Phenolic composition, antioxidant potential and health benefits of citrus peel

Food Research International - Tập 132 - Trang 109114 - 2020
Balwinder Singh1, Jatinder Pal Singh2, Amritpal Kaur2, Narpinder Singh2
1P.G. Department of Biotechnology, Khalsa College, Amritsar 143002, Punjab, India
2Department of Food Science and Technology, Guru Nanak Dev University, Amritsar 143005, Punjab, India

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Adeniyi, 2017, Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model, Journal of Integrative Medicine, 15, 158, 10.1016/S2095-4964(17)60327-3

Al-Ashaal, 2011, Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines, Pharmaceutical biology, 49, 276, 10.3109/13880209.2010.509734

Al-Saman, 2019, Antimicrobial and antioxidant activities of different extracts of the peel of kumquat (Citrus japonica Thunb), Journal of Food Measurement and Characterization, 13, 3221, 10.1007/s11694-019-00244-y

Ameer, 1996, Flavanone absorption after naringin, hesperidin, and citrus administration, Clinical Pharmacology & Therapeutics, 60, 34, 10.1016/S0009-9236(96)90164-2

Anagnostopoulou, 2005, Analysis of antioxidant compounds in sweet orange peel by HPLC–diode array detection–electrospray ionization mass spectrometry, Biomedical Chromatography, 19, 138, 10.1002/bmc.430

Anagnostopoulou, 2006, Radical scavenging activity of various extracts and fractions of sweet orange peel (Citrus sinensis), Food Chemistry, 94, 19, 10.1016/j.foodchem.2004.09.047

Apraj, 2016, Evaluation of skin anti-aging potential of Citrus reticulata blanco peel, Pharmacognosy Research, 8, 160, 10.4103/0974-8490.182913

Ashraf, 2017, Citrus peel extract and powder attenuate hypercholesterolemia and hyperglycemia using rodent experimental modeling, Asian Pacific Journal of Tropical Biomedicine, 7, 870, 10.1016/j.apjtb.2017.09.012

Baldi, 1995, Identification of nonvolatile components in lemon peel by high-performance liquid chromatography with confirmation by mass spectrometry and diode-array detection, Journal of Chromatography A, 718, 89, 10.1016/0021-9673(95)00676-1

Ballistreri, 2019, Anthocyanins and other polyphenols in citrus genus: Biosynthesis, chemical profile, and biological activity, 191

Banerjee, 2017, Bioactives from fruit processing wastes: Green approaches to valuable chemicals, Food chemistry, 225, 10, 10.1016/j.foodchem.2016.12.093

Benavente-Garcia, 2008, Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity, Journal of Agricultural and Food Chemistry, 56, 6185, 10.1021/jf8006568

Bocco, 1998, Antioxidant activity and phenolic composition of citrus peel and seed extracts, Journal of Agricultural and Food Chemistry, 46, 2123, 10.1021/jf9709562

Bohn, 2014, Dietary factors affecting polyphenol bioavailability, Nutrition Reviews, 72, 429, 10.1111/nure.12114

Boysen, 2010, High performance liquid chromatographic separation methods, 5

Bustamante, 2016, Microwave-assisted hydro-distillation of essential oils from wet citrus peel waste, Journal of Cleaner Production, 137, 598, 10.1016/j.jclepro.2016.07.108

Buyukkurt, 2019, Characterization of phenolic compounds in sweet lime (Citrus limetta) peel and freshly squeezed juices by LC-DAD-ESI-MS/MS and their antioxidant activity, Journal of Food Measurement and Characterization, 13, 3242, 10.1007/s11694-019-00246-w

Cai, 2020, Impact of particle size of pulverized citrus peel tissue on changes in antioxidant properties of digested fluids during simulated in vitro digestion, Food Science and Human Wellness, 10.1016/j.fshw.2019.12.008

Cardona, 2013, Benefits of polyphenols on gut microbiota and implications in human health, The Journal of Nutritional Biochemistry, 24, 1415, 10.1016/j.jnutbio.2013.05.001

Casquete, 2015, Evaluation of the effect of high pressure on total phenolic content, antioxidant and antimicrobial activity of citrus peels, Innovative Food Science & Emerging Technologies, 31, 37, 10.1016/j.ifset.2015.07.005

Castro-Muñoz, 2016, Phenolic compounds recovered from agro-food by-products using membrane technologies: An overview, Food Chemistry, 213, 753, 10.1016/j.foodchem.2016.07.030

Chan, 2009, Optimisation of extraction conditions for phenolic compounds from limau purut (Citrus hystrix) peels, International Food Research Journal, 16, 203

Chau, 2003, In vitro hypoglycemic effects of different insoluble fiber-rich fractions prepared from the peel of Citrus sinensis L. cv. Liucheng, Journal of Agricultural and Food Chemistry, 51, 6623, 10.1021/jf034449y

Chau, 2005, Improvement in intestinal function and health by the peel fibre derived from Citrus sinensis L cv Liucheng, Journal of the Science of Food and Agriculture, 85, 1211, 10.1002/jsfa.2082

Chavan, 2018, Recent progress in the utilization of industrial waste and by-products of citrus fruits: A review, Journal of Food Process Engineering, 41, e12895, 10.1111/jfpe.12895

Cheigh, 2012, Enhanced extraction of flavanones hesperidin and narirutin from Citrus unshiu peel using subcritical water, Journal of Food Engineering, 110, 472, 10.1016/j.jfoodeng.2011.12.019

Chen, 1997, Two new polymethoxylated flavones, a class of compounds with potential anticancer activity, isolated from cold pressed dancy tangerine peel oil solids, Journal of Agricultural and Food Chemistry, 45, 364, 10.1021/jf960110i

Chen, 2011, Effects of drying temperature on the flavonoid, phenolic acid and antioxidative capacities of the methanol extract of citrus fruit (Citrus sinensis (L.) Osbeck) peels, International Journal of Food Science & Technology, 46, 1179, 10.1111/j.1365-2621.2011.02605.x

Chen, 2017, Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities, Food Chemistry, 218, 15, 10.1016/j.foodchem.2016.09.016

Chen, 2012, Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress, Food Chemistry, 135, 2119, 10.1016/j.foodchem.2012.07.041

Cheong, 2012, Characterisation of calamansi (Citrus microcarpa). Part I: Volatiles, aromatic profiles and phenolic acids in the peel, Food Chemistry, 134, 686, 10.1016/j.foodchem.2012.02.162

Cho, 2014, Determination of flavonoid glycosides, polymethoxyflavones, and coumarins in herbal drugs of citrus and poncirus fruits by high performance liquid chromatography–electrospray ionization/tandem mass spectrometry, Analytical Letters, 47, 1299, 10.1080/00032719.2013.871548

Choi, 2011, Effects of storage period and heat treatment on phenolic compound composition in dried Citrus peels (Chenpi) and discrimination of Chenpi with different storage periods through targeted metabolomic study using HPLC-DAD analysis, Journal of Pharmaceutical and Biomedical Analysis, 54, 638, 10.1016/j.jpba.2010.09.036

Choi, 2007, Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-κB and ROS production in LPS-activated RAW 264.7 cells, Journal of Ethnopharmacology, 113, 149, 10.1016/j.jep.2007.05.021

Choi, 2007, Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits, Biological and Pharmaceutical Bulletin, 30, 772, 10.1248/bpb.30.772

Costa, 2019, Solid-phase microextraction-gas chromatography and ultra-high performance liquid chromatography applied to the characterization of lemon wax, a waste product from citrus industry, Journal of Chromatography A, 1603, 262, 10.1016/j.chroma.2019.06.049

Craft, 2012, Phenol-based antioxidants and the in vitro methods used for their assessment, Comprehensive Reviews in Food Science and Food Safety, 11, 148, 10.1111/j.1541-4337.2011.00173.x

Dahmoune, 2013, Valorization of Citrus limon residues for the recovery of antioxidants: Evaluation and optimization of microwave and ultrasound application to solvent extraction, Industrial Crops and Products, 50, 77, 10.1016/j.indcrop.2013.07.013

Datla, 2001, Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease, Neuroreport, 12, 3871, 10.1097/00001756-200112040-00053

de Moraes Barros, 2012, Antioxidant capacity and mineral content of pulp and peel from commercial cultivars of citrus from Brazil, Food Chemistry, 134, 1892, 10.1016/j.foodchem.2012.03.090

Di Rauso Simeone, 2020, Variations of peel essential oils during fruit ripening in four lemon (Citrus limon (L.) Burm. F.) cultivars, Journal of the Science of Food and Agriculture, 100, 193, 10.1002/jsfa.10016

Dias, 2015, Microencapsulation of bioactives for food applications, Food & Function, 6, 1035, 10.1039/C4FO01175A

Duan, 2017, Polymethoxyflavones in peel of Citrus reticulata ‘Chachi’and their biological activities, Food Chemistry, 234, 254, 10.1016/j.foodchem.2017.05.018

El-aal, 2010, Food preservative activity of phenolic compounds in orange peel extracts (Citrus sinensis L.), Lucrări Ştiinţifice, 53, 233

Esfanjani, 2018, Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers, Trends in Food Science & Technology, 76, 56, 10.1016/j.tifs.2018.04.002

Evans, 2012, Bioavailability of citrus polymethoxylated flavones and their biological role in metabolic syndrome and hyperlipidemia, Readings in advanced pharmacokinetics-Theory, methods and applications. Intech, 267

Fayek, 2017, Comparative study of the hypocholesterolemic, antidiabetic effects of four agro-waste Citrus peels cultivars and their HPLC standardization, Revista Brasileira de Farmacognosia, 27, 488, 10.1016/j.bjp.2017.01.010

Ferreira, 2017, Phenolic compounds and its bioavailability: In vitro bioactive compounds or health promoters?, Advances in food and nutrition research, Vol. 82, 1, 10.1016/bs.afnr.2016.12.004

Ferreira, 2018, Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds, Industrial Crops and Products, 111, 141, 10.1016/j.indcrop.2017.10.009

Food and Agriculture Organization, 2017

Gao, 2018, Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones, Journal of Functional Foods, 40, 498, 10.1016/j.jff.2017.11.036

Ghanem, 2012, Microwave dehydration of three citrus peel cultivars: Effect on water and oil retention capacities, color, shrinkage and total phenols content, Industrial Crops and Products, 40, 167, 10.1016/j.indcrop.2012.03.009

Ghasemi, 2009, Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues, Pakistan Journal of Pharmaceutical Sciences, 22, 277

Gómez-Mejía, 2019, Citrus peels waste as a source of value-added compounds: Extraction and quantification of bioactive polyphenols, Food Chemistry, 295, 289, 10.1016/j.foodchem.2019.05.136

González-Mas, 2019, Volatile compounds in Citrus essential oils: A comprehensive review, Frontiers in Plant Science, 10, 12, 10.3389/fpls.2019.00012

Gorinstein, 2001, Comparison of some biochemical characteristics of different citrus fruits, Food Chemistry, 74, 309, 10.1016/S0308-8146(01)00157-1

Green, 2011, Histopathological alterations in organ structures of hypercholesterolemic rats fed Ortanique peel polymethoxylated flavones, Basic and Applied Pathology, 4, 71

Green, 2011, Hypolipidemic effects of ortanique peel polymethoxylated flavones in rats with diet-induced hypercholesterolemia, Journal of Food Biochemistry, 35, 1555, 10.1111/j.1745-4514.2010.00479.x

Green, 2007, Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography, Biomedical Chromatography, 21, 48, 10.1002/bmc.718

Guimarães, 2010, Targeting excessive free radicals with peels and juices of citrus fruits: Grapefruit, lemon, lime and orange, Food and Chemical Toxicology, 48, 99, 10.1016/j.fct.2009.09.022

Habauzit, 2011, Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism, Bone, 49, 1108, 10.1016/j.bone.2011.07.030

Hagenlocher, 2017, Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS-and IgE-mediated activation of human intestinal mast cells, European Journal of Nutrition, 56, 1609, 10.1007/s00394-016-1207-z

Hakim, 2000, Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin, Nutrition and Cancer, 37, 161, 10.1207/S15327914NC372_7

Han, 2010, Isolation and identification of polymethoxyflavones from the hybrid Citrus, Hallabong, Journal of Agricultural and Food Chemistry, 58, 9488, 10.1021/jf102730b

Hayat, 2009, Optimized microwave-assisted extraction of phenolic acids from citrus mandarin peels and evaluation of antioxidant activity in vitro, Separation and Purification Technology, 70, 63, 10.1016/j.seppur.2009.08.012

Hayat, 2010, Liberation and separation of phenolic compounds from citrus mandarin peels by microwave heating and its effect on antioxidant activity, Separation and Purification Technology, 73, 371, 10.1016/j.seppur.2010.04.026

He, 2011, Simultaneous determination of flavanones, hydroxycinnamic acids and alkaloids in citrus fruits by HPLC-DAD–ESI/MS, Food Chemistry, 127, 880, 10.1016/j.foodchem.2010.12.109

Hegazy, 2012, Antioxidant activities of orange peel extracts, World Applied Sciences Journal, 18, 684

Heleno, 2015, Bioactivity of phenolic acids: Metabolites versus parent compounds: A review, Food Chemistry, 173, 501, 10.1016/j.foodchem.2014.10.057

Heo, 2004, Effect of antioxidant flavanone, naringenin, from Citrus junos on neuroprotection, Journal of Agricultural and Food Chemistry, 52, 1520, 10.1021/jf035079g

Hirata, 2009, Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer, Bioorganic & Medicinal Chemistry, 17, 25, 10.1016/j.bmc.2008.11.039

Ho, 2014, Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium), Food and Chemical Toxicology, 71, 176, 10.1016/j.fct.2014.06.014

Ho, 2008, Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels, Journal of Agricultural and Food Chemistry, 56, 7976, 10.1021/jf801434c

Hosni, 2010, Composition of peel essential oils from four selected Tunisian Citrus species: Evidence for the genotypic influence, Food Chemistry, 123, 1098, 10.1016/j.foodchem.2010.05.068

Hou, 2019, Extraction of essential oil from Citrus reticulate Blanco peel and its antibacterial activity against Cutibacterium acnes (formerly Propionibacterium acnes), Heliyon, 5, e02947, 10.1016/j.heliyon.2019.e02947

Huang, 2010, Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel, Food Chemistry, 119, 868, 10.1016/j.foodchem.2009.09.092

Hung, 2018, Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat, Journal of Food and Drug Analysis, 26, 849, 10.1016/j.jfda.2017.08.003

Inoue, 2010, Isolation of hesperidin from peels of thinned Citrus unshiu fruits by microwave-assisted extraction, Food Chemistry, 123, 542, 10.1016/j.foodchem.2010.04.051

Iwase, 2001, Cancer chemopreventive activity of 3, 5, 6, 7, 8, 3′, 4′-heptamethoxyflavone from the peel of citrus plants, Cancer Letters, 163, 7, 10.1016/S0304-3835(00)00691-1

Jeong, 2004, Effect of heat treatment on the antioxidant activity of extracts from citrus peels, Journal of Agricultural and Food Chemistry, 52, 3389, 10.1021/jf049899k

Jomaa, 2012, The cytotoxic effect of essential oil of Syrian Citrus limon peel on human colorectal carcinoma cell line (Lim1863), Middle East Journal of Cancer, 3, 15

Kabra, 2012, Antidiabetic activity of ethanol extract of Citrus medica L. peels in streptozotocin induced diabetic rats, Journal of Pharmacy Research, 5, 1287

Kaderides, 2020, Stability of pomegranate peel polyphenols encapsulated in orange juice industry by-product and their incorporation in cookies, Food Chemistry, 310, 125849, 10.1016/j.foodchem.2019.125849

Kanaze, 2009, The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin, Biomedical Chromatography, 23, 239, 10.1002/bmc.1090

Kang, 2006, Studies on the development of functional powder from citrus peel, Bioresource Technology, 97, 614, 10.1016/j.biortech.2005.03.037

Kang, 2012, Immature Citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice, Biological and Pharmaceutical Bulletin, 35, 223, 10.1248/bpb.35.223

Khan, 2010, Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L.) peel, Food Chemistry, 119, 851, 10.1016/j.foodchem.2009.08.046

Kim, 2011, Determination of the change of flavonoid components as the defence materials of Citrus unshiu Marc. fruit peel against Penicillium digitatum by liquid chromatography coupled with tandem mass spectrometry, Food Chemistry, 128, 49, 10.1016/j.foodchem.2011.02.075

Kim, 2013, Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-both In Vitro and In Vivo in Mice Fed a High-Fat Diet, Evidence-based Complementary and Alternative Medicine, 2013

Kurowska, 2004, Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia, Journal of Agricultural and Food Chemistry, 52, 2879, 10.1021/jf035354z

Kurup, 2018, Citrus peels prevent cancer, Phytomedicine, 50, 231, 10.1016/j.phymed.2017.08.011

Lagha-Benamrouche, 2013, Phenolic contents and antioxidant activity of orange varieties (Citrus sinensis L. and Citrus aurantium L.) cultivated in Algeria: Peels and leaves, Industrial Crops and Products, 50, 723, 10.1016/j.indcrop.2013.07.048

Lai, 2007, Inhibitory effect of citrus 5-hydroxy-3, 6, 7, 8, 3′, 4′-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice, Carcinogenesis, 28, 2581, 10.1093/carcin/bgm231

Lai, 2013, Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids, Molecular Nutrition & Food Research, 57, 551, 10.1002/mnfr.201200606

Lai, 2013, Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors, Food & Function, 4, 944, 10.1039/c3fo60037h

Lai, 2011, Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice, Molecular Nutrition & Food Research, 55, 278, 10.1002/mnfr.201000224

Lee, 2016, Aqueous extraction of Citrus unshiu peel induces proangiogenic effects through the FAK and ERK1/2 signaling pathway in human umbilical vein endothelial cells, Journal of Medicinal Food, 19, 569, 10.1089/jmf.2015.3584

Lee, 2011, Effects of a Citrus depressa Hayata (shiikuwasa) extract on obesity in high-fat diet-induced obese mice, Phytomedicine, 18, 648, 10.1016/j.phymed.2010.11.005

Li, 2007, Identification of flavanones from peel of Citrus changshan-huyou YB Chang, by HPLC–MS and NMR, European Food Research and Technology, 225, 777, 10.1007/s00217-006-0481-z

Li, 2019, Determination of citrus juice coumarins, furanocoumarins and methoxylated flavones using solid phase extraction and HPLC with photodiode array and fluorescence detection, Food Chemistry, 271, 29, 10.1016/j.foodchem.2018.07.130

Li, 2006, Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel, Journal of Agricultural and Food Chemistry, 54, 4176, 10.1021/jf060234n

Li, 2009, Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones, Journal of Functional Foods, 1, 2, 10.1016/j.jff.2008.09.003

Li, 2012, Pressurised liquid extraction combining LC–DAD–ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulata ‘Chachi’(Guangchenpi), Food Chemistry, 130, 1044, 10.1016/j.foodchem.2011.07.129

Lim, 2016, Protective effects of a polymethoxy flavonoids-rich Citrus aurantium peel extract on liver fibrosis induced by bile duct ligation in mice, Asian Pacific journal of Tropical Medicine, 9, 1158, 10.1016/j.apjtm.2016.10.009

Liu, 2013, Simultaneous determination of six bioactive flavonoids in Citri Reticulatae Pericarpium by rapid resolution liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry, Food Chemistry, 141, 3977, 10.1016/j.foodchem.2013.06.077

Liu, 2012, Preparative separation of polymethoxylated flavones from Ponkan (Citrus reticulata Blanco cv. Ponkan) peel by high-speed countercurrent chromatography and their antifungal activities against Aspergillus niger, European Food Research and Technology, 235, 631, 10.1007/s00217-012-1793-9

Londoño-Londoño, 2010, Clean recovery of antioxidant flavonoids from citrus peel: Optimizing an aqueous ultrasound-assisted extraction method, Food Chemistry, 119, 81, 10.1016/j.foodchem.2009.05.075

Lu, 2020, Evaluation of oral bioaccessibility of aged citrus peel extract encapsulated in different lipid based systems: A comparison study using different in vitro digestion models, Journal of Agricultural and Food Chemistry, 68, 97, 10.1021/acs.jafc.9b05372

Lu, 2006, Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China, Plant Foods for Human Nutrition, 61, 55, 10.1007/s11130-006-0014-8

Ma, 2008, Effect of ultrasonic treatment on the total phenolic and antioxidant activity of extracts from citrus peel, Journal of Food Science, 73, T115, 10.1111/j.1750-3841.2008.00908.x

Ma, 2009, Simultaneous extraction of phenolic compounds of citrus peel extracts: Effect of ultrasound, Ultrasonics Sonochemistry, 16, 57, 10.1016/j.ultsonch.2008.04.012

Ma, 2008, Phenolic compounds and antioxidant activity of extracts from ultrasonic treatment of Satsuma mandarin (Citrus unshiu Marc.) peels, Journal of Agricultural and Food Chemistry, 56, 5682, 10.1021/jf072474o

Mahato, 2019, Citrus essential oils: Extraction, authentication and application in food preservation, Critical Reviews in Food Science and Nutrition, 59, 611, 10.1080/10408398.2017.1384716

Mahato, 2018, Citrus waste derived nutra-/pharmaceuticals for health benefits: Current trends and future perspectives, Journal of Functional Foods, 40, 307, 10.1016/j.jff.2017.11.015

Manach, 2004, Pharmacokinetics and metabolism of dietary flavonoids in humans, Free Radical Research, 38, 771, 10.1080/10715760410001727858

Mandalari, 2006, Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction, Journal of Agricultural and Food Chemistry, 54, 197, 10.1021/jf051847n

Manthey, 2008, Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3′, 4′, 3, 5, 6, 7, 8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays, Journal of Agricultural and Food Chemistry, 56, 9399, 10.1021/jf801222h

Manthey, 2001, Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses, Journal of Agricultural and Food Chemistry, 49, 3268, 10.1021/jf010011r

Manthey, 2002, Antiproliferative activities of citrus flavonoids against six human cancer cell lines, Journal of Agricultural and Food Chemistry, 50, 5837, 10.1021/jf020121d

Marzouk, 2013, Characterization of bioactive compounds in Tunisian bitter orange (Citrus aurantium L.) peel and juice and determination of their antioxidant activities, BioMed Research International, 2013

Matsuzaki, 2008, Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus, European Journal of Pharmacology, 578, 194, 10.1016/j.ejphar.2007.09.028

Maurya, 2018, The essential oil from Citrus limetta Risso peels alleviates skin inflammation: In-vitro and in-vivo study, Journal of Ethnopharmacology, 212, 86, 10.1016/j.jep.2017.10.018

McKay, 2015, Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults, Food Chemistry, 168, 233, 10.1016/j.foodchem.2014.07.062

Miller, 2007, Inhibition of oral carcinogenesis by citrus flavonoids, Nutrition and Cancer, 60, 69, 10.1080/01635580701616163

Naim, 2012, Comparative study of antidiabetic activity of hexane-extract of lemon peel (Limon citrus) and glimepiride in alloxan-induced diabetic rats, Bangladesh Pharmaceutical Journal, 15, 131, 10.3329/bpj.v15i2.12577

Nayak, 2015, Comparison of microwave, ultrasound and accelerated-assisted solvent extraction for recovery of polyphenols from Citrus sinensis peels, Food Chemistry, 187, 507, 10.1016/j.foodchem.2015.04.081

Negro, 2016, Citrus waste as feedstock for bio-based products recovery: Review on limonene case study and energy valorization, Bioresource Technology, 214, 806, 10.1016/j.biortech.2016.05.006

Nielsen, 2006, Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: A randomized, double-blind, crossover trial, The Journal of Nutrition, 136, 404, 10.1093/jn/136.2.404

Onoue, 2011, Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability, Journal of Pharmaceutical Sciences, 100, 3793, 10.1002/jps.22585

Ortuño, 2010, Matrix effects on the bioavailability of resveratrol in humans, Food Chemistry, 120, 1123, 10.1016/j.foodchem.2009.11.032

Ozturk, 2018, Extraction of polyphenolic antioxidants from orange peel waste using deep eutectic solvents, Separation and Purification Technology, 206, 1, 10.1016/j.seppur.2018.05.052

Park, 2013, Narirutin fraction from citrus peels attenuates alcoholic liver disease in mice, Food and Chemical Toxicology, 55, 637, 10.1016/j.fct.2013.01.060

Park, 2012, Effect of oral administration of water-soluble extract from citrus peel (Citrus unshiu) on suppressing alcohol-induced fatty liver in rats, Food Chemistry, 130, 598, 10.1016/j.foodchem.2011.07.081

Parmar, 2008, Antiperoxidative, antithyroidal, antihyperglycemic and cardioprotective role of Citrus sinensis peel extract in male mice, Phytotherapy Research, 22, 791, 10.1002/ptr.2367

Peng, 2018, Effect of citrus peel on phenolic compounds, organic acids and antioxidant activity of soy sauce, LWT-Food Science and Technolofy, 90, 627, 10.1016/j.lwt.2018.01.008

Rafiq, 2018, Citrus peel as a source of functional ingredient: A review, Journal of the Saudi Society of Agricultural Sciences, 17, 351, 10.1016/j.jssas.2016.07.006

Ramful, 2010, Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: Potential prophylactic ingredients for functional foods application, Toxicology, 278, 75, 10.1016/j.tox.2010.01.012

Ramírez-Pelayo, 2019, Coumarins from the peel of citrus grown in Colombia: Composition, elicitation and antifungal activity, Heliyon, 5, e01937, 10.1016/j.heliyon.2019.e01937

Safdar, 2017, Extraction and quantification of polyphenols from kinnow (Citrus reticulate L.) peel using ultrasound and maceration techniques, Journal of Food and Drug Analysis, 25, 488, 10.1016/j.jfda.2016.07.010

Santhakumar, 2018, Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis, Food and Chemical Toxicology, 113, 49, 10.1016/j.fct.2018.01.022

Satari, 2018, Citrus processing wastes: Environmental impacts, recent advances, and future perspectives in total valorization, Resources, Conservation and Recycling, 129, 153, 10.1016/j.resconrec.2017.10.032

Sathiyabama, 2018, Evidence of insulin-dependent signalling mechanisms produced by Citrus sinensis (L.) Osbeck fruit peel in an insulin resistant diabetic animal model, Food and chemical toxicology, 116, 86, 10.1016/j.fct.2018.03.050

Sawalha, 2009, Quantification of main phenolic compounds in sweet and bitter orange peel using CE–MS/MS, Food Chemistry, 116, 567, 10.1016/j.foodchem.2009.03.003

Scoma, 2011, A physicochemical–biotechnological approach for an integrated valorization of olive mill wastewater, Bioresource Technology, 102, 10273, 10.1016/j.biortech.2011.08.080

Sharma, 2019, Extraction, characterization and biological activity of citrus flavonoids, Reviews in Chemical Engineering, 35, 265, 10.1515/revce-2017-0027

Shetty, 2016, Antimicrobial effects of Citrus sinensis peel extracts against dental caries bacteria: An in vitro study, Journal of Clinical and Experimental Dentistry, 8, e71

Siddique, 2016, Hesperidin, a citrus flavonoid, increases the bioavailability of micronutrients of Gallus domesticus (chicken) eggshell: In vitro study, Chemical Speciation & Bioavailability, 28, 88, 10.1080/09542299.2016.1182446

Silva, 2018, Polymethoxylated flavones from orange peels inhibit cell proliferation in a 3D cell model of human colorectal cancer, Nutrition and Cancer, 70, 257, 10.1080/01635581.2018.1412473

Singh, 2017, Phenolic composition and antioxidant potential of grain legume seeds: A review, Food Research International, 101, 1, 10.1016/j.foodres.2017.09.026

Singh, 2018, Insights into the phenolic compounds present in jambolan (Syzygium cumini) along with their health-promoting effects, International Journal of Food Science & Technology, 53, 2431, 10.1111/ijfs.13841

Singh, 2018, Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: A review, Food Chemistry, 261, 75, 10.1016/j.foodchem.2018.04.039

Singh, 2016, In vitro antioxidant and antimicrobial properties of jambolan (Syzygium cumini) fruit polyphenols, LWT-Food Science and Technology, 65, 1025, 10.1016/j.lwt.2015.09.038

Soquetta, 2019, Ultrasound extraction of bioactive compounds from Citrus reticulata peel using electrolyzed water, Journal of Food Processing and Preservation, 43, e14236, 10.1111/jfpp.14236

Sridharan, 2016, Regulation of urinary crystal inhibiting proteins and inflammatory genes by lemon peel extract and formulated citrus bioflavonoids on ethylene glycol induced urolithic rats, Food and Chemical Toxicology, 94, 75, 10.1016/j.fct.2016.05.013

Thériault, 2006, Antioxidant, antiradical and antimutagenic activities of phenolic compounds present in maple products, Food Chemistry, 98, 490, 10.1016/j.foodchem.2005.05.079

Trabelsi, 2016, Supercritical extraction from Citrus aurantium amara peels using CO2 with ethanol as co-solvent, The Journal of Supercritical Fluids, 117, 33, 10.1016/j.supflu.2016.07.003

Tsutsumi, 2014, Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle, Nutrition & Metabolism, 11, 32, 10.1186/1743-7075-11-32

Wang, 2007, Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques, Journal of Pharmaceutical and Biomedical Analysis, 44, 63, 10.1016/j.jpba.2007.01.048

Wang, 2014, Anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others, BioMed Research International, 2014, 10.1155/2014/453972

Wang, 2008, The flavonoid, carotenoid and pectin content in peels of citrus cultivated in Taiwan, Food Chemistry, 106, 277, 10.1016/j.foodchem.2007.05.086

Xiao, 2009, Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis, Molecular Nutrition & Food Research, 53, 398, 10.1002/mnfr.200800057

Xing, 2017, Fast separation and sensitive quantitation of polymethoxylated flavonoids in the peels of citrus using UPLC-Q-TOF-MS, Journal of Agricultural and Food Chemistry, 65, 2615, 10.1021/acs.jafc.6b05821

Zanotti, 2015, Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism, Food & Function, 6, 13, 10.1039/C4FO00670D

Zhang, 2017, Preparative separation of six coumarins from the pummelo (Citrus maxima (Burm.) Merr. Cv. Shatian Yu) peel by high-speed countercurrent chromatography, Journal of Liquid Chromatography & Related Technologies, 40, 991, 10.1080/10826076.2017.1399139