The Role of B Vitamins in Preventing and Treating Cognitive Impairment and Decline

Hutto, 1997, Folate and cobalamin in psychiatric illness, Compr Psychiatry, 38, 305, 10.1016/S0010-440X(97)90925-1 McCully, 1975, Homocysteine theory of arteriosclerosis, Atherosclerosis, 22, 215, 10.1016/0021-9150(75)90004-0 Selhub, 1993, Vitamin status and intake as primary determinants of homocysteinemia in an elderly population, JAMA, 270, 2693, 10.1001/jama.1993.03510220049033 Eriksson, 1998, Neurogenesis in the adult human hippocampus, Nat Med, 4, 1313, 10.1038/3305 Driscoll, 2005, The aging hippocampus: navigating between rat and human experiments, Rev Neurosci, 16, 87, 10.1515/REVNEURO.2005.16.2.87 Obeid, 2006, Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia, FEBS Lett, 580, 2994, 10.1016/j.febslet.2006.04.088 Smulders, 2011, The homocysteine controversy, J Inherit Metab Dis, 34, 93, 10.1007/s10545-010-9151-1 Bottiglieri, 2002, S-Adenosyl-L-methionine (SAMe): from the bench to the bedside–molecular basis of a pleiotrophic molecule, Am J Clin Nutr, 76, 1151S, 10.1093/ajcn/76.5.1151S Selhub, 2010, B vitamins and the aging brain, Nutr Rev, 68, S112, 10.1111/j.1753-4887.2010.00346.x Metz, 1992, Cobalamin deficiency and the pathogenesis of nervous system disease, Annu Rev Nutr, 12, 59, 10.1146/annurev.nu.12.070192.000423 Toh, 1997, Pernicious anemia, N Engl J Med, 337, 1441, 10.1056/NEJM199711133372007 De Gennes, 1954, [Addison's disease; acute mental disorders and chronic delirium], Ann Med Psychol (Paris), 112, 522 Carmel, 1988, Pernicious anemia. The expected findings of very low serum cobalamin levels, anemia, and macrocytosis are often lacking, Arch Intern Med, 148, 1712, 10.1001/archinte.1988.00380080016007 Allen, 1998, Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders, Eur J Pediatr, 157, S122, 10.1007/PL00014295 Scott, 1960, Prevalence of pernicious anaemia in Great Britain, J Coll Gen Pract, 3, 80 Pfeiffer, 2005, Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999–2000, Am J Clin Nutr, 82, 442, 10.1093/ajcn/82.2.442 Carmel, 1999, Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities, Am J Clin Nutr, 70, 904, 10.1093/ajcn/70.5.904 Lindenbaum, 1994, Prevalence of cobalamin deficiency in the Framingham elderly population, Am J Clin Nutr, 60, 2, 10.1093/ajcn/60.1.2 Morris, 2002, Elevated serum methylmalonic acid concentrations are common among elderly Americans, J Nutr, 132, 2799, 10.1093/jn/132.9.2799 Björkegren, 2001, Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes–a population-based study, J Intern Med, 249, 423, 10.1046/j.1365-2796.2001.00819.x Carmel, 2008, Mean corpuscular volume and other concerns in the study of vitamin B-12 deficiency: epidemiology with pathophysiology, Am J Clin Nutr, 87, 1962, 10.1093/ajcn/87.6.1962 Andrès, 2003, The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients, Eur J Intern Med, 14, 221, 10.1016/S0953-6205(03)00074-8 Carmel, 2012, Subclinical cobalamin deficiency, Curr Opin Gastroenterol, 28, 151, 10.1097/MOG.0b013e3283505852 Snowdon, 1997, Brain infarction and the clinical expression of Alzheimer disease. The Nun Study, JAMA, 277, 813, 10.1001/jama.1997.03540340047031 Larkin, 1998, Kilmer McCully: pioneer of the homocysteine theory, Lancet, 352 Bell, 1992, Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people, Acta Psychiatr Scand, 86, 386, 10.1111/j.1600-0447.1992.tb03285.x Riggs, 1996, Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study, Am J Clin Nutr, 63, 306, 10.1093/ajcn/63.3.306 Clarke, 1998, Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease, Arch Neurol, 55, 1449, 10.1001/archneur.55.11.1449 Ellinson, 2004, A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly, J Hum Nutr Diet, 17, 371, 10.1111/j.1365-277X.2004.00532.x Raman, 2007, Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function, J Nutr, 137, 1789, 10.1093/jn/137.7.1789 Smith, 2008, The worldwide challenge of the dementias: a role for B vitamins and homocysteine?, Food Nutr Bull, 29, S143, 10.1177/15648265080292S119 Ford, 2012, Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials, J Alzheimers Dis, 29, 133, 10.3233/JAD-2012-111739 Balk, 2007, Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials, Arch Intern Med, 167, 21, 10.1001/archinte.167.1.21 Wald, 2010, Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials, Am J Med, 123, 522, 10.1016/j.amjmed.2010.01.017 Malouf, 2008, Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people, Cochrane Database Syst Rev Vogel, 2009, Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature, Int J Clin Pract, 63, 1061, 10.1111/j.1742-1241.2009.02026.x de Jager, 2010, Summary and discussion: Methodologies to assess long-term effects of nutrition on brain function, Nutr Rev, 68, S53, 10.1111/j.1753-4887.2010.00332.x Kim, 2008, Changes in folate, vitamin B12 and homocysteine associated with incident dementia, J Neurol Neurosurg Psychiatry, 79, 864, 10.1136/jnnp.2007.131482 Luchsinger, 2004, Plasma homocysteine levels and risk of Alzheimer disease, Neurology, 62, 1972, 10.1212/01.WNL.0000129504.60409.88 McIlroy, 2002, Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland, Stroke, 33, 2351, 10.1161/01.STR.0000032550.90046.38 Kivipelto, 2009, Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study, Eur J Neurol, 16, 808, 10.1111/j.1468-1331.2009.02590.x Quadri, 2004, Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia, Am J Clin Nutr, 80, 114 Seshadri, 2002, Plasma homocysteine as a risk factor for dementia and Alzheimer's disease, N Engl J Med, 346, 476, 10.1056/NEJMoa011613 Ramos, 2005, Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging, Am J Clin Nutr, 82, 1346, 10.1093/ajcn/82.6.1346 Ravaglia, 2005, Homocysteine and folate as risk factors for dementia and Alzheimer disease, Am J Clin Nutr, 82, 636, 10.1093/ajcn/82.3.636 Redéen, 2010, Homocysteine levels in chronic gastritis and other conditions: relations to incident cardiovascular disease and dementia, Dig Dis Sci, 55, 351, 10.1007/s10620-009-0761-0 Zylberstein, 2011, Midlife homocysteine and late-life dementia in women. A prospective population study, Neurobiol Aging, 32, 380, 10.1016/j.neurobiolaging.2009.02.024 Hooshmand, 2010, Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study, Neurology, 75, 1408, 10.1212/WNL.0b013e3181f88162 Mazza, 2005, Reduced serum homocysteine levels in type 2 diabetes, Nutr Metab Cardiovasc Dis, 15, 118, 10.1016/j.numecd.2004.03.001 Mazza, 2000, Glycemia, MTHFR genotype and low homocysteine in uncomplicated type 2 diabetic patients, Atherosclerosis, 149, 223 Herrmann, 2003, Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk, Clin Chem Lab Med, 41, 1478, 10.1515/CCLM.2003.227 Luchsinger, 2007, Relation of higher folate intake to lower risk of Alzheimer disease in the elderly, Arch Neurol, 64, 86, 10.1001/archneur.64.1.86 Wang, 2001, Vitamin B(12) and folate in relation to the development of Alzheimer's disease, Neurology, 56, 1188, 10.1212/WNL.56.9.1188 Corrada, 2005, Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging, Alzheimer Dement, 1, 11, 10.1016/j.jalz.2005.06.001 Morris, 2006, Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease, J Alzheimers Dis, 9, 435, 10.3233/JAD-2006-9410 Shane, 2011, Folate status assessment history: implications for measurement of biomarkers in NHANES, Am J Clin Nutr, 94, 337S, 10.3945/ajcn.111.013367 Diniz, 2007, Mini-mental State Examination performance in mild cognitive impairment subtypes, Int Psychogeriatr, 19, 647, 10.1017/S104161020700542X Kalmijn, 1999, Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study, Am J Epidemiol, 150, 283, 10.1093/oxfordjournals.aje.a010000 Budge, 2002, Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people, J Am Geriatr Soc, 50, 2014, 10.1046/j.1532-5415.2002.50614.x Duthie, 2002, Homocysteine, B vitamin status, and cognitive function in the elderly, Am J Clin Nutr, 75, 908, 10.1093/ajcn/75.5.908 Robbins, 2005, Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Maine-Syracuse Study, Clin Chem Lab Med, 43, 1101, 10.1515/CCLM.2005.192 Dufouil, 2003, Homocysteine, white matter hyperintensities, and cognition in healthy elderly people, Ann Neurol, 53, 214, 10.1002/ana.10440 Feng, 2006, Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study, Am J Clin Nutr, 84, 1506, 10.1093/ajcn/84.6.1506 Ravaglia, 2003, Homocysteine and cognitive function in healthy elderly community dwellers in Italy, Am J Clin Nutr, 77, 668, 10.1093/ajcn/77.3.668 Wright, 2004, Total homocysteine and cognition in a tri-ethnic cohort: the Northern Manhattan Study, Neurology, 63, 254, 10.1212/01.WNL.0000129986.19019.5D Hin, 2006, Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study, Age Ageing, 35, 416, 10.1093/ageing/afl033 Hooshmand, 2012, Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study, J Intern Med, 271, 204, 10.1111/j.1365-2796.2011.02484.x Tucker, 2005, High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study, Am J Clin Nutr, 82, 627, 10.1093/ajcn/82.3.627 Clarke, 2007, Low vitamin B-12 status and risk of cognitive decline in older adults, Am J Clin Nutr, 86, 1384, 10.1093/ajcn/86.5.1384 Mooijaart, 2005, Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study, Am J Clin Nutr, 82, 866, 10.1093/ajcn/82.4.866 De Jager, 2003, Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease, Psychol Med, 33, 1039, 10.1017/S0033291703008031 Narayan, 2011, Plasma homocysteine and cognitive decline in older hypertensive subjects, Int Psychogeriatr, 23, 1607, 10.1017/S1041610211000779 Gallagher, 2010, Detecting prodromal Alzheimer's disease in mild cognitive impairment: utility of the CAMCOG and other neuropsychological predictors, Int J Geriatr Psychiatry, 25, 1280, 10.1002/gps.2480 Morris, 2001, Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey, Am J Clin Nutr, 73, 927, 10.1093/ajcn/73.5.927 Prins, 2002, Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study, Neurology, 59, 1375, 10.1212/01.WNL.0000032494.05619.93 Elias, 2005, Homocysteine and cognitive performance in the Framingham offspring study: age is important, Am J Epidemiol, 162, 644, 10.1093/aje/kwi259 Clark, 2005, Hyperhomocysteinemia is associated with lower performance on memory tasks in post-menopausal women, Dement Geriatr Cogn Disord, 20, 57, 10.1159/000085856 Schafer, 2005, Homocysteine and cognitive function in a population-based study of older adults, J Am Geriatr Soc, 53, 381, 10.1111/j.1532-5415.2005.53153.x Nurk, 2005, Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study, Ann Neurol, 58, 847, 10.1002/ana.20645 Elias, 2006, Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study, Psychosom Med, 68, 547, 10.1097/01.psy.0000221380.92521.51 Miller, 2003, Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging, Am J Clin Nutr, 78, 441, 10.1093/ajcn/78.3.441 de Lau, 2007, Plasma folate concentration and cognitive performance: Rotterdam Scan Study, Am J Clin Nutr, 86, 728, 10.1093/ajcn/86.3.728 Green, 2005, Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population, Clin Chem Lab Med, 43, 1048, 10.1515/CCLM.2005.183 Joy, 2004, Speed and memory in the WAIS-III Digit Symbol–Coding subtest across the adult lifespan, Arch Clin Neuropsychol, 19, 759, 10.1016/j.acn.2003.09.009 Morris, 2007, Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification, Am J Clin Nutr, 85, 193, 10.1093/ajcn/85.1.193 Strauss, 2006 Wallesch, 2001, The neuropsychology of blunt head injury in the early postacute stage: effects of focal lesions and diffuse axonal injury, J Neurotrauma, 18, 11, 10.1089/089771501750055730 Sweeney, 2007, Scientific investigation of brain-behavior relationships using the Halstead-Reitan Battery, Appl Neuropsychol, 14, 65, 10.1080/09084280701319763 Almkvist, 2003, Cognitive syndrome(s) in preclinical and clinical vascular dementia, Int Psychogeriatr, 15, 127, 10.1017/S1041610203009086 Graham, 2004, Distinctive cognitive profiles in Alzheimer's disease and subcortical vascular dementia, J Neurol Neurosurg Psychiatry, 75, 61 Au, 2006, Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study, Arch Neurol, 63, 246, 10.1001/archneur.63.2.246 Kado, 2005, Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging, Am J Med, 118, 161, 10.1016/j.amjmed.2004.08.019 van den Kommer, 2010, Homocysteine and inflammation: predictors of cognitive decline in older persons?, Neurobiol Aging, 31, 1700, 10.1016/j.neurobiolaging.2008.09.009 Garcia, 2004, Homocysteine and cognitive function in elderly people, CMAJ, 171, 897, 10.1503/cmaj.1031586 Tangney, 2009, Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline, Neurology, 72, 361, 10.1212/01.wnl.0000341272.48617.b0 Ravaglia, 2000, Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects, J Nutr Health Aging, 4, 218 Bernard, 1998, The effect of vitamin B12 deficiency on older veterans and its relationship to health, J Am Geriatr Soc, 46, 1199, 10.1111/j.1532-5415.1998.tb04534.x Lindeman, 2000, Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: correlations with cognitive and affective functions, J Am Coll Nutr, 19, 68, 10.1080/07315724.2000.10718916 Morris MS, Selhub J, Jacques PF, Vitamin B-12 and folate status in relation to decline in scores on the Mini-Mental State Examination in the Framingham Heart Study. J Am Geriatr Soc. Epub 2012Jul 12. Durga, 2006, Folate and the methylenetetrahydrofolate reductase 677C→T mutation correlate with cognitive performance, Neurobiol Aging, 27, 334, 10.1016/j.neurobiolaging.2005.01.003 Kang, 2006, Prospective study of plasma folate, vitamin B12, and cognitive function and decline, Epidemiology, 17, 650, 10.1097/01.ede.0000239727.59575.da Jelicic, 2001, Effect of low levels of serum vitamin B12 and folic acid on cognitive performance in old age: a population-based study, Dev Neuropsychol, 20, 565, 10.1207/S15326942DN2003_1 Tangney, 2011, Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination, Neurology, 77, 1276, 10.1212/WNL.0b013e3182315a33 Garcia, 2004, Metabolic markers of cobalamin deficiency and cognitive function in normal older adults, J Am Geriatr Soc, 52, 66, 10.1111/j.1532-5415.2004.52012.x Morris, 2005, Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons, Arch Neurol, 62, 641, 10.1001/archneur.62.4.641 Reynolds, 1995, Folic acid and the prevention of neural tube defects. Folate has potential to cause harm, BMJ, 311, 257, 10.1136/bmj.311.6999.257 Palca, 1992, Folic acid. Agencies split on nutrition advice, Science, 257, 10.1126/science.1301026 Reynolds, 2006, Vitamin B12, folic acid, and the nervous system, Lancet Neurol, 5, 949, 10.1016/S1474-4422(06)70598-1 Morris, 2010, Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors, Am J Clin Nutr, 91, 1733, 10.3945/ajcn.2009.28671 Clarke, 2008, Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK, Br J Nutr, 100, 1054, 10.1017/S0007114508958001 Fioravanti, 1998, Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits, Arch Gerontol Geriatr, 26, 1, 10.1016/S0167-4943(97)00028-9 McMahon, 2006, A controlled trial of homocysteine lowering and cognitive performance, N Engl J Med, 354, 2764, 10.1056/NEJMoa054025 Durga, 2007, Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial, Lancet, 369, 208, 10.1016/S0140-6736(07)60109-3 Walker, 2012, Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms–the Beyond Ageing Project: a randomized controlled trial, Am J Clin Nutr, 95, 194, 10.3945/ajcn.110.007799 Kelly, 1997, Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements, Am J Clin Nutr, 65, 1790, 10.1093/ajcn/65.6.1790 Food and Nutrition Board IoM, 2000 Eussen, 2005, Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial, Arch Intern Med, 165, 1167, 10.1001/archinte.165.10.1167 Rajan, 2002, Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults, J Am Geriatr Soc, 50, 1789, 10.1046/j.1532-5415.2002.50506.x Pfeiffer, 2012, Assessing vitamin status in large population surveys by measuring biomarkers and dietary intake--two case studies: folate and vitamin D, Food Nutr Res, 56, 10.3402/fnr.v56i0.5944 Kang, 2008, A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease, Am J Clin Nutr, 88, 1602, 10.3945/ajcn.2008.26404