Temporal Phases in Apoptosis Defined by the Actions of Src Homology 2 Domains, Ceramide, Bcl-2, Interleukin-1β Converting Enzyme Family Proteases, and a Dense Membrane Fraction

Chittenden, 1995, Induction of apoptosis by the Bcl-2 homologue Bak, Nature (Lond), 374, 733, 10.1038/374733a0

Cohen, 1995, Modular binding domains in signal transduction proteins, Cell, 80, 237, 10.1016/0092-8674(95)90406-9

Cosulich, 1996, Bcl-2 regulates activation of apoptotic proteases in a cell-free system, Curr Biol, 6, 997, 10.1016/S0960-9822(02)00644-9

Couture, 1996, Regulation of the Lck SH2 domain by tyrosine phosphorylation, J Biol Chem, 271, 24880, 10.1074/jbc.271.40.24880

Darmon, 1995, Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B, Nature (Lond), 377, 446, 10.1038/377446a0

Duan, 1996, ICE-LAP3, a novel mammalian homologue of the Caenorhabditis eleganscell death protein Ced-3, is activated during Fas- and tumor necrosis factor-induced apoptosis, J Biol Chem, 271, 1621, 10.1074/jbc.271.3.1621

Ellis, 1991, Mechanisms and functions of cell death, Annu Rev Cell Biol, 7, 663, 10.1146/annurev.cb.07.110191.003311

Evans, 1997, Crk is required for apoptosis in Xenopusegg extracts, EMBO (Eur Mol Biol Organ) J, 16, 230, 10.1093/emboj/16.2.230

Farrow, 1995, Cloning of a bcl-2homologue by interaction with adenovirus E1B 19K, Nature (Lond), 374, 731, 10.1038/374731a0

Fath, 1994, Cloning of a Grb2 isoform with apoptotic properties, Science (Lond), 264, 971

Fernandes-Alnemri, 1994, CPP32, a novel human apoptotic protein with homology to Caenorhabditis eleganscell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme, J Biol Chem, 269, 30761, 10.1016/S0021-9258(18)47344-9

Fernandes-Alnemri, 1995, Mch2, a new member of the apoptotic Ced-3/ICEcysteine protease gene family, Cancer Res, 55, 2737

Fernandes-Alnemri, 1995, Mch3, a novel human apoptotic cysteine protease highly related to CPP32, Cancer Res, 55, 6045

Frorath, 1992, Production of recombinant rat interleukin-6 in Escherichia coliusing a novel highly efficient expression vector pGEX-3T, Biotechniques, 12, 558

Hengartner, 1994, C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2., Cell, 76, 665, 10.1016/0092-8674(94)90506-1

Kaufmann, 1993, Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis, Cancer Res, 53, 3976

Kiefer, 1995, Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak, Nature (Lond), 374, 736, 10.1038/374736a0

Kluck, 1997, The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis, Science (Wash DC), 275, 1132, 10.1126/science.275.5303.1132

Lazebnik, 1993, Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis, J Cell Biol, 123, 7, 10.1083/jcb.123.1.7

Lazebnik, 1994, Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE, Nature (Lond), 371, 346, 10.1038/371346a0

Lippke, 1996, Identification and characterization of CPP34/Mch2 homolog 1, a novel cysteine protease similar to CPP32, J Biol Chem, 271, 1825, 10.1074/jbc.271.4.1825

Liu, 1995, Compartmentalized production of ceramide at the cell surface, J Biol Chem, 270, 27179, 10.1074/jbc.270.45.27179

Liu, 1996, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9

Martin, 1995, Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis, EMBO (Eur Mol Biol Organ) J, 14, 5191, 10.1002/j.1460-2075.1995.tb00203.x

Martin, 1995, Proteolysis of fodrin (non-erythroid spectrin) during apoptosis, J Biol Chem, 270, 6425, 10.1074/jbc.270.12.6425

Miura, 1993, Induction of apoptosis is fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3., Cell, 75, 653, 10.1016/0092-8674(93)90486-A

Mustelin, 1989, Rapid activation of the T-cell tyrosine protein kinase pp56lckby the CD45 phosphotyrosine phosphatase, Proc Natl Acad Sci USA, 86, 6302, 10.1073/pnas.86.16.6302

Newmeyer, 1991, Egg extracts for nuclear import and nuclear assembly reactions, Methods Cell Biol, 36, 607, 10.1016/S0091-679X(08)60299-X

Newmeyer, 1994, Cell-free apoptosis in Xenopusegg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria, Cell, 79, 353, 10.1016/0092-8674(94)90203-8

Nicholson, 1995, Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis, Nature (Lond), 376, 37, 10.1038/376037a0

Nosseri, 1994, Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis, Exp Cell Res, 212, 367, 10.1006/excr.1994.1156

Nuñez, 1994, The Bcl-2 family of proteins: regulators of cell death and survival, Trends Cell Biol, 4, 399, 10.1016/0962-8924(94)90053-1

Oberhammer, 1994, Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase, J Cell Biol, 126, 827, 10.1083/jcb.126.4.827

Osborne, 1994, Essential genes that regulate apoptosis, Trends Cell Biol, 4, 394, 10.1016/0962-8924(94)90052-3

Pascal, 1994, Nuclear magnetic resonance structure of an SH2 domain of phosholipase C-γ1 complexed with a high affinity binding peptide, Cell, 77, 461, 10.1016/0092-8674(94)90160-0

Pawson, 1995, Protein modules and signalling networks, Nature (Lond), 373, 573, 10.1038/373573a0

Reed, 1994, Bcl-2 and the regulation of programmed cell death, J Cell Biol, 124, 1, 10.1083/jcb.124.1.1

Sato, 1994, Interactions among members of the Bcl-2 protein family analyzed with a yeast twohybrid system, Proc Natl Acad Sci USA, 91, 9238, 10.1073/pnas.91.20.9238

Schlegel, 1996, CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis, J Biol Chem, 271, 1841, 10.1074/jbc.271.4.1841

Shimizu, 1991, Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion, Biochem Biophys Res Commun, 169, 1172, 10.1016/0006-291X(90)92019-V

Songyang, 1993, SH2 domains recognize specific phosphopeptide sequences, Cell, 72, 767, 10.1016/0092-8674(93)90404-E

Steller, 1995, Mechanisms and genes of cellular suicide, Science (Wash DC), 267, 1445, 10.1126/science.7878463

Tewari, 1995, Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase, Cell, 81, 801, 10.1016/0092-8674(95)90541-3

Vaux, 1992, Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2., Science (Wash DC), 258, 1955, 10.1126/science.1470921

Vaux, 1994, An evolutionary perspective on apoptosis, Cell, 76, 777, 10.1016/0092-8674(94)90350-6

Wyllie, 1980, Cell death: the significance of apoptosis, Int Rev Cytol, 68, 251, 10.1016/S0074-7696(08)62312-8

Yang, 1995, Bad, a heterodimeric partner for Bcl-xland Bcl-2, displaces Bax and promotes cell death, Cell, 80, 285, 10.1016/0092-8674(95)90411-5

Yang, 1997, Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science (Wash DC), 275, 1129, 10.1126/science.275.5303.1129

Yin, 1994, BH1 and BH2 domains of Bcl-2 are required for inhibitio nof apoptosis and heterodimerization with Bax, Nature (Lond), 369, 321, 10.1038/369321a0

Yuan, 1993, The C. elegans cell death gene ced-3encodes a protein similar to mammalian interleukin-1-β-converting enzyme, Cell, 75, 641, 10.1016/0092-8674(93)90485-9