A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

Gordon, 2003, Alternative activation of macrophages., Nat Rev Immunol, 3, 23, 10.1038/nri978 Gordon, 2005, Monocyte and macrophage heterogeneity., Nat Rev Immunol, 5, 953, 10.1038/nri1733 Cohn, 1978, Activation of mononuclear phagocytes: fact, fancy, and future., J Immunol, 121, 813, 10.4049/jimmunol.121.3.813 North, 1978, The concept of the activated macrophage., J Immunol, 121, 806, 10.4049/jimmunol.121.3.806 Mosser, 2003, The many faces of macrophage activation., J Leukoc Biol, 73, 209, 10.1189/jlb.0602325 Mordue, 2003, A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis., J Leukoc Biol, 74, 1015, 10.1189/jlb.0403164 Gordon, 2003, Macrophages and the immune response., Fundamental Immunology, 481 Dockrell, 2006, Regulation of phagocyte lifespan in the lung during bacterial infection., J Leukoc Biol, 79, 904, 10.1189/jlb.1005555 Kinne, 2000, Macrophages in rheumatoid arthritis., Arthritis Res, 2, 189, 10.1186/ar86 Bresnihan, 1999, Pathogenesis of joint damage in rheumatoid arthritis., J Rheumatol, 26, 717 Foster, 1999, Lupus nephritis: update on pathogenesis and disease mechanisms., Semin Nephrol, 19, 173 Ren, 2003, Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus., Arthritis Rheum, 48, 2888, 10.1002/art.11237 Grip, 2003, Macrophages in inflammatory bowel disease., Curr Drug Targets Inflamm Allergy, 2, 155, 10.2174/1568010033484179 Swirski, 2007, Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata., J Clin Invest, 117, 195, 10.1172/JCI29950 Bobryshev, 2006, Monocyte recruitment and foam cell formation in atherosclerosis., Micron, 37, 208, 10.1016/j.micron.2005.10.007 Wang, 2006, Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation., J Clin Invest, 116, 2105, 10.1172/JCI27180 Dragun, 2000, Ischemia-reperfusion injury in renal transplantation is independent of the immunologic background., Kidney Int, 58, 2166, 10.1111/j.1523-1755.2000.00390.x Gueler, 2007, Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages., Am J Pathol, 170, 1192, 10.2353/ajpath.2007.060782 Zissel, 2007, Sarcoidosis-immunopathogenetic concepts., Semin Respir Crit Care Med, 28, 3, 10.1055/s-2007-970329 Jose, 2003, Blockade of macrophage migration inhibitory factor does not prevent acute renal allograft rejection., Am J Transplant, 3, 1099, 10.1034/j.1600-6143.2003.00188.x Nadeau, 1995, Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1., Proc Natl Acad Sci U S A, 92, 8729, 10.1073/pnas.92.19.8729 Odegaard, 2007, Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance., Nature, 447, 1116, 10.1038/nature05894 Lumeng, 2007, Obesity induces a phenotypic switch in adipose tissue macrophage polarization., J Clin Invest, 117, 175, 10.1172/JCI29881 Nakashima-Matsushita, 1999, Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis., Arthritis Rheum, 42, 1609, 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L Turk, 2002, Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis., Arthritis Rheum, 46, 1947, 10.1002/art.10405 Nagayoshi, 2003, LY309887, antifolate via the folate receptor suppresses murine type II collagen-induced arthritis., Clin Exp Rheumatol, 21, 719 Paulos, 2006, Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis., Arthritis Res Ther, 8, R77, 10.1186/ar1944 Paulos, 2004, Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis., Adv Drug Deliv Rev, 56, 1205, 10.1016/j.addr.2004.01.012 Antohe, 2005, Increased uptake of folate conjugates by activated macrophages in experimental hyperlipemia., Cell Tissue Res, 320, 277, 10.1007/s00441-004-1071-7 Johnston, 1978, Increased superoxide anion production by immunologically activated and chemically elicited macrophages., J Exp Med, 148, 115, 10.1084/jem.148.1.115 Maurer, 1999, Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines., J Natl Cancer Inst, 91, 1138, 10.1093/jnci/91.13.1138 Reddy, 1999, Expression and functional characterization of the beta-isoform of the folate receptor on CD34(+) cells., Blood, 93, 3940, 10.1182/blood.V93.11.3940 Elnakat, 2004, Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy., Adv Drug Deliv Rev, 56, 1067, 10.1016/j.addr.2004.01.001 Antony, 1985, Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells., J Biol Chem, 260, 14911, 10.1016/S0021-9258(18)95679-6 Deutsch, 1989, Role of the membrane-associated folate binding protein (folate receptor) in methotrexate transport by human KB cells., Arch Biochem Biophys, 274, 327, 10.1016/0003-9861(89)90446-3 Reddy, 2004, Preclinical evaluation of (99m)Tc-EC20 for imaging folate receptor-positive tumors., J Nucl Med, 45, 857 Leamon, 2002, Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical., Bioconjug Chem, 13, 1200, 10.1021/bc0200430 Taylor, 2005, Macrophage receptor and immune recognition., Annu Rev Immunol, 23, 901, 10.1146/annurev.immunol.23.021704.115816 Kinne, 2007, Cells of the synovium in rheumatoid arthritis: macrophages., Arthritis Res Ther, 9, 224, 10.1186/ar2333 Akagawa, 2002, Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages., Int J Hematol, 76, 27, 10.1007/BF02982715 Theurl, 2005, The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections., Biometals, 18, 359, 10.1007/s10534-005-3710-1 Weizer-Stern, 2007, Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53., Br J Haematol, 138, 253, 10.1111/j.1365-2141.2007.06638.x Ross, 1999, Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia., Cancer, 85, 348, 10.1002/(SICI)1097-0142(19990115)85:2<348::AID-CNCR12>3.0.CO;2-4