Plasma levels after peroral and topical ibuprofen and effects upon low pH‐induced cutaneous and muscle pain
Tóm tắt
Cutaneous applications are gaining popularity in the treatment of cutaneous pain and of painful disorders in joints and muscle. The low pH‐pain model in human skin has previously been able to demonstrate the effects of NSAIDs in dose‐dependent manner and to establish time‐effect relationships. We examined the analgesic action of ibuprofen after cutaneous application and compared the effects with oral administration. The two studies (with
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Tài liệu tham khảo
Baillie T.A., 1989, Mechanistic studies of the metabolic chiral inversion of R‐ibuprofen in humans, J Pharmacol Exp Ther, 249, 517
Berner G., 1989, Percutaneous ibuprofen therapy with Trauma‐Dolgit gel: bioequivalence studies, Drugs Exp Clin Res, 15, 559
Dominkus M., 1996, Comparison of tissue and plasma levels of ibuprofen after oral and topical administration, Arzneimittelforschung, 46, 1138
Giese U., 1990, Absorption and distribution of ibuprofen from a cream formulation after dermal administration to guinea pigs, Arzneimittelforschung, 40, 84
Günther S., 1999, Rises in [Ca2+]imediate capsaicin‐ and proton‐induced heat sensitization of rat primary nociceptive neurons, Eur J Neurosci, 11, 3141
Longhurst J.C., 1991, Ischemically sensitive abdominal visceral afferents: response to cyclooxygenase blockade, Am J Physiol, 261, H2075
Steen A.E., 1998, Effects of peroral and topical ibuprofen upon low pH‐induced cutaneous and muscle pain, Pflügers Arch, 435, R152
Steen A. E., 1996, Topical acetylsalicylic acid applied to the skin of herpes zoster‐patients strongly reduces their acute neuralgia, R276
Steen K.H., 1998, Sustained acidosis induces sensitization to heat stimulation of rat cutaneous nociceptors, in vitro. Pflügers Arch, 435, R152
Wegner H., 2000, Neurosci Lett