Sustained response with rituximab in patients with thrombotic thrombocytopenic purpura: A report of 13 cases and review of the literature

American Journal of Hematology - Tập 84 Số 7 - Trang 418-421 - 2009
Huichung Tina Ling1, Joshua J. Field1, Morey A. Blinder1,2
1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri
2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri

Tóm tắt

AbstractIdiopathic thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disease mediated by autoantibodies directed against ADAMTS‐13. A number of small series and case reports have shown promising results with rituximab in refractory or relapsed TTP. In this report, we present 13 patients with TTP treated with rituximab. Twelve of the 13 patients (92%) achieved complete response; no subsequent relapses occurred with median follow‐up of 24 months (range, 13–84 months). The addition of rituximab to standard therapy appears to be effective in sustaining long‐term remission in TTP. However, the optimal dosing and timing of rituximab warrant further investigation. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.

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Thông tin
Thông tin xuất bản

American Journal of Hematology

Tập 84 Số 7

418-421

Thông tin tác giả