Cantisán1, Luka Cicin-Sain9, Evelyna Derhovanessian10, Sara Ferrando-Martínez11, Daniela Frasca12, Tamas Fulöp13, Sheila Govind14, Beatrix Grubeck-Loebenstein15, Ann Hill16, Mikko Hurme17, Florian Kern18, Anis Larbi19, Miguel López-Botet20, Andrea B Maier21, Janet E McElhaney22, Paul Moss6, Elissaveta Naumova23, Janko Nikolich-Zugich24, Alejandra Pera1, Jerrald L Rector25, Natalie Riddell4, Beatriz Sanchez-Correa2, Paolo Sansoni26, Delphine Sauce5, Rene van Lier27, George C Wang28, Mark R Wills29, Maciej Zieliński30, Graham Pawelec10
1Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spain
2Immunology Unit, Department of Physiology, University of Extremadura, Caceres, Spain
3Department of Epidemiology, University of Michigan,Center for Social Epidemiology and Population Health, Ann Arbor, USA
4Division of Infection and Immunity, University College London, London, UK
5Infections and Immunity, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
6School of Cancer Sciences, University of Birmingham, Birmingham, UK
7University of Amsterdam, Amsterdam, The Netherlands
8Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), University of Heidelberg, Mannheim Medical Faculty, Mannheim, Germany
9Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
10Department of Internal Medicine II, Center for Medical Research University of Tübingen, Tübingen, Germany
11Laboratory of Molecular Immune-Biology, Hospital General Universitario Gregorio Marañón, Madrid and Laboratory of Immunovirology; Infectious Diseases Service, IBiS, Seville, Spain
12Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, USA
13Research Center on Aging, Sherbrooke, Canada
14Regenerative Medicine Group, Cranfield Health, Cranfield University, Cranfield, UK
15Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria
16Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, USA
17University of Tampere Medical School, Tampere, Finland
18Brighton and Sussex Medical School. Brighton, UK
19Singapore Immunology Network, Singapore, Singapore
20IMIM (Hospital del Mar Research Institute), Univ. Pompeu Fabra, Barcelona, Spain
21Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
22University of British Columbia, Vancouver, Canada
23Department of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria
24Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, USA
25University of Birmingham, Birmingham, UK
26Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
27Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
28Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, USA
29University of Cambridge Department of Medicine Addenbrookes Hospital, Cambridge, UK
30Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland

Tóm tắt

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

Tài liệu tham khảo

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