Human CD8+EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK

Aging Cell - Tập 17 Số 1 - 2018
Lauren A. Callender1, Elizabeth C. Carroll1, R. W. Beal2, Emma S. Chambers3, Sussan Nourshargh2, Arne N. Akbar3, Siân M. Henson1
1Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ UK
2Microvascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ UK
3Division of Infection and Immunity, University College London, London WC1E 6JF, UK

Tóm tắt

SummaryCellular senescence is accompanied by a senescence‐associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to this subset and contribute to age‐associated inflammation. We found the CD8+ CD45RA+CD27− EMRA subset to be the most heterogeneous, with a population aligning with the naïve T cells and another with a closer association to the effector memory subset. However, despite the differing processes that give rise to these senescent CD8+ T cells once generated, they both adopt a unique secretory profile with no commonality to any other subset, aligning more closely with senescence than quiescence. Furthermore, we also show that the SASP observed in senescent CD8+ T cells is governed by p38 MAPK signalling.

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Aging Cell

Tập 17 Số 1

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