T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites

World Health Organization, 1998, The World Health Report 1998. Life in the 21st century: a vision for all. Mack, 1995, A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity., Proc Natl Acad Sci U S A., 92, 7021, 10.1073/pnas.92.15.7021 Loffler, 2000, A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes., Blood., 95, 2098, 10.1182/blood.V95.6.2098 Belani, 1995, T cell activation and cytokine production in anti-CD3 bispecific antibody therapy., J Hematother., 4, 395, 10.1089/scd.1.1995.4.395 George, 1994, Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule., J Immunol., 152, 1802, 10.4049/jimmunol.152.4.1802 Barth, 2000, Ki-4(scFv)-ETA′, a new recombinant anti-CD30 immunotoxin with highly specific cytotoxic activity against disseminated Hodgkin tumors in SCID mice., Blood., 95, 3909, 10.1182/blood.V95.12.3909 Tibben, 1996, Pharmacokinetics, biodistribution and biological effects of intravenously administered bispecific monoclonal antibody OC/TR F(ab′)2 in ovarian carcinoma patients., Int J Cancer., 66, 477, 10.1002/(SICI)1097-0215(19960516)66:4<477::AID-IJC11>3.0.CO;2-5 Canevari, 1995, Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecific monoclonal antibody., J Natl Cancer Inst., 87, 1463, 10.1093/jnci/87.19.1463 De Gast, 1995, CD8 T cell activation after intravenous administration of CD3 × CD19 bispecific antibody in patients with non-Hodgkin lymphoma., Cancer Immunol Immunother., 40, 390, 10.1007/BF01525390 Chamow, 1995, A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells., J Hematother., 4, 439, 10.1089/scd.1.1995.4.439 Traunecker, 1991, Bispecific single chain molecules (Janusins) target cytotoxic lymphocytes on HIV infected cells., EMBO J., 10, 3655, 10.1002/j.1460-2075.1991.tb04932.x Berg, 1991, Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain., Proc Natl Acad Sci U S A., 88, 4723, 10.1073/pnas.88.11.4723 Chappel, 1993, Monoclonal antibodies that inhibit Plasmodium falciparum invasion in vitro recognise the first growth factor-like domain of merozoite surface protein-1., Mol Biochem Parasitol., 60, 303, 10.1016/0166-6851(93)90141-J Kumar, 1995, Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-1 in Aotus monkeys., Mol Med., 1, 325, 10.1007/BF03401557 Hirunpetcharat, 1997, Complete protective immunity induced in mice by immunization with the 19-kilodalton carboxyl-terminal fragment of the merozoite surface protein-1 (MSP1[19]) of Plasmodium yoelii expressed in Saccharomyces cerevisiae: correlation of protection with antigen-specific antibody titer, but not with effector CD4+ T cells., J Immunol., 159, 3400, 10.4049/jimmunol.159.7.3400 Keitel, 1999, Phase I trial of two recombinant vaccines containing the 19kd carboxy terminal fragment of Plasmodium falciparum merozoite surface protein 1 (msp-1(19)) and T helper epitopes of tetanus toxoid., Vaccine., 18, 531, 10.1016/S0264-410X(99)00221-2 Yoshida, 1999, A single-chain antibody fragment specific for the Plasmodium berghei ookinete protein Pbs21 confers transmission blockade in the mosquito midgut., Mol Biochem Parasitol., 104, 195, 10.1016/S0166-6851(99)00158-9 Trager, 1976, Human malaria parasites in continuous culture., Science., 193, 673, 10.1126/science.781840 Arakawa, 1996, Cloning and sequencing of the VH and V kappa genes of an anti-CD3 monoclonal antibody, and construction of a mouse/human chimeric antibody., J Biochem., 120, 657, 10.1093/oxfordjournals.jbchem.a021462 Chang, 1992, A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth., J Immunol., 149, 548, 10.4049/jimmunol.149.2.548 Julius, 1973, A rapid method for the isolation of functional thymus-derived murine lymphocytes., Eur J Immunol., 3, 645, 10.1002/eji.1830031011 Salmon, 2001, Malaria parasite exit from the host erythrocyte: a two-step process requiring extraerythrocytic proteolysis., Proc Natl Acad Sci U S A., 98, 271, 10.1073/pnas.98.1.271 Lambros, 1976, Synchronization of P. falciparum eythrocytic stages in culture., J Parasitol., 65, 418, 10.2307/3280287 Bouharoun-Tayoun, 1990, Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes., J Exp Med., 172, 1633, 10.1084/jem.172.6.1633 Chang, 1994, Regulation of antibody specificity to Plasmodium falciparum merozoite surface protein-1 by adjuvant and MHC haplotype., J Immunol., 152, 3483, 10.4049/jimmunol.152.7.3483 Gur, 1992, Modulatory effect of aggregating the CD3 molecular complex on T cell activation., Cell Immunol., 140, 81, 10.1016/0008-8749(92)90178-R Tsygankov, 1992, Inhibition of the anti-CD3-induced T cell proliferation by crosslinking of stimulatory antibodies in the presence of PMA and interleukin-2., Cell Immunol., 140, 97, 10.1016/0008-8749(92)90179-S Kwiatkowski, 1989, Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture., Clin Exp Immunol., 77, 361 Peyron, 1990, Plasma levels of tumor necrosis factor during a longitudinal survey in an endemic area of malaria., Acta Trop., 47, 47, 10.1016/0001-706X(90)90006-L Kumaratilake, 1994, T-cell cytokines in malaria: their role in the regulation of neutrophil- and macrophage-mediated killing of Plasmodium falciparum asexual blood forms., Res Immunol., 145, 423, 10.1016/S0923-2494(94)80172-X Jensen, 1989, Malaria crisis forms: intraerythrocytic development derangement. In M. M. Stevenson, ed., Malaria: Host Reponses to Infection., 109 Bouharoun-Tayoun, 1995, Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages., J Exp Med., 182, 409, 10.1084/jem.182.2.409 Kufer, 2001, Minimal costimulatory requirements for T cell priming and TH1 differentiation: activation of naive human T lymphocytes by tumor cells armed with bifunctional antibody constructs., Cancer Immun., 1, 10