FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

American Association for the Advancement of Science (AAAS) - Tập 268 Số 5209 - Trang 411-415 - 1995
Takaaki Sato1, Shinji Irie1, Shinichi Kitada1, John C. Reed1
1La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, La Jolla, CA 92037, USA.

Tóm tắt

Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable of interacting with the cytosolic domain of Fas, was identified. The carboxyl terminal 15 amino acids of Fas are necessary and sufficient for interaction with FAP-1. FAP-1 expression is highest in tissues and cell lines that are relatively resistant to Fas-mediated cytotoxicity. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line. These findings are consistent with an inhibitory effect of FAP-1 on Fas signal transduction.

Từ khóa


Tài liệu tham khảo

ALDERSON, M.R., FAS TRANSDUCES ACTIVATION SIGNALS IN NORMAL HUMAN T-LYMPHOCYTES, JOURNAL OF EXPERIMENTAL MEDICINE 178: 2231 (1993).

10.1126/science.7510905

EISCHEN, C.M., TYROSINE KINASE ACTIVATION PROVIDES AN EARLY AND REQUISITE SIGNAL FOR FAS-INDUCED APOPTOSIS, JOURNAL OF IMMUNOLOGY 153: 1947 (1994).

GORCZYCA, W, DETECTION OF DNA STRAND BREAKS IN INDIVIDUAL APOPTOTIC CELLS BY THE INSITU TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE AND NICK TRANSLATION ASSAYS, CANCER RESEARCH 53: 1945 (1993).

ITOH, N, THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS, CELL 66: 233 (1991).

ITOH, N, A NOVEL PROTEIN DOMAIN REQUIRED FOR APOPTOSIS - MUTATIONAL ANALYSIS OF HUMAN FAS ANTIGEN, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 10932 (1993).

ITOH, N, EFFECT OF BCL-2 ON FAS ANTIGEN-MEDIATED CELL-DEATH, JOURNAL OF IMMUNOLOGY 151: 621 (1993).

KLAS, C, ACTIVATION INTERFERES WITH THE APO-1 PATHWAY IN MATURE HUMAN T-CELLS, INTERNATIONAL IMMUNOLOGY 5: 625 (1993).

LYNCH, D.H., THE MOUSE FAS-LIGAND GENE IS MUTATED IN GLD MICE AND IS PART OF A TNF FAMILY GENE-CLUSTER, IMMUNITY 1: 131 (1994).

MAEKAWA, K, MOLECULAR-CLONING OF A NOVEL PROTEIN-TYROSINE-PHOSPHATASE CONTAINING A MEMBRANE-BINDING DOMAIN AND GLGF REPEATS, FEBS LETTERS 337: 200 (1994).

MAPARA, M.Y., APO-1 MEDIATED APOPTOSIS OR PROLIFERATION IN HUMAN CHRONIC B-LYMPHOCYTIC LEUKEMIA - CORRELATION WITH BCL-2 ONCOGENE EXPRESSION, EUROPEAN JOURNAL OF IMMUNOLOGY 23: 702 (1993).

MOLLER, NPH, SRC KINASE ASSOCIATES WITH A MEMBER OF A DISTINCT SUBFAMILY OF PROTEIN-TYROSINE PHOSPHATASES CONTAINING AN EZRIN-LIKE DOMAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 7477 (1994).

OWENSCHAUB, L.B., ANTI-FAS ON NONHEMATOPOIETIC TUMORS - LEVELS OF FAS/APO-1 AND BCL-2 ARE NOT PREDICTIVE OF BIOLOGICAL RESPONSIVENESS, CANCER RESEARCH 54: 1580 (1994).

SATO, T, INTERACTIONS AMONG MEMBERS OF THE BCL-2 PROTEIN FAMILY ANALYZED WITH A YEAST 2-HYBRID SYSTEM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 9238 (1994).

SATO T unpublished data.

SMITH, C.A., THE TNF RECEPTOR SUPERFAMILY OF CELLULAR AND VIRAL-PROTEINS - ACTIVATION, COSTIMULATION, AND DEATH, CELL 76: 959 (1994).

SUDA, T, MOLECULAR-CLONING AND EXPRESSION OF THE FAS LIGAND, A NOVEL MEMBER OF THE TUMOR-NECROSIS-FACTOR FAMILY, CELL 75: 1169 (1993).

TAKAHASHI, S, ESTABLISHMENT OF APOPTOSIS-INDUCING MONOCLONAL-ANTIBODY 2D1 AND 2D1-RESISTANT VARIANTS OF HUMAN T-CELL LINES, EUROPEAN JOURNAL OF IMMUNOLOGY 23: 1935 (1993).

TAKAHASHI, T, GENERALIZED LYMPHOPROLIFERATIVE DISEASE IN MICE, CAUSED BY A POINT MUTATION IN THE FAS LIGAND, CELL 76: 969 (1994).

10.1016/0092-8674(95)90410-7

10.1126/science.2787530

10.1016/0092-8674(93)90307-C

WATANABEFUKUNAG.R, LYMPHOPROLIFERATION DISORDER IN MICE EXPLAINED BY DEFECTS IN FAS ANTIGEN THAT MEDIATES APOPTOSIS, NATURE 356: 314 (1992).

YONEHARA, S, A CELL-KILLING MONOCLONAL-ANTIBODY (ANTI-FAS) TO A CELL-SURFACE ANTIGEN CO-DOWNREGULATED WITH THE RECEPTOR OF TUMOR NECROSIS FACTOR, JOURNAL OF EXPERIMENTAL MEDICINE 169: 1747 (1989).

ZERVOS, A.S., MXI1, A PROTEIN THAT SPECIFICALLY INTERACTS WITH MAX TO BIND MYC-MAX RECOGNITION SITES, CELL 72: 223 (1993).