A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers

Microorganisms - Tập 8 Số 8 - Trang 1162
Д. А. Каштанова1,2, Natalia Klimenko3, И. Д. Стражеско2, Elizaveta V. Starikova4, Oksana E. Glushchenko4, Denis Gudkov4, О. Н. Ткачева2
1Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical-Biological Agency, 119435 Moscow, Russia
2The Stand-Alone Structural Unit of the Pirogov Russian National Research Medical University the "Russian Clinical Research Center for Gerontology" of the Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia
3Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia
4Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia

Tóm tắt

The aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups of patients who signed their consent to participate. The group of long-livers (LL) included 20 participants aged 97–100 years (4 men and 16 women). The second group included 22 participants aged 60–76 years (6 men) without clinical manifestations of chronic diseases (healthy elderly). Gut microbiota was studied by 16S rRNA sequencing. Long-livers underwent a complex geriatric assessment as well as expanded blood biochemistry. Gut microbiota composition in the cohorts was also compared with microbiome in long-livers from Japan and Italy. Russian long-livers’ microbiome contained more beneficial bacteria than healthy elderly including Ruminococcaceae, Christensenellaceae, Lactobacillaceae families. Conditional pathogens like Veillonellaceae, Mogibacteriaceae, Alcaligenaceae, Peptococcaceae, Peptostreptococcaceae were more abundant in the healthy elderly. Compared with Italian and Japanese microbiome LL, the Russian LL appeared to be more similar to the Italian cohort. Bifidobacterium/Coprococcus and Faecalibacterium/Coprococcus balances were associated with femoral and carotid intima–media thickness, respectively. Bifidobacterium/Coriobacteriaceae balance was assessed with the folic acid level and Faecalibacterium/Coriobacteriaceae_u the with Mini Nutritional Assessment score. Long-livers’ microbiome appeared to be unexpectedly balanced. The high representation of beneficial bacteria in long-livers may prevent them from low-grade inflammation and thus protect them from the development of atherosclerosis and other aging-associated conditions.

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Microorganisms

Tập 8 Số 8

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