Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma

Blood - Tập 123 Số 11 - Trang 1681-1690 - 2014
Alyssa Bouska1, Timothy W. McKeithan1, Karen Deffenbacher1, Cynthia M. Lachel1, George W. Wright2, Javeed Iqbal1, Lynette M. Smith3, Wei Zhang1, Can Küçük1, Andrea Rinaldi4, Francesco Bertoni5,4, Jude Fitzgibbon6, Kai Fu1, Dennis D. Weisenburger7, Timothy C. Greiner1, Bhavana J. Davé8, Randy D. Gascoyne9, Andreas Rosenwald10, German Ott11, Elı́as Campo12, Lisa M. Rimsza13, Jan Delabie14, Elaine S. Jaffe15, Rita M. Braziel16, Joseph M. Connors17, Louis M. Staudt18, Wing C. Chan1
1Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
2Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD
3College of Public Health Biostatistics, University of Nebraska Medical Center, Omaha, NE;
4Lymphoma and Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland
5Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
6Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
7Department of Pathology, City of Hope National Medical Center, Duarte, CA
8Center for Human Genetics, University of Nebraska Medical Center, Omaha, NE;
9Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
10Pathology, University of Würzburg, Würzburg, Germany
11Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;
12Hematopathology Unit, Hospital Clinic, Barcelona, Spain
13Department of Pathology, University of Arizona, Tucson, AZ
14Department of Pathology, University of Toronto, Toronto, ON, Canada
15Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD
16Oregon Health Sciences Center, Portland, OR
17Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada; and
18Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

Tóm tắt

Key PointsChromosome copy-number alterations that may affect immune surveillance and the NF-κB and p53 pathways are more frequent in tFL than FL. Abnormalities involving chromosomes 6 and X are predictive of overall survival in FL.

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