Carnosic acid attenuates obesity‐induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J‐ob/ob mice

Journal of the Science of Food and Agriculture - Tập 95 Số 4 - Trang 828-835 - 2015
Mi‐Young Park1, Mi‐Kyung Sung2
1Department of Food and Nutrition, Graduate School of Education, Soonchunhyang University, Asan, Chungnam, 336-745, Korea.
2Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, Korea

Tóm tắt

AbstractBACKGROUNDCarnosic acid (CA), a major bioactive component of rosemary (Rosmarinus officinalis) leaves, is known to possess antioxidant and anti‐adipogenic activities. In this study it was hypothesized that CA would ameliorate obesity‐induced glucose intolerence and hepatic fat accumulation, and possible mechanisms are suggested.RESULTSIt was observed that a 0.02% (w/w) CA diet effectively decreased body weight, liver weight and blood triglyceride (TG) and total cholesterol levels (P < 0.05) compared with the control diet. CA at 0.02% significantly improved glucose tolerance, and hepatic TG accumulation was reduced in a dose‐dependent manner. Hepatic lipogenic‐related gene (L‐FABP, SCD1 and FAS) expression decreased whereas lipolysis‐related gene (CPT1) expression increased in animals fed the 0.02% CA diet (P < 0.05). Long‐chain fatty acid content and the ratio of C18:1/C18:0 fatty acids were decreased in adipose tissue of animals fed the 0.02% CA diet (P < 0.05). Serum inflammatory mediators were also decreased significantly in animals fed the 0.02% CA diet compared with those of the obese control group (P < 0.05).CONCLUSIONThese results suggest that CA is an effective anti‐obesity agent that regulates fatty acid metabolism in C57BL/6J‐ob/ob mice. © 2014 Society of Chemical Industry

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Journal of the Science of Food and Agriculture

Tập 95 Số 4

828-835

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