Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents

British Journal of Psychiatry - Tập 177 Số 6 - Trang 499-504 - 2000
Ian Goodyer1, J. Herbert2, Andrea K. Tamplin1, P. M. E. Altham3
1Developmental Psychiatry Section, Department of Psychiatry, Cambridge Clinical School, University of Cambridge, and Lifespan Healthcare Trust, England
2Neuroendocrine Laboratory, Department of Anatomy, University of Cambridge
3Statistical Laboratory, University of Cambridge

Tóm tắt

BackgroundIt is not clear whether cortisol or dehydroepiandrosterone (DHEA) hypersecretion increases the risk for major depression in the presence of undesirable life events.AimsTo determine whether there is a specific pattern of psychoendocrine factors that predicts the onset of major depressive disorder.Method180 adolescents (73 boys, 107 girls) at high risk for psychopathology were assessed for cortisol, DHEA, depressive symptoms, life events and psychiatric disorder at entry and 12 months later.ResultsMajor depression was predicted for both genders by the additive effects of: higher depressive symptoms; personal disappointments and losses only in the month before onset; one or more daily levels of cortisol at 08.00 h or DHEA at 20.00 h greater than the 80th percentile of the daily mean.ConclusionsA subgroup of adolescents may carry a physiological risk for major depression which may be either of genetic and/or earlier psychosocial origin.

Từ khóa


Tài liệu tham khảo

1994, Diagnostic and Statistical Manual of Mental Disorders

10.1001/archpsyc.56.8.726

10.1016/0301-0082(94)90014-0

10.1097/00004583-199509000-00021

10.1111/j.1469-7610.1997.tb01543.x

10.1210/endo-117-6-2505

10.1016/S0039-128X(99)00046-X

10.1001/archpsyc.56.6.527

10.1017/S0033291799008946

10.1016/S0002-7138(09)60602-6

10.1192/bjp.150.1.30

10.1006/pmed.1998.0276

Buss, 1984, Temperament: Early Developing Personality Traits

Goodyer, 1995, The Depressed Child and Adolescent: Developmental and Clinical Perspectives, 171

10.1016/0165-0327(91)90001-9

10.1017/S0033291700034644

10.1097/00004583-199704000-00009

10.1192/bjp.176.2.142

10.1097/00004583-199707000-00021

10.1177/00912709922007903

10.1016/S0272-7358(98)00010-5

10.1007/BF01537611

Reynolds, 1983, National normative and reliability data for the revised children's manifest anxiety scale, School Psychology Review, 12, 324, 10.1080/02796015.1983.12085047

10.1515/9781400876136

10.1097/00006842-199609000-00007

10.1016/0165-0327(83)90022-8

Thông tin
Thông tin xuất bản

British Journal of Psychiatry

Tập 177 Số 6

499-504

Thông tin tác giả