PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

Nature Medicine - Tập 7 Số 1 - Trang 53-58 - 2001
Giulia Chinetti1, Sophie Lestavel1, Virginie Bocher1, Alan T. Remaley2, Bernadette Neve1, Inés Pineda‐Torra1, Elisabeth Teissier1, Anne Minnich3, Michael Jaye3, Nicolas Duverger4, H Bryan Brewer2, Jean‐Charles Fruchart1, Véronique Clavey1, Bart Staels1
1Institut Pasteur and U325 INSERM and Université de Lille 2, Lille, France.
2National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, USA
3Aventis Pharma, Collegeville, USA
4Core Genomics and Cardiovascular Departments, Aventis Pharma, Vitry sur Seine, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Pineda Torra, I., Gervois, P. & Staels, B. Peroxisome proliferator-activated receptor α in metabolic disease, inflammation, atherosclerosis and aging. Curr. Opin. Lipidol. 10, 151–159 (1999).

Brun, R.P. et al. Differential activation of adipogenesis by multiple PPAR- isoforms. Genes Dev. 10, 974–984 (1996).

Jiang, C., Ting, A.T. & Seed, B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82–86 (1998).

Ricote, M., Li, A.C., Willsson, T.M., Kelly, C.J. & Glass, C.K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79–82 (1998).

Chinetti, G. et al. Activation of peroxisome proliferator-activated receptorsγ and γ induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 273, 25573–25580 (1998).

Tontonoz, P., Nagy, L., Alvarez, J., Thomazy, V. & Evans, R. PPAR-γ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241–252 (1998).

Chinetti, G. et al. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation 101, 2411–2417 (2000).

Brooks-Wilson, A. et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genet. 22, 336–345 (1999).

Lawn, R.M. et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J. Clin. Invest. 104, R25–R31 (1999).

Bodzioch, M. et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nature Genet. 22, 347–351 (1999).

Rust, S. et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nature Genet. 22, 352–355 (1999).

Hobbs, H.H. & Rader, D.J. ABC1: connecting yellow tonsils, neuropathy and very low HDL. J. Clin. Invest. 104, 1015–1007 (1999).

Wolffenbuttel, B.H., Gomis, R., Squatrito, S., Jones, N.P. & Patwardhan, R.M. Addition of low-dose rosiglitazone to sulphonylurea therapy glycaemic control in Type 2 diabetic patients. Diabet. Med. 17, 40–47 (2000).

Vu-Dac, N. et al. The nuclear receptor peroxisome proliferator-activated Receptors α and Rev-erb γ mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J. Biol. Chem. 273, 25713–25720 (1998).

Janowski, B.A., Willy, P.J., Devi, T.R., Falck, J.R. & Mangelsdorf, D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR-α. Nature 383, 728–731 (1996).

Costet, P., Luo, Y., Wang, N. & Tall, A.R. Sterol-dependent transactivation of the human ABC1 promoter by LXR-/RXR. J. Biol. Chem. 275, 28240–28245 (2000).

Frick, M.H. et al. Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Circulation 96, 2137–2143 (1997).

Ericsson, C. et al. Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet 347, 849–53 (1996).

Law, R. et al. Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia. J. Clin. Invest. 98, 1897–1905 (1996).

Rubins, H.B. et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 341, 410–418 (1999).

Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801–809 (1993).

Willson, T.M., Brown, P.J., Sternbach, D.D. & Henke, B.R. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43, 527–550 (2000).

Forman, B.M., Ruan, B., Chen, J., Schroepfer, G.J. Jr. & Evans, R.M. The orphan nuclear receptor LXR-α is positively and negatively regulated by distinct products of mevalonate metabolism. Proc. Natl. Acad. Sci. USA 94, 10588–10593 (1997).

Venkateswaran, A. et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR-α. Proc. Natl. Acad. Sci. USA 97, 12097–12102 (2000).

Forte, T.M. & McCall, M.R. The role of apolipoprotein A-I-containing lipoproteins in atherosclerosis. Curr. Opin. Lipidol. 5, 354–364 (1994).

Becq, F. et al. ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes. J. Biol. Chem. 272, 2695–2699 (1997).

Hamon, Y. et al. Interleukin-1β secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1. Blood 90, 2911–2915 (1997).

Remaley, A.T. et al. Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred. Proc. Natl. Acad. Sci. USA 96, 12685–12690 (1999).

Marx, N., Sukhova, G., Murphy, C., Libby, P. & Plutzky, J. Macrophages in human atheroma contain PPAR-γ: differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPAR-γ) expression and reduction of MMP-9 activity through PPAR-gamma activation in mononuclear phagocytes in vitro. Am. J. Pathol. 153, 17–23 (1998).

Tobin, K.A. et al. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α. Mol. Endocrinol. 14, 741–752 (2000).

Ji, Y. et al. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J. Biol. Chem. 272, 20982–20985 (1997).

Barman Balfour, J.A. & Plosker, G.L. Rosiglitazone. Drugs 57, 921–930 (1999).

Staels, B. et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98, 2088–2093 (1998).

Vu-Dac, N. et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J. Clin. Invest. 96, 741–750 (1995).

Delerive, P. et al. Oxidized phospholipids activate PPAR-α in a phospholipase A2-dependant manner. FEBS Lett. 471, 34–38 (2000).

Basu, S.K., Goldstein, J.L., Anderson, G.W. & Brown, M.S. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc. Natl. Acad. Sci. USA 73, 3178–3182 (1976).

Kritharides, L., Christian, A., Stoudt, G., Morel, D. & Rothblat, G.H. Cholesterol metabolism and efflux in human THP-1 macrophages. Arterioscler. Throm. Vasc. Biol. 18, 1589–1599 (1998).

Folch, J., Lees, M. & Sloane Stanley, G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497–5 (1957).