Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat

Barman, 1979, Picrotoxin- and bicuculline-sensitive inhibition of cardiac vagal reflexes, J. Pharmacol. Exp. Ther., 209, 67 DiMicco, 1987, Evidence for GABAergic inhibition of a hypothalamic sympathoexcitatory mechanism in anesthetized rats, Brain Research, 402, 1, 10.1016/0006-8993(87)91041-9 Jordan, 1988, Hypothalamic inhibition of neurons in the nucleus tractus solitarius of the cat is GABA mediated, J. Physiol. (London), 399, 389, 10.1113/jphysiol.1988.sp017087 DiMicco, 1979, GABA receptor control to parasympathetic out-flow to heart: characterization and brain stem localization, Science, 204, 1106, 10.1126/science.451556 Willette, 1984, Endogenous GABAergic mechanisms in the medulla and the regulation of blood pressure, J. Pharmacol. Exp. Ther., 230, 34 Kubo, 1987, Evidence for the presence of GABAergic and glycine-like systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat, Neurosci. Lett., 74, 331, 10.1016/0304-3940(87)90319-3 Gordon, 1985, Spinal GABA receptors and central cardiovascular control, Brain Research, 328, 165, 10.1016/0006-8993(85)91338-1 Blessing, 1984, Glutamic acid decar☐ylase immunoreactivity is present in perikarya of neurons in nucleus tractus solitarius of rat, Brain Research, 322, 346, 10.1016/0006-8993(84)90131-8 Meeley, 1985, Intrinsic gamma-aminobutyric acid neurons in the nucleus of the solitary tract and the rostral ventrolateral medulla of the rat: an immunocytochemical and biochemical study, Neurosci. Lett., 58, 83, 10.1016/0304-3940(85)90333-7 Lalley, 1980, Inhibition of depressor cardiovascular reflexes by a derivative of gamma-aminobutyric acid (GABA) and by general anesthetics with suspected GABA-mimetic effects, J. Pharmacol. Exp. Ther., 215, 418 Persson, 1981, A hypertensive response to baclofen in the nucleus tractus solitarii in rats, J. Pharm. Pharmacol., 33, 226, 10.1111/j.2042-7158.1981.tb13763.x Bousquet, 1982, Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS, Naunyn-Schmiedeberg's Arch. Pharmacol., 319, 168, 10.1007/BF00503932 Catelli Sved, 1989, Cardiovascular responses elicited by gamma-aminobutyric acid in the nucleus tractus solitarius: evidence for action at the GABAB receptor, Neuropharmacology, 28, 515, 10.1016/0028-3908(89)90088-9 Catelli, 1988, Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat, Eur. J. Pharmacol., 151, 243, 10.1016/0014-2999(88)90804-7 Dutar, 1988, Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties, Neuron, 1, 585, 10.1016/0896-6273(88)90108-0 Talman, 1981, Baroreflex actions of substance P microinjected into the nucleus tractus solitarii in rat: a consequence of local distortion, Brain Research, 220, 402, 10.1016/0006-8993(81)91233-6 Higuchi, 1986, Lowering calcium in the nucleus tractus solitarius causes hypotension and bradycardia, Am. J. Physiol., 250, H226 Lukovic, 1990, Analysis of the cardiovascular changes evoked by microinjection of NaCl into the nucleus tractus solitarii of rats: evidence for Na+/Ca2+ relationship, Neurosci. Lett., 110, 46, 10.1016/0304-3940(90)90785-8 Talman, 1984, Glutamatergic mechanisms in the nucleus tractus solitarius in blood pressure control, 43, 39 Reynolds, 1987, 3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine, 84, 7744 Honore, 1988, Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists, Science, 241, 701, 10.1126/science.2899909 Leone, 1989, Blockade ofnon-N-methyl-d-aspartic acid receptors in the nucleus of the tractus solitarius eliminates aortic baroreflexes, Soc. Neurosci. Abstr., 15, 1178 Lambert, 1989, Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen, Neurosci. Lett., 107, 125, 10.1016/0304-3940(89)90803-3 Kerr, 1987, Phaclofen: a peripheral and central baclofen antagonist, Brain Research, 405, 150, 10.1016/0006-8993(87)90999-1 Bonnano, 1988, Phaclofen antagonizes GABA at autoreceptors regulating release in rat cerebral cortex, Eur. J. Pharmacol., 154, 223, 10.1016/0014-2999(88)90104-5 Wullner, 1989, Phaclofen antagonizes the depressant effect of baclofen on spinal reflex transmission in rats, Brain Research, 496, 341, 10.1016/0006-8993(89)91085-8 Curtis, 1988, Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord, Neurosci. Lett., 92, 97, 10.1016/0304-3940(88)90749-5 Potaschner, 1978, Baclofen: effects on amino acid release, Canad. J. Physiol. Pharmacol., 56, 150, 10.1139/y78-019 Johnston, 1980, Baclofen: stereoselective inhibition of excitant amino-acid release, J. Pharm. Pharmacol., 32, 230, 10.1111/j.2042-7158.1980.tb12902.x Leone, 1989, Isl-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius?, J. Pharmacol. Exp. Ther., 250, 953 Talman, 1989, Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate, Neurosci. Lett., 102, 247, 10.1016/0304-3940(89)90086-4 Davies, 1988, Evidence for a fourth glutamate receptor subtype on rat central neurones in vivo and in vitro?, J. Physiol. (London), 406, 15P Le Galloudec, 1989, Cardiovascular changes induced by the local application of glutamate-related drugs in the rat nucleus tractus solitarii, Brain Research, 503, 322, 10.1016/0006-8993(89)91683-1 Cherkaoui, 1988, Activation of excitatory amino acid receptors within the nucleus tractus solitarius elicits the swallowing motor pattern in anaesthetized rat, J. Physiol. (London), 406, 16P Somogyi, 1989, Evidence for an excitatory amino acid pathway in the brainstem and for its involvement in cardiovascular control, Brain Research, 496, 401, 10.1016/0006-8993(89)91097-4