Induction of skin sensitization is augmented in Nrf2-deficient mice

Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 87 - Trang 763-766 - 2012
Jochem W. van der Veen1,2, Eric R. Gremmer2, Jolanda P. Vermeulen2, Henk van Loveren1,2, Janine Ezendam2
1Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands
2Laboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

Tóm tắt

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

Tài liệu tham khảo

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