Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality

Blood - Tập 125 - Trang 1470-1476 - 2015
Ruchika Goel1,2, Paul M. Ness1, Clifford M. Takemoto2, Lakshmanan Krishnamurti3, Karen E. King1, AaronA.R. Tobian1
1Division of Transfusion Medicine, Department of Pathology, Baltimore, MD
2Division of Pediatric Hematology, Johns Hopkins University, Baltimore, MD
3Division of Pediatric Blood and Bone Marrow Transplantation, Emory University School of Medicine, Atlanta, GA

Tóm tắt

Key Points

Platelet transfusions are frequently administered to hospitalized patients with platelet consumptive/destructive disorders such as TTP, HIT, and ITP. Platelet transfusions are associated with higher odds of arterial thrombosis and mortality among TTP and HIT patients.


Tài liệu tham khảo

Nieswandt, 2011, Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke., J Thromb Haemost, 9, 92, 10.1111/j.1538-7836.2011.04361.x Montalescot, 2011, Platelet biology and implications for antiplatelet therapy in atherothrombotic disease., Clin Appl Thromb Hemost, 17, 371, 10.1177/1076029610373366 Angiolillo, 2010, Basic principles of platelet biology and clinical implications., Circ J., 74, 597, 10.1253/circj.CJ-09-0982 Jennings, 2009, Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis., Thromb Haemost, 102, 248 Boudreau, 2014, Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation., Blood, 124, 2173, 10.1182/blood-2014-05-573543 Harkness, 1981, Hazard of platelet transfusion in thrombotic thrombocytopenic purpura., JAMA, 246, 1931, 10.1001/jama.1981.03320170043028 Gottschall, 1981, Thrombotic thrombocytopenic purpura: experience with whole blood exchange transfusion., Semin Thromb Hemost, 7, 25, 10.1055/s-2007-1005066 Ridolfi, 1981, Thrombotic thrombocytopenic purpura. Report of 25 cases and review of the literature., Medicine (Baltimore), 60, 413, 10.1097/00005792-198111000-00003 Babcock, 1976, Heparin-induced immune thrombocytopenia., N Engl J Med, 295, 237, 10.1056/NEJM197607292950501 Cimo, 1979, Heparin-induced thrombocytopenia: association with a platelet aggregating factor and arterial thromboses., Am J Hematol, 6, 125, 10.1002/ajh.2830060204 Weismann, 1958, Arterial embolism occurring during systemic heparin therapy., AMA Arch Surg, 76, 219, 10.1001/archsurg.1958.01280200041005 Hosler, 2003, Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases., Arch Pathol Lab Med, 127, 834, 10.5858/2003-127-834-TTPAHU George, 2014, Syndromes of thrombotic microangiopathy., N Engl J Med, 371, 654, 10.1056/NEJMra1312353 Warkentin, 2010, HIT: more than just heparin., Blood, 115, 1664, 10.1182/blood-2009-12-255877 Warkentin, 2011, HIT paradigms and paradoxes., J Thromb Haemost, 9, 105, 10.1111/j.1538-7836.2011.04322.x Warkentin, 2003, Heparin-induced thrombocytopenia: pathogenesis and management., Br J Haematol, 121, 535, 10.1046/j.1365-2141.2003.04334.x Buchanan, 1977, Use of homologous platelet survival in differential diagnoses of chronic thrombocytopenia in childhood., Pediatrics, 59, 45, 10.1542/peds.59.1.49 Stoll, 1985, Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia., Blood, 65, 584, 10.1182/blood.V65.3.584.584 Carr, 1986, Efficacy of platelet transfusions in immune thrombocytopenia., Am J Med, 80, 1051, 10.1016/0002-9343(86)90664-9 Salama, 2008, Massive platelet transfusion is a rapidly effective emergency treatment in patients with refractory autoimmune thrombocytopenia., Thromb Haemost, 100, 762, 10.1160/TH08-06-0418 Spahr, 2008, Treatment of immune-mediated thrombocytopenia purpura with concurrent intravenous immunoglobulin and platelet transfusion: a retrospective review of 40 patients., Am J Hematol, 83, 122, 10.1002/ajh.21060 Danese, 2009, Cost and mortality associated with hospitalizations in patients with immune thrombocytopenic purpura., Am J Hematol, 84, 631, 10.1002/ajh.21500 Neunert, 2011, The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia., Blood, 117, 4190, 10.1182/blood-2010-08-302984 Kumar, Platelet transfusion: a systematic review of the clinical evidence. [published online ahead of print November 12, 2014]., Transfusion American Hospitals Association. Fast facts on US hospitals. Available at: www.aha.org/research/rc/stat-studies/fast-facts.shtml. Accessed December 2014 HCUP Data Use Agreement Training. Available at: www.hcup-us.ahrq.gov/team/NationwideDUA.jsp. Accessed December 2014 Localio, 2001, Adjustments for center in multicenter studies: an overview., Ann Intern Med, 135, 112, 10.7326/0003-4819-135-2-200107170-00012 Hicks, 2014, Association between race and age in survival after trauma., JAMA Surg, 149, 642, 10.1001/jamasurg.2014.166 Software MAD. 3M™ APR DRG software. Available at: http://solutions.3m.com/wps/portal/3M/en_US/Health-Information-Systems/HIS/Products-and-Services/Products-List-A-Z/APR-DRG-Software/ Allford, 2003, Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias., Br J Haematol, 120, 556, 10.1046/j.1365-2141.2003.04049.x Rock, 1998, Laboratory abnormalities in thrombotic thrombocytopenic purpura., Br J Haematol, 103, 1031, 10.1046/j.1365-2141.1998.01080.x Duffy, 2013, Platelet transfusions and bleeding complications associated with plasma exchange catheter placement in patients with presumed thrombotic thrombocytopenic purpura., J Clin Apher, 28, 356 Swisher, 2009, Clinical outcomes after platelet transfusions in patients with thrombotic thrombocytopenic purpura., Transfusion, 49, 873, 10.1111/j.1537-2995.2008.02082.x Linkins, 2012, Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines., Chest, 141, e495S, 10.1378/chest.11-2303 Greinacher, 2005, Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective analysis of 408 patients., Thromb Haemost, 94, 132 Lewis, 2006, Effects of argatroban therapy, demographic variables, and platelet count on thrombotic risks in heparin-induced thrombocytopenia., Chest, 129, 1407, 10.1378/chest.129.6.1407 Hopkins, 2008, Platelet transfusions in heparin-induced thrombocytopenia: a report of four cases and review of the literature., Transfusion, 48, 2128, 10.1111/j.1537-2995.2008.01822.x Refaai, 2010, Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia., J Thromb Haemost, 8, 1419, 10.1111/j.1538-7836.2010.03861.x Tun, 2012, A rare case of intracerebral hemorrhage complicating heparin-induced thrombocytopenia with thrombosis: a clinical dilemma ameliorated by novel use of plasmapheresis., Int J Hematol, 96, 513, 10.1007/s12185-012-1161-3 Cuker, 2012, How I treat heparin-induced thrombocytopenia., Blood, 119, 2209, 10.1182/blood-2011-11-376293 Provan, 2010, International consensus report on the investigation and management of primary immune thrombocytopenia., Blood, 115, 168, 10.1182/blood-2009-06-225565 Blanchette, 2003, Childhood acute immune thrombocytopenic purpura: 20 years later., Semin Thromb Hemost, 29, 605, 10.1055/s-2004-815628 De Mattia, 2010, Management of chronic childhood immune thrombocytopenic purpura: AIEOP consensus guidelines., Acta Haematol, 123, 96, 10.1159/000268855 Rodeghiero, 2009, Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group., Blood, 113, 2386, 10.1182/blood-2008-07-162503 British Committee for Standards in Haematology General Haematology Task Force, 2003, Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy., Br J Haematol, 120, 574, 10.1046/j.1365-2141.2003.04131.x Kawano, 2013, Portal vein thrombosis during eltrombopag treatment for immune thrombocytopenic purpura in a patient with liver cirrhosis due to hepatitis C viral infection., J Clin Exp Hematop, 53, 151, 10.3960/jslrt.53.151 Heckbert, 2004, Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women’s Health Initiative., Am J Epidemiol, 160, 1152, 10.1093/aje/kwh314 Health Cost and Utilization Project Quality Control Procedures Available at: www.ahrq.gov/data/hcup/sasddocu/techsupp2.pdf. Accessed December 2014 Comparative Analysis of HCUP and NHDS Inpatient Discharge Data Available at: www.ahrq.gov/data/hcup/nhds/niscomp.htm George, 2013, The Oklahoma Thrombotic Thrombocytopenic Purpura-haemolytic Uraemic Syndrome Registry. A model for clinical research, education and patient care., Hamostaseologie, 33, 105, 10.5482/HAMO-12-10-0016 Wahl, 2012, Health care utilization of patients diagnosed with idiopathic thrombotic thrombocytopenic purpura in a commercially insured population in the United States., Transfusion, 52, 1614, 10.1111/j.1537-2995.2012.03758.x