Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (acute lymphoblastic leukemia antigen p 24)

FEBS Letters - Tập 161 - Trang 289-295 - 1983
Claude Boucheix1, Claudine Soria2, Massoud Mirshahi3, Jeannette Soria4, Jean-Yves Perrot3, Noëlle Fournier1, Martine Billard1, Claude Rosenfeld1
1U 253-Inserm Hôpital Paul Brousse, Villejuif 94800, France
2U 150-Inserm, Hôpital Lariboisiere, Paris, France
3Service de Médecine, Interne et Oncologie, Hôtel Dieu, Paris, France
4Laboratoire Central d'Hématologie et de Biochimie, Paris France

Tóm tắt

The leukemia‐associated cell surface antigen p 24 is found on normal platelets as well as on Bernard Soulier syndrome and thrombasthenia type I platelets. ALB6 IgG (a monoclonal antibody against p 24) induces the aggregation of platelets from normal donors but not from thrombasthenia. In contrast, ALB6 Fab inhibits platelet aggregation induced by collagen, ADP, thrombin, ionophore A 23187 and ALB6 IgG. The results suggest that ALB6 interferes with a mechanism common to all aggregation pathways; the possible mechanisms are discussed.

Tài liệu tham khảo

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FEBS Letters

Tập 161

289-295

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