Role of MicroRNAs in Plant and Animal Development

American Association for the Advancement of Science (AAAS) - Tập 301 Số 5631 - Trang 336-338 - 2003
James C. Carrington1, Victor Ambros1
1Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA. Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.

Tóm tắt

Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.

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We acknowledge support from NSF (MCB-0209836 to J.C.C.) and NIH (GM34028 to V.A. and AI43288 to J.C.C.).

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American Association for the Advancement of Science (AAAS)

Tập 301 Số 5631

336-338

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