Biological actions of galanin

Regulatory Peptides - Tập 59 - Trang 1-16 - 1995
Jacqueline N. Crawley1
1Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4N212, Bethesda 20892-1380, MD 20892, USA

Tài liệu tham khảo

Agoston, 1994, Selective up-regulation of neuropeptide synthesis by blocking the neuronal activity: galanin expression in septohippocampal neurons, Exp. Neurol., 126, 247, 10.1006/exnr.1994.1062 Ahrén, 1989, Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the B-cell?, Peptides, 10, 453, 10.1016/0196-9781(89)90058-2 Allescher, 1989, Inhibitory functions of VIP-PHI and galanin in canine pylorus, Am. J. Physiol., 256, G789 Amiranoff, 1988, Mechanism of galanin-inhibited insulin release: occurrence of a pertussis toxin-sensitive inhibition of adenylate cyclase, Eur. J. Biochem., 177, 147, 10.1111/j.1432-1033.1988.tb14355.x Amiranoff, 1989, Structural requirements for galanin action in the pancreatic B cell line Rin m 5F, Eur. J. Pharmacol., 163, 205, 10.1016/0014-2999(89)90421-4 Anglade, 1994, Characterization of trout galanin and its distribution in trout brain and pituitary, J. Comp. Neurol., 350, 63, 10.1002/cne.903500105 Arrang, 1991, Regulation of histamine release in rat hypothalamus and hippocampus by presynaptic galanin receptors, Peptides, 12, 1113, 10.1016/0196-9781(91)90067-Y Arvidsson, 1994, Expression of neuropeptides in the rat mesencephalic trigeminal nucleus after peripheral axotomy, NeuroReport, 5, 1269, 10.1097/00001756-199406020-00029 Austin, 1990, Tyrosine hydroxylase and galanin mRNA levels in locus coeruleus neurons are increased following reserpine administration, Synapse, 6, 351, 10.1002/syn.890060407 Bartfai, 1991, M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord, 88, 10961 Bartfai, 1992, Galanin and galanin antagonists: molecular and biochemical perspectives, Trends Pharm. Sci., 13, 312, 10.1016/0165-6147(92)90098-Q Bartfai, 1993, Galanin-receptor ligand M40 peptide distinguished between putative galanin-receptor subtypes, 90, 11287 Batten, 1990, Anatomical distribution of galanin-like immunoreactivity in the brain and pituitary of teleost fishes, Neurosci. Lett., 111, 12, 10.1016/0304-3940(90)90336-8 Beal, 1990, Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease, Ann. Neurol., 28, 157, 10.1002/ana.410280207 Ben Ari, 1989, Galanin protects hippocampal neurons from the functional effects of anoxia, Eur. J. Pharmacol., 165, 331, 10.1016/0014-2999(89)90732-2 Benelli, 1994, Galantide stimulates sexual behavior in male rats, Eur. J. Pharmacol., 260, 279, 10.1016/0014-2999(94)90352-2 Bennett, 1992, The effects of various peptides on human isolated gut muscle, J. Pharm. Pharmacol., 44, 960, 10.1111/j.2042-7158.1992.tb07074.x Berrettini, 1988, Galanin immunoreactivity in human CSF: studies in eating disorders and Alzheimer's disease, Neuropsychobiology, 19, 64, 10.1159/000118436 Bersani, 1991, Human galanin: primary structure and identification of two molecular forms, FEBS Lett., 283, 189, 10.1016/0014-5793(91)80585-Q Björkstrand, 1993, Effect of galanin on plasma levels of oxytocin and cholecystokinin, NeuroReport, 4, 10, 10.1097/00001756-199301000-00002 Bloch, 1993, Microinjection of galanin into the medial preoptic nucleus facilitates copulatory behavior in the male rat, Physiol. Behav., 54, 615, 10.1016/0031-9384(93)90068-Q Bloch, 1993, Distribution of galanin-immunoreactive cells within sexually dimorphic components of the medial preoptic area of the male and female rat, Brain Res., 620, 259, 10.1016/0006-8993(93)90164-I Boswell, 1993, NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding, Brain Res. Bull., 32, 379, 10.1016/0361-9230(93)90203-N Botella, 1995, Galanin contracts and relaxes guinea pig and canine intestinal smooth muscle cells through distinct receptors, Gastroenterology, 108, 3, 10.1016/0016-5085(95)90002-0 Botella, 1994, Galanin induces opposite effects via different intracellular pathways in smooth muscle cells from dog colon, Peptides, 15, 637, 10.1016/0196-9781(94)90088-4 Chan-Palay, 1988, Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: a hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia, J. Comp. Neurol., 273, 543, 10.1002/cne.902730409 Chen, 1992, Solubilization and molecular characterization of active galanin receptors from rat brain, Biochemistry, 31, 2415, 10.1021/bi00123a029 Chen, 1993, Purification of a galanin receptor from pig brain, 90, 3845 Chen, 1992, Galanin inhibits adenylate cyclase of rat brain membranes, Peptides, 13, 339, 10.1016/0196-9781(92)90118-M Consolo, 1994, Impulse flow dependency of galanin release in vivo in the rat ventral hippocampus, 91, 8047 Cortés, 1990, Differential effects of intracerebroventricular colchicine administration of the expression of mRNAs for neuropeptides and neurotransmitter enzymes, with special emphasis on galanin: an in situ hybridization study, Synapse, 6, 369, 10.1002/syn.890060410 Cortés, 1990, Effects of central nervous system lesions on the expression of galanin: a comparative in situ hybridization and immunohistochemical study, 87, 7742 Corwin, 1993, Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat, Eur. J. Neurosci., 5, 1528, 10.1111/j.1460-9568.1993.tb00221.x Corwin, R. L., Rowe, P.M. and Crawley, J.N., Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats, Am. J. Physiol., in press. Courtice, 1994, Selective regional vasoconstriction underlying pressor effects of galanin in anesthetized possums compared with cats, J. Physiol. (Lond.), 481, 439, 10.1113/jphysiol.1994.sp020452 Coyle, 1983, Alzheimer's disease: a disorder of cortical cholinergic innervation, Science, 219, 1184, 10.1126/science.6338589 Crawley, 1990, Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus, J. Neurosci., 10, 3695, 10.1523/JNEUROSCI.10-11-03695.1990 Crawley, 1993, Galanin receptor antagonists M40 and C7 block galanin-induced feeding, Brain Res., 600, 268, 10.1016/0006-8993(93)91382-3 De Bilbao, 1991, Age-related changes in galanin-immunoreactive cells of the rat medial septal area, J. Comp. Neurol., 313, 613, 10.1002/cne.903130407 De Loof, 1992, Molecular dynamics simulation of galanin in aqueous and nonaqueous solution, J. Am. Chem. Soc., 114, 4028, 10.1021/ja00037a002 De Weille, 1988, ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonyl ureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone, 85, 1312 Dube, 1994, Naloxone reduces the feeding evoked by intracerebroventricular galanin injection, Physiol. Behav., 56, 811, 10.1016/0031-9384(94)90247-X Dunning, 1992, Reduced pancreatic content of the inhibitory neurotransmitter galanin in genetically obese, hyperinsulinemic mice, Pancreas, 7, 233, 10.1097/00006676-199203000-00016 Dunning, 1990, Pancreatic and extrapancreatic galanin release during sympathetic neural activation, Am. J. Physiol., 258, E436 Dutar, 1989, Galanin blocks the slow cholinergic EPSP in CA1 pyramidal neurons from ventral hippocampus, Eur. J. Pharmacol., 164, 355, 10.1016/0014-2999(89)90477-9 Ekblad, 1985, Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations, Br. J. Pharmac., 86, 241, 10.1111/j.1476-5381.1985.tb09455.x Elfvin, 1994, Immunohistochemical demonstration of galanin, and galanin message-associated peptide-like immunoreactivities in sympathetic ganglia and adrenal gland of the guinea pig, Microsc. Res. Tech., 29, 131, 10.1002/jemt.1070290210 Elmquist, 1993, Developmental profile of galanin binding sites in the mammalian brain, Mol. Cell. Neurosci., 4, 354, 10.1006/mcne.1993.1045 El-Salhy, 1993, Peptidergic innervation and endocrine cells in the human liver, Scan. J. Gastroenterol., 28, 809, 10.3109/00365529309104014 Evans, 1993, Genomic organization and localization of the gene encoding human preprogalanin, Genomics, 18, 473, 10.1016/S0888-7543(11)80002-9 Fisone, 1987, Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies, 84, 7339 Foster, 1992, Differential regulation of tyrosine hydroxylase, neuropeptide Y and galanin gene expression in the pons and medulla oblongata following chronic oral administration of 2% saline: a combined in situ hybridisation and immunohistochemical study, Neuroendocrinology, 55, 544, 10.1159/000126168 Fox, 1988, Actions of galanin fragments on rat, guinea-pig, and canine intestinal motility, Peptides, 9, 1183, 10.1016/0196-9781(88)90105-2 Fox, 1994, Galanin: a novel intraovarian regulatory peptides, Endocrinology, 135, 636, 10.1210/en.135.2.636 Gabriel, 1989, Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat, Peptides, 10, 369, 10.1016/0196-9781(89)90045-4 Gabriel, 1990, Galanin-like immunoreactivity is influenced by estrogen in peripubertal and adult rats, Neuroendocrinology, 51, 168, 10.1159/000125333 Gabriel, 1988, Characterization of galanin-like immunoreactivity in the rat brain: effects of neonatal glutamate treatment, Neurosci. Lett., 87, 114, 10.1016/0304-3940(88)90155-3 Gabriel, 1993, The galanin antagonist, M-15, inhibits growth hormone release in rats, Peptides, 14, 633, 10.1016/0196-9781(93)90156-B Gallwitz, 1990, Galanin: structural requirements for binding and signal transduction in RINm5F insulinoma cells, Biochem. Biophys. Res. Comm., 172, 268, 10.1016/S0006-291X(05)80204-9 Givens, 1992, Galanin in the medial septal area impairs working memory, Brain Res., 582, 71, 10.1016/0006-8993(92)90318-4 Gregersen, 1991, Galanin-induced inhibition of insulin secretion from rat islets: effects of rat and pig galanin and galanin fragments and analogues, Eur. J. Pharmacol., 203, 111, 10.1016/0014-2999(91)90797-T Gregersen, 1993, Blockade of galanin-induced inhibition of insulin secretion from isolated mouse islets by the non-methionine containing antagonist M35, Eur. J. Pharmacol., 232, 35, 10.1016/0014-2999(93)90725-W Gu, 1994, Galanin-induced relaxation in gastric smooth muscle cells is mediated by cyclic AMP, Peptides, 15, 1425, 10.1016/0196-9781(94)90119-8 Gu, 1995, Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: identification of a novel galanin receptor subtype, J. Pharmacol. Exp. Ther., 272, 371 Gu, 1994, Smooth muscle cells from guinea pig stomach possess high-affinity galanin receptors that mediate relaxation, Am. J. Physiol., 266, G839 Gu, 1993, Chimeric galanin analogs that function as antagonists in the CNS are full agonists in gastrointestinal smooth muscle, J. Pharmacol. Exp. Ther., 266, 912 Habert-Ortoli, 1994, Molecular cloning of a functional human galanin receptor, 91, 9780 Hagan, 1988, The cholinergic hypothesis: a review of animal experiments, Vol. 20, 237 Harling, 1992, Circulating galanin: origin, metabolism, and pharmacokinetics in anesthetized pigs, Am. J. Physiol., 262, E52 Henken, 1992, The proportion of galanin-immunoreactive neurons in mouse trigeminal ganglia is transiently increased following corneal inoculation of herpes simplex virus type-1, Neurosci. Lett., 140, 177, 10.1016/0304-3940(92)90096-P Hermansen, 1989, On the nature of the galanin action on the endocrine pancreas: studies with six fragments in the perfused dog pancreas, Acta Endocrinol., 121, 545, 10.1530/acta.0.1210545 Hökfelt, 1992, Central and sensory galanin neurons and functional aspects, Biomed. Res., 13, 311 Hökfelt, 1987, Coexistence of peptides with classical transmitters, Experientia, 43, 768, 10.1007/BF01945354 Hökfelt, 1987, Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy, Neurosci. Lett., 83, 217, 10.1016/0304-3940(87)90088-7 Hökfelt, 1994, Messenger plasticity in primary sensory neurons following axotomy and its functional implications, Trends Neurosci., 17, 22, 10.1016/0166-2236(94)90031-0 Holgert, 1994, Neuronal markers, peptides and enzymes in nerves and chromaffin cells in the rat adrenal medulla during postnatal development, Dev. Brain Res., 83, 35, 10.1016/0165-3806(94)90177-5 Holmes, 1994, Intraventricular administration of galanin does not affect behaviors associated with locus coeruleus activation in rats, Peptides, 7, 1303, 10.1016/0196-9781(94)90158-9 Holmes, P.V. and Crawley, J.N., Olfactory bulbectomy increases preprogalanin and tyrosine hydroxylase mRNA levels in the rat locus coeruleus, submitted. Holst, 1993, On the effects of human galanin in man, Diabetologia, 36, 653, 10.1007/BF00404076 Hsu, 1991, Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas, Am. J. Pathol., 138, 897 Ji, 1994, Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy, 91, 12540 Jimenez, 1994, Distribution of galanin-like immunoreactivity in the brain of the turtle Mauremys caspica, J. Comp. Neurol., 349, 73, 10.1002/cne.903490106 Jozsa, 1993, Galanin-like immunoreactivity in the chicken brain, Cell Tissue Res., 273, 391, 10.1007/BF00312842 Kaplan, 1988, Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary, 85, 7408 Kaplan, 1988, Tissue-specific expression of the rat galanin gene, 85, 1065 Kar, 1994, Galanin receptor binding sites in adult rat spinal cord respond differentially to neonatal capsaicin, dorsal rhizotomy and peripheral axotomy, Eur. J. Neurosci., 6, 1917, 10.1111/j.1460-9568.1994.tb00583.x Kar, 1995, Neuropeptide receptors in developing and adult rat spinal cord: an in vitro quantitative autoradiography study of calcitonin gene-related peptide, neurokinins, μ-opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors, J. Comp. Neuroanat., 354, 253, 10.1002/cne.903540208 Köhler, 1989, Autoradiographic mapping of galanin receptors in the monkey brain, J. Chem. Neuroanat., 2, 269 Konopka, 1989, Characteristics of the galanin-induced depolarization of mudpuppy parasympathetic postganglionic neurons, Neurosci. Lett., 9, 142, 10.1016/0304-3940(89)90279-6 Kowalyk, 1992, Liver releases galanin during sympathetic nerve stimulation, Am. J. Physiol., 262, E671 Kuwahara, 1989, Galanin suppresses neurally evoked contractions of circular muscle in the guinea-pig ileum, Eur. J. Pharmacol., 164, 175, 10.1016/0014-2999(89)90247-1 Kyrkouli, 1990, Peptide-amine interactions in the hypothalamic paraventricular nucleus: analysis of galanin and neuropeptide Y in relation to feeding, Brain Res., 521, 185, 10.1016/0006-8993(90)91541-N Kyrkouli, 1992, Differential effects of galanin and neuropeptide Y on extracellular norepinephrine levels in the paraventricular hypothalamic nucleus of the rat: a microdialysis study, Life Sci., 51, 203, 10.1016/0024-3205(92)90076-2 Kyrkouli, 1986, Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide, Eur. J. Pharmacol., 122, 159, 10.1016/0014-2999(86)90175-5 Kyrkouli, 1990, Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide's effects in the brain, Peptides, 11, 995, 10.1016/0196-9781(90)90023-X Lagny-Pourmir, 1989, Characterization of galanin receptors in the insulin-secreting cell line Rin m 5F: evidence for coupling with a pertussis toxin-sensitive guanosine triphosphate regulatory protein, Endocrinology, 124, 2635, 10.1210/endo-124-5-2635 Lagny-Pourmir, 1992, Regional stimulatory and inhibitory effects of guanine nucleotides on [125I] galanin binding in rat brain: relationship with the rate of occupancy of galanin receptors by endogenous galanin, Neuroscience, 49, 829, 10.1016/0306-4522(92)90360-E Lagny-Pourmir, 1989, Structural requirements for galanin interactions with receptors from pancreatic beta cells and from brain tissue of the rat, Peptides, 10, 757, 10.1016/0196-9781(89)90109-5 Land, 1991, Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor, Int. J. Pept. Protein Res., 38, 267, 10.1111/j.1399-3011.1991.tb01438.x Langel, 1992, Design of chimeric peptide ligands to galanin receptors and substance P receptors, Int. J. Pept. Protein Res., 39, 516, 10.1111/j.1399-3011.1992.tb00282.x Lazar, 1991, Distribution of galanin-like immunoreactivity in the brain of Rana esculenta and Xenopus laevis, J. Comp. Neurol., 310, 45, 10.1002/cne.903100106 Leibowitz, 1992, Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion, Brain Res., 599, 148, 10.1016/0006-8993(92)90863-5 Leonhardt, 1989, Galanin inhibits glucose-induced insulin release in vitro, Horm. Metabol. Res., 21, 100, 10.1055/s-2007-1009161 Lichtenstein, 1994, Localization and inhibitory actions of galanin at the feline lower esophageal sphincter, Regul. Pept., 50, 213, 10.1016/0167-0115(94)90002-7 Lindskog, 1992, The novel high affinity antagonist galantide blocks the galanin mediated inhibition of glucose-induced insulin secretion, Eur. J. Pharmacol., 210, 183, 10.1016/0014-2999(92)90669-U Lindskog, 1990, Galanin of the homologous species inhibits insulin secretion in the rat and in the pig, Acta Physiol. Scand., 139, 591, 10.1111/j.1748-1716.1990.tb08963.x Liu, 1994, Protective effect of galanin on behavioral deficits in experimental traumatic brain injury, J. Neurotrauma, 11, 73, 10.1089/neu.1994.11.73 Longley, 1993, Proportions of renal and splenic postganglionic sympathetic populations containing galanin and dopamine beta hydroxylase, Neuroscience, 55, 253, 10.1016/0306-4522(93)90470-Z Lopez, 1990, Development and characterization of a specific and sensitive radioimmunoassay for rat galanin: measurement in brain tissue, hypophyseal portal and peripheral serum, Brain Res. Bull., 24, 395, 10.1016/0361-9230(90)90095-H Lopez, 1991, Galanin: a hypothalamic-hypophysiotropic hormone modulating reproductive functions, 88, 4508 Lundquist, 1991, Galanin immunoreactivity in the blowfly nervous system: localization and chromatographic analysis, J. Comp. Neurol., 312, 77, 10.1002/cne.903120107 Maggi, 1987, Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder, Eur. J. Pharmacol., 143, 135, 10.1016/0014-2999(87)90744-8 Maiter, 1990, Galanin is a physiological regulator of spontaneous pulsatile secretion of growth hormone in the male rat, Endocrinology, 126, 1216, 10.1210/endo-126-2-1216 Malin, 1992, Galanin attenuates retention of one-trial reward learning, Life Sci., 50, 939, 10.1016/0024-3205(92)90171-K Marks, 1993, Regulation of gonadotropin-releasing hormone (GnRH) and galanin gene expression in the GnRH neurons during lactation in the rat, Endocrinology, 133, 1450, 10.1210/en.133.3.1450 Mastropaolo, 1988, Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats, 85, 9841 Mazancourt, 1994, Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3, Biochem. J., 303, 369, 10.1042/bj3030369 Mazarati, 1992, Anticonvulsive effects of galanin administered into the central nervous system upon the picrotoxin-kindled seizure syndrome in rats, Brain Res., 589, 164, 10.1016/0006-8993(92)91179-I McDonald, 1985, Galanin inhibits insulin secretion and induces hyperglycemia in dogs, Diabetes, 34, 192, 10.2337/diabetes.34.2.192 McDonald, 1994, Canine, human, and rat plasma insulin responses to galanin administration: species response differences, Am. J. Physiol., 266, E612 McKeon, 1990, Distribution of galanin-like peptide in various tissues of Necturus maculosus, Cell Tissue Res., 262, 461, 10.1007/BF00305242 Melander, 1986, Distribution of galanin-like immunoreactivity in the rat central nervous system, J. Comp. Neurol., 248, 475, 10.1002/cne.902480404 Melander, 1986, Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS, J. Neurosci., 6, 3640, 10.1523/JNEUROSCI.06-12-03640.1986 Melander, 1988, Autoradiographic quantitation and anatomical mapping of125I-galanin binding sites in the rat central nervous system, J. Chem. Neuroanat., 1, 213 Merchenthaler, 1993, Anatomy and physiology of central galanin-containing pathways, Prog. Neurobiol., 40, 711, 10.1016/0301-0082(93)90012-H Merchenthaler, 1990, Colocalization of galanin and luteinizing hormone-releasing hormone in a subset of preoptic hypothalamic neurons: anatomical and functional correlates, 87, 6326 Miller, 1993, Extra-hypothalamic vasopressin neurons coexpress galanin messenger RNA as shown by double in situ hybridization histochemistry, J. Comp. Neurol., 329, 378, 10.1002/cne.903290308 Miller, 1993, Testosterone regulates galanin gene expression in the bed nucleus of the stria terminalis, Brain Res., 611, 338, 10.1016/0006-8993(93)90523-P Mohney, 1994, Galanin and vasoactive intestinal peptide messenger RNAs increase following axotomy of adult sympathetic neurons, J. Neurobiol., 25, 108, 10.1002/neu.480250203 Mufson, 1993, Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome, Dementia, 4, 237 Nahin, 1994, Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain, Pain, 58, 95, 10.1016/0304-3959(94)90189-9 Norberg, 1991, Chemical detection of natural peptides by specific structures, FEBS Lett., 288, 151, 10.1016/0014-5793(91)81023-2 Ögren, 1992, Evidence for a role of the neuropeptide galanin in spatial learning, Neuroscience, 51, 1, 10.1016/0306-4522(92)90463-C Ohhashi, 1985, Galanin potentiates electrical stimulation and exogenous norepinephrine-induced contractions in the rat vas deferens, Regul. Pept., 12, 163, 10.1016/0167-0115(85)90197-1 Ohno, 1994, Occurrence of galanin-like immunoreactivity in vestibular and cochlear efferent neurons after labyrinthectomy in the rat, Brain Res., 644, 135, 10.1016/0006-8993(94)90356-5 Ottlecz, 1988, Regulatory role of galanin in control of hypothalamic-anterior pituitary function, 85, 9861 Palazzi, 1991, Galanin reduces carbachol stimulation of phosphoinoside turnover in rat ventral hippocampus by lowering Ca2+ influx through voltage-sensitive Ca2+ channels, J. Neurochem., 56, 739, 10.1111/j.1471-4159.1991.tb01986.x Pieribone, 1995, Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice, Neuroscience, 64, 861, 10.1016/0306-4522(94)00450-J Planas, 1995, Sex differences in coexpression by galanin neurons accounts for sexual dimorphism of vasopressin in the bed nucleus of the stria terminalis, Endocrinology, 136, 727, 10.1210/en.136.2.727 Poggioli, 1992, Galanin inhibits sexual behavior in male rats, Eur. J. Pharmacol., 213, 87, 10.1016/0014-2999(92)90236-W Rada, 1994, Effects of paraventricular galanin and neuropeptide Y on dopamine and acetylcholine in the nucleus accumbens of freely moving rats, Soc. Neurosci. Abstr., 20, 656.6 Rao, 1993, Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons, Neuron, 11, 1175, 10.1016/0896-6273(93)90229-K Rattan, 1987, Effect of galanin on the opossum lower esophageal sphincter, Life Sci., 41, 2783, 10.1016/0024-3205(87)90423-1 Reimann, 1994, Spinal antinociception by morphine in rats is antagonised by galanin receptor antagonists, Naunyn-Schmiedeberg's Arch. Pharmacol., 350, 380, 10.1007/BF00178955 Reimann, 1993, Galanin receptor activation attenuates norepinephrine release from rat spinal cord slices, Life Sci., 52, 251, 10.1016/0024-3205(93)90473-G Robinson, 1993, Intraventricular galanin impairs delayed non-matching to sample performance in rats, Behav. Neurosci., 107, 458, 10.1037/0735-7044.107.3.458 Robinson, 1993, Intraseptal galanin potentiates scopolamine disruption of delayed non-matching to sample, J. Neurosci., 13, 5119, 10.1523/JNEUROSCI.13-12-05119.1993 Robinson, 1994, Analysis of anatomical sites at which galanin impairs delayed nonmatching to sample in rats, Behav. Neurosci., 108, 941, 10.1037/0735-7044.108.5.941 Robinson, J.K., Zocchi, A., Pert, A. and Crawley, J.N., Galanin microinjected into the medial septum attenuates scopolamine-induced acetylcholine overflow in the rat ventral hippocampus, submitted. Rökeaus, 1987, Galanin: a newly isolated biologically active neuropeptide, Trends Neurosci., 10, 158 Rökeaus, 1986, Construction of a porcine adrenal medullary cDNA library and nucleotide sequence analysis of two clones encoding a galanin precursor, 83, 6287 Rökeaus, 1988, Nucleotide sequence analysis of cDNAs encoding a bovine galanin precursor protein in the adrenal medulla and chemical isolation of bovine gut galanin, FEBS Lett., 234, 400, 10.1016/0014-5793(88)80125-X Rossowski, 1989, Inhibitory action of galanin on gastric acid secretion in pentobarbital-anesthetized rats, Life Sci., 44, 1807, 10.1016/0024-3205(89)90297-X Rossowski, 1990, Galanin binding sites in rat gastric and jejunal smooth muscle membrane preparations, Peptides, 11, 333, 10.1016/0196-9781(90)90089-N Rossowski, 1993, Galanin: structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction, Eur. J. Pharmacol., 240, 259, 10.1016/0014-2999(93)90907-Y Scheurink, 1992, α2-Adrenergic regulation of galanin and norepinephrine from canine pancreas, Am. J. Physiol., 262, R819 Schick, 1993, Effect of galanin on food intake in rats: involvement of lateral and ventromedial hypothalamic sites, Am. J. Physiol., 264, R355 Schmidt, 1991, Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide, 88, 11435 Schnuerer, 1987, Inhibition of insulin release by galanin and gastrin-releasing peptide in the anesthetized rat, Regul. Pept., 18, 307, 10.1016/0167-0115(87)90188-1 Sethi, 1991, Galanin stimulates Ca2+ mobilization, inositol phosphate accumulation, and clonal growth in small cell lung cancer cells, Cancer Res., 51, 1674 Seutin, 1989, Galanin decreases the activity of locus coeruleus neurons in vitro, Eur. J. Pharmacol., 164, 373, 10.1016/0014-2999(89)90481-0 Shew, 1992, Galanin and calcitonin gene-related peptides immunoreactivity in nerves of the rat uterus: localization, colocalization, and effects on uterine contractility, Peptides, 13, 273, 10.1016/0196-9781(92)90108-F Sillard, 1992, Variant forms of galanin isolated from porcine brain, Peptides, 13, 1055, 10.1016/0196-9781(92)90005-N Sizer, 1990, Analysis of the ontogeny of galanin in the rat central nervous system by immunohistochemistry and radioimmunoassay, Int. J. Dev. Neurosci., 8, 81, 10.1016/0736-5748(90)90025-W Skofitsch, 1986, Quantitative distribution of galanin-like immunoreactivity in the rat central nervous system, Peptides, 7, 609, 10.1016/0196-9781(86)90035-5 Skofitsch, 1986, Autoradiographic distribution of125I-galanin binding sites in the rat central nervous system, Peptides, 7, 1029, 10.1016/0196-9781(86)90133-6 Smith, 1994, Chronic cere-broventricular galanin does not induce sustained hyperphagia or obesity, Peptides, 15, 1267, 10.1016/0196-9781(94)90152-X Soldani, 1988, An analysis of the effects of galanin on gastric acid secretion and plasma levels of gastrin in the dog, Eur. J. Pharmacol., 154, 313, 10.1016/0014-2999(88)90207-5 Sundstrom, 1988, Galanin impairs acquisition but not retrieval of spatial memory in rats studies in the Morris swim maze, Neurosci. Lett., 88, 331, 10.1016/0304-3940(88)90233-9 Takahashi, 1994, Modulation of neurotransmission in guinea-pig airways by galanin and the effect of a new antagonist galantide, Neuropeptides, 26, 245, 10.1016/0143-4179(94)90078-7 Tamura, 1987, Galanin suppresses nicotinic synaptic transmission in the myenteric plexus of guinea-pig small intestine, Eur. J. Pharmacol., 136, 445, 10.1016/0014-2999(87)90323-2 Tatemoto, 1983, Galanin -a novel biologically active peptide from porcine intestine, FEBS Lett., 164, 124, 10.1016/0014-5793(83)80033-7 Tempel, 1988, Effects of PVN galanin on macronutrient selection, Peptides, 9, 309, 10.1016/0196-9781(88)90265-3 Tempel, 1990, Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN, Brain Res. Bull., 25, 821, 10.1016/0361-9230(90)90177-2 Torsello, 1992, Steroid and tissue-specific modulation of galanin gene expression in the male reproductive system, Endocrinology, 130, 3301, 10.1210/en.130.6.3301 Tsuda, 1992, Modulation of norepinephrine release by galanin in rat medulla oblongata, Hypertension, 20, 361, 10.1161/01.HYP.20.3.361 Ullrich, 1989, Galanin inhibits insulin secretion by direct interference with exocytosis, FEBS Lett., 247, 401, 10.1016/0014-5793(89)81379-1 Ulman, 1992, Effects of human, rat and porcine galanins on cardiac vagal action and blood pressure in the anesthetized cat, Neurosci. Lett., 136, 105, 10.1016/0304-3940(92)90659-U Ulman, 1994, Functional effects of a family of galanin antagonists on the cardiovascular system in anesthetized cats, Regul. Pept., 51, 17, 10.1016/0167-0115(94)90130-9 Vrontakis, 1987, Isolation and characterization of a complementary DNA (Galanin) clone from estrogen-induced pituitary tumor messenger RNA, J. Biol. Chem., 262, 16755, 10.1016/S0021-9258(18)45446-4 Vrontakis, 1990, Presence of galanin-like immunoreactivity in nontumorous corticotrophs and corticotrophic adenomas of the human pituitary, J. Clin. Endocrinol. Metab., 70, 747, 10.1210/jcem-70-3-747 Vrontakis, 1989, Estrogen induction of galanin synthesis in the rat anterior pituitary gland demonstrated by in situ hybridization and immunohistochemistry, Neurosci. Lett., 100, 59, 10.1016/0304-3940(89)90660-5 Walli, 1994, Identification and biochemical characterization of the human brain galanin receptor, J. Mol. Endocrinol., 13, 347, 10.1677/jme.0.0130347 Wang, 1994, Purification and primary structure of galanin from the alligator stomach, Peptides, 15, 603, 10.1016/0196-9781(94)90082-5 Wang, 1995, Distribution of galanin-immunoreactive nerves in the canine gastrointestinal tract, Peptides, 16, 237, 10.1016/0196-9781(94)00170-7 White, 1994, Evidence for survival of the central arbors of trigeminal primary afferents after peripheral neonatal axotomy: experiments with galanin immunocytochemistry and Di-I labelling, J. Comp. Neurol., 350, 397, 10.1002/cne.903500306 Wiesenfeld-Hallin, 1992, Galanin in sensory neurons in spinal cord, Front. Neuroendocrinol., 13, 319 Wiesenfeld-Hallin, 1989, The effects of intrathecal galanin and C-fiber stimulation on the flexor reflex in the rat, Brain Res., 486, 205, 10.1016/0006-8993(89)90506-4 Wiesenfeld-Hallin, 1990, PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes, 87, 7105 Wiesenfeld-Hallin, 1992, Galanin-mediated control of pain: enhanced role after nerve injury, 89, 3334 Wiesenfeld-Hallin, 1990, Intrathecal galanin potentiates the spinal analgesic effect of morphine: electrophysiological and behavioral studies, Neurosci. Lett., 109, 217, 10.1016/0304-3940(90)90566-R Wong, 1994, Purification and primary structure of galanin from alligator stomach, Peptides, 15, 603, 10.1016/0196-9781(94)90082-5 Wynick, 1993, Galanin regulates basal and oestrogen-stimulated lactotroph function, Nature, 364, 529, 10.1038/364529a0 Wynick, 1993, Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor, 90, 4231 Young, 1990, The influences of hyperosmolality and synaptic inputs on galanin and vasopressin expression in the hypothalamus, Neuroscience, 39, 115, 10.1016/0306-4522(90)90226-T Zhang, 1993, Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin, Exp. Brain Res., 93, 450, 10.1007/BF00229360 Zhang, 1994, Increased expression of galanin in the rat superior cervical ganglion after pre-and postganglionic nerve lesions, Exp. Neurol., 127, 9, 10.1006/exnr.1994.1075 Zhang, 1994, Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425, 10.1038/372425a0 Zini, 1993, Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus, Eur. J. Pharmacol., 245, 1, 10.1016/0922-4106(93)90162-3