Evolution of Nova-Dependent Splicing Regulation in the Brain

PLoS Genetics - Tập 3 Số 10 - Trang e173
Nejc Jelen1,2,3,4, Jernej Ule2, Marko Živin1, Robert B. Darnell3,4
1Brain Research Laboratory, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia
2Division of Structural Studies, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
3Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

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Tài liệu tham khảo

2002, Alternative pre-mRNA splicing and proteome expansion in metazoans., Nature, 418, 236, 10.1038/418236a

2001, Alternative splicing: increasing diversity in the proteomic world., Trends Genet, 17, 100, 10.1016/S0168-9525(00)02176-4

1994, Split genes and RNA splicing., Cell, 77, 805, 10.1016/0092-8674(94)90130-9

2002, A genomic view of alternative splicing., Nat Genet, 30, 13, 10.1038/ng0102-13

2003, Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays., Science, 302, 2141, 10.1126/science.1090100

2005, Nova regulates brain-specific splicing to shape the synapse., Nat Genet, 37, 844, 10.1038/ng1610

2004, Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data., Nucleic Acids Res, 32, e180, 10.1093/nar/gnh173

2001, The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA., Genes Dev, 15, 2546, 10.1101/gad.903101

1997, A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer., Genes Dev, 11, 1023, 10.1101/gad.11.8.1023

2004, How did alternative splicing evolve?, Nat Rev Genet, 5, 773, 10.1038/nrg1451

2007, The evolutionary significance of cis-regulatory mutations., Nat Rev Genet, 8, 206, 10.1038/nrg2063

2006, Splicing regulation in neurologic disease., Neuron, 52, 93, 10.1016/j.neuron.2006.09.017

SugnetCWKentWJAresMJr.HausslerD 2004 Transcriptome and genome conservation of alternative splicing events in humans and mice. Pac Symp Biocomput 66 77

2003, Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss., Nat Genet, 34, 177, 10.1038/ng1159

2005, Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons., Mol Biol Evol, 22, 2198, 10.1093/molbev/msi218

2005, Protein modularity of alternatively spliced exons is associated with tissue-specific regulation of alternative splicing., PLoS Genet, 1

2006, Unusual intron conservation near tissue-regulated exons found by splicing microarrays., PLoS Comput Biol, 2

1993, Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system., Neuron, 11, 657, 10.1016/0896-6273(93)90077-5

2005, Nova autoregulation reveals dual functions in neuronal splicing., EMBO J, 24, 1608, 10.1038/sj.emboj.7600630

2000, Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability., Neuron, 25, 359, 10.1016/S0896-6273(00)80900-9

2003, Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer., Mol Cell Biol, 23, 4687, 10.1128/MCB.23.13.4687-4700.2003

2003, CLIP identifies Nova-regulated RNA networks in the brain., Science, 302, 1212, 10.1126/science.1090095

1997, The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo., Mol Cell Biol, 17, 3194, 10.1128/MCB.17.6.3194

2006, An RNA map predicting Nova-dependent splicing regulation., Nature, 44, 580

2004, Cell adhesion molecules in synapse formation., J Neurosci, 24, 9244, 10.1523/JNEUROSCI.3339-04.2004

2005, The actin cytoskeleton: integrating form and function at the synapse., Annu Rev Neurosci, 28, 25, 10.1146/annurev.neuro.28.061604.135757

2005, Mechanisms of vertebrate synaptogenesis., Annu Rev Neurosci, 28, 251, 10.1146/annurev.neuro.27.070203.144336

2003, Cell-cell signaling during synapse formation in the CNS., Annu Rev Neurosci, 26, 485, 10.1146/annurev.neuro.26.043002.094940

2003, Mechanisms of alternative pre-messenger RNA splicing., Annu Rev Biochem, 72, 291, 10.1146/annurev.biochem.72.121801.161720

2006, RNA binding proteins and the regulation of neuronal synaptic plasticity., Curr Opin Neurobiol, 16, 102, 10.1016/j.conb.2006.01.003

2007, Exon silencing by UAGG motifs in response to neuronal excitation., PLoS Biol, 5

2007, Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements., PLoS Biol, 5

2003, Conservation of human alternative splice events in mouse., Nucleic Acids Res, 31, 2544, 10.1093/nar/gkg355

2000, Gene structure and promoter function of murine Munc18–2, a nonneuronal exocytic Sec1 homolog., Biochem Biophys Res Commun, 276, 817, 10.1006/bbrc.2000.3513

2000, Synaptic assembly of the brain in the absence of neurotransmitter secretion., Science, 287, 864, 10.1126/science.287.5454.864

2003, Low conservation of alternative splicing patterns in the human and mouse genomes., Hum Mol Genet, 12, 1313, 10.1093/hmg/ddg137

2005, Alternative splicing of conserved exons is frequently species-specific in human and mouse., Trends Genet, 21, 73, 10.1016/j.tig.2004.12.004

2006, Identification and evolutionary analysis of novel exons and alternative splicing events using cross-species EST-to-genome comparisons in human, mouse and rat., BMC Bioinformatics, 7, 136, 10.1186/1471-2105-7-136

2005, Identification and analysis of alternative splicing events conserved in human and mouse., Proc Natl Acad Sci U S A, 102, 2850, 10.1073/pnas.0409742102

2004, Evidence for a subpopulation of conserved alternative splicing events under selection pressure for protein reading frame preservation., Nucleic Acids Res, 32, 1261, 10.1093/nar/gkh284

2004, Variation in sequence and organization of splicing regulatory elements in vertebrate genes., Proc Natl Acad Sci U S A, 101, 15700, 10.1073/pnas.0404901101

2006, Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion., Genome Res, 16, 66, 10.1101/gr.3936206

2003, Transcription regulation and animal diversity., Nature, 424, 147, 10.1038/nature01763

2007, The evolution of gene regulation by transcription factors and microRNAs., Nat Rev Genet, 8, 93, 10.1038/nrg1990

2007, Tissue-specific transcriptional regulation has diverged significantly between human and mouse., Nat Genet, 39, 730, 10.1038/ng2047

2006, The UCSC Genome Browser Database: update 2006., Nucleic Acids Res, 34, D590, 10.1093/nar/gkj144

2004, The UCSC Table Browser data retrieval tool., Nucleic Acids Res, 32, D493, 10.1093/nar/gkh103