Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line

Aizenman, 1986, Changes in insulin and transferrin requirements of pure brain neuronal cultures during embryonic development, 83, 2263 Choi, 1992, Excitotoxic cell death, J. Neurobiol., 23, 1261, 10.1002/neu.480230915 Cook, 1989, Viability measurements in mammalian cell systems, Anal. Biochem., 179, 1, 10.1016/0003-2697(89)90191-7 Di Virgilio, 1986, Tumor promoter phorbol myristate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F, J. Biol. Chem., 261, 32, 10.1016/S0021-9258(17)42424-0 Favaron, 1990, Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death, 87, 1983 Felipo, 1993, Inhibitors of protein kinase C prevent toxicity of glutamate in primary neuronal cultures, Brain Res., 604, 192, 10.1016/0006-8993(93)90368-W Halliwell, 1993 Hansen, 1989, Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill, J. Immunol. Methods, 119, 203, 10.1016/0022-1759(89)90397-9 Kiyoto, 1987, Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decar☐ylase induction in isolated mouse epidermal cells, Biochem. Biophys. Res. Commun., 148, 740, 10.1016/0006-291X(87)90938-7 Mattson, 1989, Fibroblast growth factor and glutamate: opposing actions in the generation and degeneration of hippocampal neuroarchitecture, J. Neurosci., 9, 3728, 10.1523/JNEUROSCI.09-11-03728.1989 Miyamoto, 1989, Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line, J. Pharmacol. Exp. Ther., 250, 1132 Morimoto, 1990, Induction and expression of long and short term neurosecretory potentiation in a neural cell line, Neuron, 5, 875, 10.1016/0896-6273(90)90347-I Murphy, 1989, Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress, Neuron, 2, 1547, 10.1016/0896-6273(89)90043-3 Murphy, 1990, Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake, FASEB J., 4, 1624, 10.1096/fasebj.4.6.2180770 Nishizuka, 1988, The molecular heterogeneity of protein kinase C and its implications for cellular regulation, Nature, 334, 661, 10.1038/334661a0 Oka, 1993, Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms and prevention, J. Neurosci., 13, 1441, 10.1523/JNEUROSCI.13-04-01441.1993 Rice, 1986, Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistance in vitro and in vivo, Cancer Res., 46, 6105 Schubert, 1992, Growth factors and vitamin E modify neuronal glutamate toxicity, 89, 8264 Wakade, 1988, Excess K+ and phorbol ester activate protein kinase C and support the survival of chick sympathetic neurons in culture, J. Neurochem., 51, 975, 10.1111/j.1471-4159.1988.tb01835.x Wolf, 1988, The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes, Biochem. Biophys. Res. Commun., 154, 1273, 10.1016/0006-291X(88)90277-X