The Real‐World Effect of 12 Months of Romosozumab Treatment on Patients With Osteoporosis With a High Risk of Fracture and Factors Predicting the Rate of Bone Mass Increase: A Multicenter Retrospective Study

JBMR Plus - Tập 6 Số 7 - 2022
Hiroyuki Inose1, Akane Ariga2, Takayuki Motoyoshi2, Kazuyuki Fukushima2, Shoji Tomizawa3, Tsuyoshi Kato4, Kunihiko Takahashi5, Toshitaka Yoshii6, Atsushi Okawa6
1Department of Orthopedic and Trauma Research, Tokyo Medical and Dental University, Tokyo, Japan
2Department of Orthopedics, Saku Central Hospital Advanced Care Center, Nagano, Japan
3Department of Orthopedics, Tokyo Bay Urayasu Ichikawa Medical Center, Chiba, Japan
4Department of Orthopaedics, Ome Municipal General Hospital, Tokyo, Japan
5Department of Biostatistics, M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan
6Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Tóm tắt

ABSTRACTExcluding clinical trials, there is limited evidence on the effect of 12 months of romosozumab treatment on bone mineral density (BMD) increase in real‐world clinical practice because its use has only been approved recently. Thus, this study aimed to investigate the real‐world effect of 12 months of romosozumab treatment on BMD increase and identify factors that predict the rate of BMD increase after 12 months of romosozumab treatment. We retrospectively investigated 106 patients who completed a 12‐month romosozumab treatment for osteoporosis with a high risk of fractures at four hospitals from March 2020 to March 2022. The univariate and multiple regression analyses were performed to analyze the concurrent effects of various factors on the BMD increase after the 12‐month romosozumab treatment. After 1 year of treatment, the lumbar spine BMD increased by 14.6%, and femoral neck BMD increased by 5.1%. Univariate regression analysis found that male sex, high tartrate‐resistant acid phosphatase 5b (TRACP‐5b) value before romosozumab administration, absence of osteoporosis medications before romosozumab administration, and low baseline lumbar spine BMD were associated with the extent of lumbar spine BMD increase. Moreover, stepwise multiple regression analysis found that the TRACP‐5b value before romosozumab administration was a significant predictor of the rate of lumbar spine BMD increase after 1 year of romosozumab administration. In conclusion, our results demonstrated the effectiveness of the 12‐month romosozumab treatment for osteoporosis with a high risk of fractures and the TRACP‐5b value before romosozumab administration was a significant predictor of the rate of lumbar spine BMD increase after 1 year of romosozumab administration. Our findings could help establish more efficient treatment strategies for patients with osteoporosis at a high risk of fracture. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

Từ khóa


Tài liệu tham khảo

10.5152/eurjrheum.2016.048

10.1007/s00198-004-1762-7

10.3390/jcm10245961

10.1007/s11136-020-02629-9

10.1016/j.jos.2020.04.015

Bodenner D, 2007, Teriparatide in the management of osteoporosis, Clin Interv Aging, 2, 499

10.1001/archinte.165.15.1762

10.1038/nm.3074

10.1056/NEJMoa1607948

10.1016/j.bone.2017.07.005

10.1056/NEJMoa1305224

10.1007/s00198-021-05925-3

10.1016/j.jbspin.2021.105219

10.1016/j.bonr.2021.101068

10.3349/ymj.2021.62.9.829

10.1007/s00774-013-0447-8

10.1007/s00198-005-1916-2

10.1097/BRS.0000000000001995

Halleen JM, 2006, Tartrate‐resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption, Clin Lab, 52, 499

10.1002/9781118548387

10.1093/ejcts/ezy403

10.1007/s00774-019-01057-1

10.1002/jbmr.3735

10.1210/jc.2009-1703

Thông tin
Thông tin xuất bản

JBMR Plus

Tập 6 Số 7

Thông tin tác giả